Dihydrocaffeic acid
- Product Name
- Dihydrocaffeic acid
- CAS No.
- 1078-61-1
- Chemical Name
- Dihydrocaffeic acid
- Synonyms
- NSC 407275;NSC 624007;Hydrocaffeate;HYDROCAFFEIC ACID;3-propionic acid;DIHYDROCAFFEIC ACID;DIHYDROCAFFEIC ACID(RG);3,4-DIHYDROCAFFEIC ACID;13C6]-Dihydrocaffeic acid;4-Dihydroxyhydrocinnamic acid
- CBNumber
- CB1439090
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 1078-61-1.mol
Dihydrocaffeic acid Property
- Melting point:
- 136-139 °C(lit.)
- Boiling point:
- 418℃
- Density
- 1.398
- Flash point:
- 220℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.75±0.10(Predicted)
- color
- Pale Beige to Pale Brown
- Water Solubility
- Slightly soluble in water.
- BRN
- 2213449
- InChI
- InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
- InChIKey
- DZAUWHJDUNRCTF-UHFFFAOYSA-N
- SMILES
- C1(CCC(O)=O)=CC=C(O)C(O)=C1
- LogP
- 0.115 (est)
- CAS DataBase Reference
- 1078-61-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 102601
- Product name
- 3,4-Dihydroxyhydrocinnamic acid
- Purity
- 98%
- Packaging
- 25G
- Price
- $95.7
- Updated
- 2025/07/31
- Product number
- 102601
- Product name
- 3,4-Dihydroxyhydrocinnamic acid
- Purity
- 98%
- Packaging
- 10G
- Price
- $245
- Updated
- 2025/07/31
- Product number
- 102601
- Product name
- 3,4-Dihydroxyhydrocinnamic acid
- Purity
- 98%
- Packaging
- 2.5G
- Price
- $479
- Updated
- 2025/07/31
- Product number
- D5901
- Product name
- 3,4-Dihydroxyhydrocinnamic Acid
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $92
- Updated
- 2025/07/31
- Product number
- D5901
- Product name
- 3,4-Dihydroxyhydrocinnamic Acid
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $275
- Updated
- 2025/07/31
Dihydrocaffeic acid Chemical Properties,Usage,Production
Description
Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties. Dihydrocaffeic acid scavenges ABTS (; IC50 = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; ; IC50 = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; ) in a concentration-dependent manner. It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner. In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).
Chemical Properties
Brown Solid
Uses
3-(3,4-Dihydroxyphenyl)propionic acid it can be used to produce 3-(3,4-dihydroxy-phenyl)-propionic acid octyl ester by heating.
Uses
Dihydrocaffeic Acid is a natural product containing a catechol group with an α,β-unsaturated carboxylic acid chain. Dihydrocaffeic Acid has been shown to have hepatoprotective activity. Dihydrocaffei c Acid is a metabolite of Caffeic Acid (C08000) with potent antioxidant properties.
Definition
ChEBI: A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. It is a metabolite of caffeic acid and exhibits antioxidant activity.
in vivo
Dihydrocaffeic acid (3-30 mg/kg, i.p.) protects against ischemia-induced neuronal damage and cerebral edema in a rat model of focal cerebral ischemia[8].
IC 50
Microbial Metabolite; p38 MAPK; Human Endogenous Metabolite
References
[1] HOLIM JANG. Effects of phenolic acid metabolites formed after chlorogenic acid consumption on retinal degeneration in vivo[J]. Molecular Nutrition & Food Research, 2015, 59 10: 1918-1929. DOI: 10.1002/mnfr.201400897
[2] KYUNGJIN LEE Youngmin B Beom Joon Lee. Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model.[J]. Molecules, 2015, 20 7: 11930-11940. DOI: 10.3390/molecules200711930
[3] JUNJUN HUANG James M M Tomas de Paulis. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells[J]. Journal of Nutritional Biochemistry, 2004, 15 12: Pages 722-729. DOI: 10.1016/j.jnutbio.2004.07.002
Dihydrocaffeic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Dihydrocaffeic acid Suppliers
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View Lastest Price from Dihydrocaffeic acid manufacturers
- Product
- 3-(3,4-DIHYDROXYPHENYL)PROPIONIC ACID 1078-61-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-04
- Product
- Dihydrocaffeic acid 1078-61-1
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-04-24
- Product
- Dihydrocaffeic acid 1078-61-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28