ChemicalBook > CAS DataBase List > 4-IODO-7-AZAINDOLE

4-IODO-7-AZAINDOLE

Product Name
4-IODO-7-AZAINDOLE
CAS No.
319474-34-5
Chemical Name
4-IODO-7-AZAINDOLE
Synonyms
4-IODO-7-AZAINDOLE;4-IODO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 4-iodo-
CBNumber
CB1737396
Molecular Formula
C7H5IN2
Formula Weight
244.03
MOL File
319474-34-5.mol
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4-IODO-7-AZAINDOLE Property

Density 
2.082
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
13.08±0.40(Predicted)
Appearance
Light brown to yellow Solid
InChI
InChI=1S/C7H5IN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
InChIKey
PCHGYPNRADCIKG-UHFFFAOYSA-N
SMILES
C12NC=CC1=C(I)C=CN=2
CAS DataBase Reference
319474-34-5
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000928
Product name
4-Iodo-1H-pyrrolo[2,3-b]pyridine
Purity
Aldrich
Packaging
1g
Price
$817
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
HCH0040914
Product name
4-IODO-1H-PYRROLO[2,3-B]PYRIDINE
Purity
95.00%
Packaging
100MG
Price
$837.38
Updated
2021/12/16
AK Scientific
Product number
W5380
Product name
4-Iodo-7-azaindole
Packaging
1g
Price
$848
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-H-58
Product name
4-Iodo-7-azaindole
Packaging
1g
Price
$675
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-H-58
Product name
4-Iodo-7-azaindole
Packaging
250mg
Price
$225
Updated
2021/12/16
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4-IODO-7-AZAINDOLE Chemical Properties,Usage,Production

Synthesis

55052-28-3

319474-34-5

Part 2: Synthesis of 4-iodo-1H-pyrrolo[2,3-b]pyridine: To a mixture of 4-chloro-1H-pyrrolo[2,3-b]pyridine (12.9 g, 84.3 mmol) and NaI (40 g, 168 mmol) in acetonitrile (150 mL) was slowly added acetyl chloride (12.6 mL, 176 mmol). The reaction mixture was stirred at 80 °C for 4 days, followed by removal of excess acetonitrile by distillation under reduced pressure. To the residue was added 300 mL of 10% K2CO3 (aqueous solution) and extracted with CH2Cl2 (3 x 100 mL). The combined organic phases were washed sequentially with 10% sodium bisulfite (aqueous) and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (22.2 g). The crude product was dissolved in THF (150 mL) and 1 M NaOH (100 mL) was added. The mixture was stirred at room temperature for 2 h. The solvent was subsequently evaporated under reduced pressure, diluted with water and extracted with CH2Cl2. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting brown solid was purified by silica gel column chromatography and recrystallized with acetonitrile to give pure 4-iodo-1H-pyrrolo[2,3-b]pyridine (9.75 g, 48% yield). Mass spectrum (ES+): 245 [MH+].

References

[1] Journal of Medicinal Chemistry, 2018,
[2] Tetrahedron Letters, 2007, vol. 48, # 9, p. 1527 - 1529
[3] Patent: US2004/186124, 2004, A1. Location in patent: Page/Page column 14
[4] Patent: US2011/282056, 2011, A1. Location in patent: Page/Page column 16
[5] Patent: WO2014/121883, 2014, A1. Location in patent: Page/Page column 54

4-IODO-7-AZAINDOLE Preparation Products And Raw materials

Raw materials

7-Azaindole 3-Chloroperoxybenzoic acid Phosphorus oxitrichloride Sodium iodide

Preparation Products

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4-IODO-7-AZAINDOLE Suppliers

China 93 Germany 1 India 2 United States 10 Global 106
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
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62
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
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Email
info@synthonix.com
Country
United States
ProdList
6872
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58
Combi-Blocks Inc.
Tel
--
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--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
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--
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United States
ProdList
6773
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87
Matrix Scientific
Tel
--
Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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80
Adesis, Inc.
Tel
--
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Email
info@adesisinc.com
Country
United States
ProdList
512
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64
Sinova Inc.
Tel
--
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Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
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View Lastest Price from 4-IODO-7-AZAINDOLE manufacturers

Career Henan Chemical Co
Product
4-IODO-7-AZAINDOLE 319474-34-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-03

319474-34-5, 4-IODO-7-AZAINDOLERelated Search:

3-IODO-7-AZAINDOLE 1-BOC-3-IODO-7-AZAINDOLE 5-Bromo-3-iodo-7-azaindole 7-BROMO-4-CHLORO-3-IODO-5-AZAINDOLE 3-IODO-6-AZAINDOLE 5-IODO-7-AZAINDOLE 5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-CHLORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-FLUORO-4-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE 4-IODO-7-AZAINDOLE 4-BROMO-6-CHLORO-3-IODO-7-AZAINDOLE 4-BROMO-3-IODO-5-AZAINDOLE 4,7-DIBROMO-3-IODO-5-AZAINDOLE 4-BROMO-7-CHLORO-3-IODO-5-AZAINDOLE 3-IODO-5-AZAINDOLE 6-BROMO-4-CHLORO-3-IODO-7-AZAINDOLE 4-CYANO-3-IODO-5-AZAINDOLE 3-IODO-5-AZAINDOLE-4-CARBOXYLIC ACID

  • 4-IODO-1H-PYRROLO[2,3-B]PYRIDINE
  • 1H-Pyrrolo[2,3-b]pyridine, 4-iodo-
  • 4-IODO-7-AZAINDOLE
  • 319474-34-5
  • Azaindoles