Ethyl 3-(benzylamino)propanoate

Product Name: Ethyl 3-(benzylamino)propanoate
CAS No.: 23583-21-3
Chemical Name: Ethyl 3-(benzylamino)propanoate
Synonyms: bzl-á-ala-oet;Bzl-beta-Ala-OEt;ethyl N-benzyl-beta-alaninate;N-Benzyl-b-alanine ethyl ester;n-benzyl-á-alanine ethyl ester;N-Benzyl-β-alanine Ethyl Ester;ETHYL 3-(BENZYLAMINO)PROPIONATE;ETHYL 3-(BENZYLAMINO)PROPANOATE;N-BENZYL-SS-ALANINE ETHYL ESTER;Ethyl 4-(benzylamino)propanoate
CBNumber: CB1468315
Molecular Formula: C12H17NO2
Formula Weight: 207.27
MOL File: 23583-21-3.mol

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Ethyl 3-(benzylamino)propanoate Property

Boiling point:: 150 °C
Density: 1.017 g/mL at 25 °C
refractive index: 1.503
Flash point:: 150°C/0.2mm
storage temp.: -20°C
pka: 8.57±0.19(Predicted)
form: clear liquid
color: Colorless to Almost colorless
InChI: InChI=1S/C12H17NO2/c1-2-15-12(14)8-9-13-10-11-6-4-3-5-7-11/h3-7,13H,2,8-10H2,1H3
InChIKey: HCTJHQFFNDLDPF-UHFFFAOYSA-N
SMILES: C(C1C=CC=CC=1)NCCC(=O)OCC
CAS DataBase Reference: 23583-21-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/38-52/53-22
Safety Statements: 26-36/37/39-61
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 700959
Product name: Ethyl 3-(benzylamino)propionate
Purity: 97%
Packaging: 25g
Price: $76
Updated: 2023/06/20

Sigma-Aldrich

Product number: 700959
Product name: Ethyl 3-(benzylamino)propionate
Purity: 97%
Packaging: 5g
Price: $35.8
Updated: 2023/01/07

TCI Chemical

Product number: B1579
Product name: Ethyl 3-(Benzylamino)propionate
Purity: >95.0%(GC)
Packaging: 25mL
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B1579
Product name: Ethyl 3-(Benzylamino)propionate
Purity: >95.0%(GC)
Packaging: 500mL
Price: $467
Updated: 2025/07/31

TRC

Product number: B232975
Product name: N-Benzyl-β-alanineEthylEster
Packaging: 50g
Price: $250
Updated: 2021/12/16

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Ethyl 3-(benzylamino)propanoate Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

N-Benzyl-β-alanine Ethyl Ester is used as a reagent in organic synthesis including that of dipivaloyloxyphenyl aminopropionate β-agonist prodrugs which are used in the treatment of psoriasis. It is also used in the synthesis of N,N''-dithiobis(N-benzyl-β-alanine) dethyl ester, which is an important intermediate of insecticide OK-135, and in synthesis of spiropiperidine-based orexin-2 receptor (OX2R) antagonists.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

100-46-9

140-88-5

23583-21-3

6938-07-4

GENERAL METHODS: Benzylamine (7.5 mmol) was mixed with ethyl acrylate (5 mmol) in a molar ratio of 1.5:1 under acidic alumina (1 g, 200 mol%) as a catalyst and the reaction was carried out by refluxing under stirring. The reaction was heated by oil bath and the progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) until completion. After completion of the reaction, it was cooled to room temperature and the catalyst was removed by filtration through filter paper. The catalyst was rinsed with a solvent mixture of ethyl acetate/hexane and the filtrate was subsequently concentrated by rotary evaporation. The crude product was purified by silica gel column chromatography, using hexane/ethyl acetate as eluent of choice. For aliphatic amine derivatives, a hexane/ethyl acetate ratio of 7:3, 6:4, or 5:5 was typically used to elute the monoadducts, while for aromatic compounds, a hexane/ethyl acetate ratio of 8:2 was used. The yields of the purified products were recorded and infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) analyses were performed to confirm the product structures.

References

[1] Molecules, 2016, vol. 21, # 6,
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 971
[3] New Journal of Chemistry, 2004, vol. 28, # 2, p. 183 - 184
[4] Synthetic Communications, 2013, vol. 43, # 5, p. 758 - 767

Ethyl 3-(benzylamino)propanoate Preparation Products And Raw materials

Raw materials

Benzylamine Methanol Ethyl acrylate

Preparation Products

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Ethyl 3-(benzylamino)propanoate Suppliers

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View Lastest Price from Ethyl 3-(benzylamino)propanoate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 3-(benzylamino)propanoate 23583-21-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-12

Career Henan Chemical Co

Product: Ethyl 3-(benzylamino)propanoate 23583-21-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-08

23583-21-3, Ethyl 3-(benzylamino)propanoateRelated Search:

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N-Benzyl-beta-alanine Ethyl Ester N-Benzyl-3-aminopropionic Acid Ethyl Ester

Ethyl 3-(BenzylaMino)propionate , 95.0%(GC)

Ethyl 3-(benzylamino)propionate 97%

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Bzl-beta-Ala-OEt~Ethyl 3-(benzylamino)propionate

ethyl N-benzyl-beta-alaninate

ETHYL N-BENZYL-3-AMINOPROPIONATE

ETHYL 3-(BENZYLAMINO)PROPANOATE

ETHYL 3-(BENZYLAMINO)PROPIONATE

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benzylaminopropionicacidethylester

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bzl-á-ala-oet

n-benzyl-á-alanine ethyl ester

N-BENZYL-SS-ALANINE ETHYL ESTER

N-Benzyl-β-alanine ethyl ester, 98%

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Ethyl 4-(benzylamino)propanoate

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Ethyl 3-(Benzylamino)propionate &gt

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Ethyl 3-(benzylamino)propanoate USP/EP/BP

N-Benzyl-β-alanine Ethyl Ester

β-Alanine, N-(phenylmethyl)-, ethyl ester

23583-21-3

C6H5CH2NHCH2CH2CO2CH2CH3

AMINE

Phenyls & Phenyl-Het

Aromatic Cinnamic Acids, Esters and Derivatives

Esters

Phenyls & Phenyl-Het