Fmoc-Lys(Boc)-OH

ChemicalBook > CAS DataBase List > Fmoc-Lys(Boc)-OH

Product Name: Fmoc-Lys(Boc)-OH
CAS No.: 71989-26-9
Chemical Name: Fmoc-Lys(Boc)-OH
Synonyms: FMOC-LYS(BOC)-OH;FMOC-LYS(BOC);FMOC-L-LYS(BOC)-OH;FMOC-D-LYS(BOC);fmoc-lys(boc)-o;FMOC-L-LYS(BOC);Fmoc-L-Lysine(Boc)-OH;Nα-Fmoc-Nε-Boc-L-lysine;Nα-Fmoc-Nε-Boc-L-lysine;N6-(TERT-BUTOXYCARBONYL)-N2-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LYSINE
CBNumber: CB1451227
Molecular Formula: C26H32N2O6
Formula Weight: 468.54
MOL File: 71989-26-9.mol

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Fmoc-Lys(Boc)-OH Property

Melting point:: 130-135 °C (dec.)
alpha: -12 º (c=2,DMF 24 ºC)
Boiling point:: 570.69°C (rough estimate)
Density: 1.2301 (rough estimate)
refractive index: -12 ° (C=1, DMF)
storage temp.: Store below +30°C.
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 3.88±0.21(Predicted)
form: Powder
color: White
optical activity: [α]20/D 12±1°, c = 1% in DMF
Water Solubility: Slightly soluble in water.
BRN: 4217767
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: UMRUUWFGLGNQLI-QFIPXVFZSA-N
CAS DataBase Reference: 71989-26-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25-36/37/39-27-26
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52012
Product name: Fmoc-Lys(Boc)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $72.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52012
Product name: Fmoc-Lys(Boc)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $183
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52012
Product name: Fmoc-Lys(Boc)-OH
Purity: Novabiochem?
Packaging: 250g
Price: $365
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52012
Product name: Fmoc-Lys(Boc)-OH
Purity: Novabiochem?
Packaging: 1kg
Price: $1370
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47624
Product name: Fmoc-Lys(Boc)-OH
Purity: ≥98.0% (HPLC)
Packaging: 1G
Price: $28.5
Updated: 2024/03/01

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Fmoc-Lys(Boc)-OH Chemical Properties,Usage,Production

Description

Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2].

Chemical Properties

white to light yellow crystal powde

Uses

It is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use.

Uses

Fmoc-Lys(Boc)-OH can be used for:

The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as ¹⁹F NMR based screening tool.

References

[1] Gour N, et al. Controlled aggregation properties of modified single amino acids. ChemRxiv, 2021; 46.
[2] Zhong X, et al. Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics. Molecular Pharmaceutics, 2023; 20: 2402–2414.

Fmoc-Lys(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-Lys(Boc)-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-alpha-FMOC-Nepsilon-BOC-L-Lysine 71989-26-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99.5%min
Supply Ability: 500KGS
Release date: 2021-06-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Lys(Boc)-OH 71989-26-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-29

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Fmoc-Lys(Boc)-OH 71989-26-9
Price: US $0.00/gram
Min. Order: 25gram
Purity: 99% min
Supply Ability: 20 tons
Release date: 2023-10-16

71989-26-9, Fmoc-Lys(Boc)-OHRelated Search:

Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate N-(9-Fluorenylmethoxycarbonyloxy)succinimide L-Lysine AC-HIS-OH H2O Cbz-beta-Amino-L-alanine DI-TERT-BUTYL ETHER FMOC-Ala-OH FMOC-S-trityl-L-cysteine Fmoc-Asp(OtBu)-OH FMOC-L-Valine FMOC-L-Methionine FMOC-N-METHYL-TRANEXAMIC ACID Fmoc-L-Tyr(propargyl)-OH Fmoc-Gly-OH FMOC-O-tert-Butyl-L-serine Fmoc-Asn(Trt)-OH FMOC-TRANEXAMIC ACID

Nα-FMoc-Nε-Boc-L-lysine

(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-6-((tert-butoxycarbonyl)aMino)hexanoic acid

N^e-Boc-N^a-FMoc-L-lysine, 98%

ALPHA-FMOC-EPSILON-BOC-LYSINE

fmoc-lys(boc)-o

Nα-Fmoc-Nε-Boc-L-lysine

L-LYSINE, N6-[(1,1-DIMETHYLETHOXY)CARBONYL]-N2-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-

FMOC-D-LYS(BOC)

FMOC-D-LYSINE(BOC)-OH

FMOC-L-LYS(TBOC)-OH

FMOC-L-LYS(BOC)

FMOC-L-LYS(BOC)-OH

FMOC-L-LYSINE(BOC)

FMOC-L-LYSINE (TBOC)

FMOC-N-EPSILON-BOC-D-LYSINE

FMOC-N-EPSILON-BOC-L-LYSINE

FMOC-LYS(BOC)-OH

FMOC-LYS(BOC)

FMOC-LYSINE(BOC)-OH

Nα-Fmoc-Nε-Boc-L-lysine

Fmoc-(Boc)lysine

Fmoc-Lys(Boc)-OH (N-Alpha-Fmoc-N-Epsilon-Boc-L-Lysine)

N-alpha-FMOC-Nepsilo

Nalpha-FMOC-Nepsilon-BOC-L-Lysine,99%

L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC

Nepsilon-Boc-Nalpha-Fmoc-L-lysine Fmoc-Lys(Boc)-OH

Fmoc-Iys(Boc)-OH

(9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(Boc)-OH

Fomc-Lys(B

ys(Boc)-OH

FMoc-Lys(Boc)-OH >=98.0% (HPLC)

Fmoc-Lys(Boc)-OH(CAS:71989-26-9)

L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (13C6

L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (1-13C)

Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid

Nα-Fmoc-Nε-Boc-L-lysine≥ 99.5% (HPLC, Chiral purity)

N-α-FMOC-N-&epsi:-BOC-L-lysine

N-ALPHA-FMOC-N-EPSILON-BOC-D-LYSINE

N-ALPHA-FMOC-N-EPSILON-BOC-L-LYSINE

N-ALPHA-FMOC-N-EPSILON-T-BOC-D-LYSINE

N-ALPHA-FMOC-N-EPSILON-T-BOC-L-LYSINE

N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-D-LYSINE

N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE

N-ALPHA-FMOC-N-EPSILON-TERT-BOC-D-LYSINE

N-ALPHA-FMOC-N-EPSILON-TERT-BOC-L-LYSINE

N-ALPHA-FMOC-T-BOC-L-LYS

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE

NEPSILON-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L- lysine

FMOC-N-(EPSILON)-BOC-L-LYSINE (FMOC-L-LYS(BOC)-OH)

FMOC-N-E-BOC-L-LYSINE

N-α-Fmoc-N-ε-t.-Boc-L-lysine

L-Lysine-UL-13C6, 15N2-α-N-FMOC, ε-N-t-BOC

L-Lysine-1-13C-α-N-FMOC, ε-N-t-BOC

N6-(TERT-BUTOXYCARBONYL)-N2-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LYSINE

NA-FMOC-N-E-BOC-L-LYSINE

N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE