Vosoritide acetate
- Product Name
- Vosoritide acetate
- CAS No.
- 1480724-61-5
- Chemical Name
- Vosoritide acetate
- Synonyms
- vosoritide;unii-7se5582q2p;Vosoritide acetate
- CBNumber
- CB15508225
- Formula Weight
- 0
- MOL File
- Mol file
Vosoritide acetate Property
- form
- Solid
- color
- White to off-white
- Sequence
- H-Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH(Disulfide bridge:Cys23-Cys7)
Vosoritide acetate Chemical Properties,Usage,Production
Uses
Vosoritide acetate is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
Side effects
The most common side effects of Vosoritide acetate include injection site reactions (such as swelling, redness, itching, or pain), vomiting, and decreased blood pressure.
in vivo
Vosoritide (subcutaneous injection; 800 μg/kg; once daily; 20 d) treatment leads to improvement in skeletal parameters in Fgfr3 gain-of-function mutation mouse[3].
| Animal Model: | Fgfr3Y367C/+ mice[3] |
| Dosage: | 800 μg/kg |
| Administration: | Subcutaneous injection; 800 μg/kg; once daily; 20 days |
| Result: | Observed phenotypic changes including flattening of the skull, elongation of the snout, improvement of the anterior crossbite, larger paws and digits, and longer and straightened tibias and femurs. |
References
[1] Duggan S. Vosoritide: First Approval. Drugs. 2021 Nov;81(17):2057-2062. DOI:10.1007/s40265-021-01623-w
[2] Shuhaibar LC, et al. Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. JCI Insight. 2021 May 10;6(9):e141426. DOI:10.1172/jci.insight.141426
[3] Lorget F, et al. Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am J Hum Genet. 2012 Dec 7;91(6):1108-14. DOI:10.1016/j.ajhg.2012.10.014
Vosoritide acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Vosoritide acetate Suppliers
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- +1-631-485-4226
- Fax
- 1-631-614-7828
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- Country
- United States
- ProdList
- 19552
- Advantage
- 58
View Lastest Price from Vosoritide acetate manufacturers
- Product
- Vosoritide acetate 1480724-61-5
- Price
- US $1.00/g
- Min. Order
- 0.10000000g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2025-11-06
- Product
- Vosoritide acetate 1480724-61-5
- Price
- US $1000.00-12000.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2025-06-20
- Product
- Vosoritide Acetate 1480724-61-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2025-04-01