2-Methoxy-4-nitroaniline

Product Name: 2-Methoxy-4-nitroaniline
CAS No.: 97-52-9
Chemical Name: 2-Methoxy-4-nitroaniline
Synonyms: FAST RED B BASE;FAST RED B;RED B BASE;2-AMINO-5-NITROANISOLE;RED B ASE;METHOXY-4-NITROANILINE;4-NITRO-ORTHO-ANISIDINE;AZOIC DIAZO COMPONENT 5;4-NITRO-2-METHOXYANILINE;2-Methoxy-4-nitrobenzenamine
CBNumber: CB1693973
Molecular Formula: C7H8N2O3
Formula Weight: 168.15
MOL File: 97-52-9.mol

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2-Methoxy-4-nitroaniline Property

Melting point:: 140-142 °C(lit.)
Boiling point:: 337.07°C (rough estimate)
Density: 1,211 g/cm³
refractive index: 1.6010 (estimate)
storage temp.: Store below +30°C.
solubility: 0.2g/l
pka: 1.02±0.10(Predicted)
form: Crystalline Powder
color: Yellow to orange
PH: 6.2 (0.2g/l, H2O, 20℃)
Water Solubility: slightly soluble
BRN: 879619
InChIKey: GVBHRNIWBGTNQA-UHFFFAOYSA-N
CAS DataBase Reference: 97-52-9(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 2-methoxy-4-nitro-(97-52-9)
EPA Substance Registry System: 2-Methoxy-4-nitroaniline (97-52-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-37/39-36/37
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2
RTECS: BZ7170000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29222900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 112631
Product name: 2-Methoxy-4-nitroaniline
Purity: 98%
Packaging: 100g
Price: $60.2
Updated: 2024/03/01

TCI Chemical

Product number: M0118
Product name: 2-Methoxy-4-nitroaniline
Purity: >99.0%(GC)
Packaging: 25g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: M0118
Product name: 2-Methoxy-4-nitroaniline
Purity: >99.0%(GC)
Packaging: 500g
Price: $193
Updated: 2024/03/01

Alfa Aesar

Product number: B24220
Product name: 2-Methoxy-4-nitroaniline, 99%
Packaging: 25g
Price: $18.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24220
Product name: 2-Methoxy-4-nitroaniline, 99%
Packaging: 100g
Price: $32.65
Updated: 2024/03/01

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2-Methoxy-4-nitroaniline Chemical Properties,Usage,Production

Chemical Properties

2-Methoxy-4-nitroaniline is a yellow to orange crystalline powder. 2-Methoxy-4-nitroaniline (MONA) is a potential nonlinear optical (NLO) material, the N12–O19 bond length of MONA molecule is essentially controlled by the p-character of these hybrid orbitals and also by the nature of the N12–O19 bond. The molecular geometry of the compound is almost planar with the substituents[1].

Uses

2-Methoxy-4-nitroaniline is an important intermediate for preparing organic pigments and color bases of ice dyeing dyestuff. As a benzene dye intermediate, It is generally employed to prepare not only fast pigments but also as a printing and dyeing developer for cotton fabrics. In particular, 2-methoxy-4-nitroaniline is also important in production of some antineoplastic drugs[2-3].

Uses

2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.

General Description

2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice.

Solubility in organics

The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol > ethylene glycol (EG) > n-butanol > water[2].

References

[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460.

2-Methoxy-4-nitroaniline Preparation Products And Raw materials

Raw materials

o-Anisidine dilute sulphuric acid P-toluenesulfonyl chloride Nitrification Tosyl chloride PARA TOLUENE Nitric acid Acetic acid

Preparation Products

4-Fluoro-3-methoxyaniline C.I.Pigment Yellow 98 5-CHLORO-2-NITROANISOLE 8-METHOXYQUINOLIN-6-AMINE

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2-Methoxy-4-nitroaniline Suppliers

Americas 1 Belgium 1 China 212 Czech Republic 1 Europe 2 Germany 3 India 36 Indonesia 1 Japan 4 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 10 United States 29 Global 305

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View Lastest Price from 2-Methoxy-4-nitroaniline manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 2-Methoxy-4-nitroaniline 97-52-9
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000KG
Release date: 2023-08-25

Qingdao RENAS Polymer Material Co., Ltd.

Product: Brilliant Red Developing Base 4B 97-52-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-08-27

Qingdao RENAS Polymer Material Co., Ltd.

Product: Brilliant Red Developing Base 4B 97-52-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-09-29

97-52-9, 2-Methoxy-4-nitroanilineRelated Search:

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-Amino-5-nitrophenyl methyl ether

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