4-Methylthiazole-5-carboxylic acid
- Product Name
- 4-Methylthiazole-5-carboxylic acid
- CAS No.
- 20485-41-0
- Chemical Name
- 4-Methylthiazole-5-carboxylic acid
- Synonyms
- TIMTEC-BB SBB010167;CHEMBRDG-BB 4402151;IFLAB-BB F2124-0222;4-METHYLTHIAZOLE-5-CARBOXYLATE;isoquinolin-5-yl-5-boronic acid;5-Carboxy-4-methyl-1,3-thiazole;4-methyl-5-thiazolecarboxylicaci;4-methyl-5-thiazolecarboxylicacid;4-METHYLTHIAZOLE-5-CARBOXYLIC ACID;4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC
- CBNumber
- CB1770874
- Molecular Formula
- C5H5NO2S
- Formula Weight
- 143.16
- MOL File
- 20485-41-0.mol
4-Methylthiazole-5-carboxylic acid Property
- Melting point:
- 287 °C (dec.) (lit.)
- Boiling point:
- 303.6±22.0 °C(Predicted)
- Density
- 1.338 (estimate)
- refractive index
- 1.5480 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO
- form
- solid
- pka
- 1.16±0.31(Predicted)
- color
- Off-White
- InChIKey
- ZGWGSEUMABQEMD-UHFFFAOYSA-N
- CAS DataBase Reference
- 20485-41-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 43-36/37/38
- Safety Statements
- 37/39-26
- WGK Germany
- 3
- RTECS
- XJ3680000
- HazardClass
- IRRITANT
- HS Code
- 29341000
N-Bromosuccinimide Price
- Product number
- 633666
- Product name
- 4-Methylthiazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $68.5
- Updated
- 2023/06/20
- Product number
- 633666
- Product name
- 4-Methylthiazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $498
- Updated
- 2023/06/20
- Product number
- M2235
- Product name
- 4-Methylthiazole-5-carboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- M330310
- Product name
- 4-Methylthiazole-5-carboxylic Acid
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR11384
- Product name
- 4-Methyl-1,3-thiazole-5-carboxylicacid
- Purity
- 95%
- Packaging
- 100g
- Price
- $215
- Updated
- 2021/12/16
4-Methylthiazole-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
4-Methylthiazole-5-carboxylic acid is used as a reagent to synthesize thiazolylimidazolidinone compounds that act as Stearoyl-CoA desaturase-1 (SCD1) inhibitors. These SCD1 inhibitors are used in the treatment of metabolic diseases. 4-Methylthiazole-5-carboxylic acid is also used as a reagent to synthesize 4-Methyl-5-formylthiazole, an important intermediate in the synthesis of Cefditoren pivoxil (C242700).
Definition
ChEBI: 4-Methyl-thiazole-5-carboxylic acid is an aromatic carboxylic acid and a member of thiazoles.
Synthesis
77287-34-4
609-15-4
20485-41-0
A mechanical stirrer, thermometer and constant pressure dropping funnel were assembled in a 10 L glass reactor and 1 mole of phosphorus pentasulfide (P4S10) and 6 kg of ethylene glycol dimethyl ether were added as solvent under nitrogen protection. Under stirring conditions, 5 moles of formamide was slowly added dropwise and the reaction lasted for 2 hours. Subsequently, 5 moles of ethyl 2-chloroacetoacetate was added dropwise and the reaction was carried out at room temperature for 608 hours. Upon completion of the reaction, the reaction mixture was cooled to 10 °C and the white solid product was collected by filtration. The solid product was dissolved in 4 times its weight in water and the pH was adjusted to 7-8 with 20% sodium hydroxide solution. filtration at 0-5 °C gave ethyl 4-methylthiazole-5-carboxylate as a white solid with 99% purity and 95.8% molar yield.
References
[1] Patent: CN105130924, 2017, B. Location in patent: Paragraph 0021; 0022
4-Methylthiazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methylthiazole-5-carboxylic acid Suppliers
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View Lastest Price from 4-Methylthiazole-5-carboxylic acid manufacturers
- Product
- 4-Methylthiazole-5-carboxylic Acid 20485-41-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-08-16
- Product
- 4-Methylthiazole-5-carboxylic acid 20485-41-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- 4-Methyl-5-Thiazolecarboxylic Acid 20485-41-0
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21