ChemicalBook > CAS DataBase List > 3,5-Dimethyl-4-methoxybenzoic acid

3,5-Dimethyl-4-methoxybenzoic acid

Product Name
3,5-Dimethyl-4-methoxybenzoic acid
CAS No.
21553-46-8
Chemical Name
3,5-Dimethyl-4-methoxybenzoic acid
Synonyms
TB023;3,5-DIMETHYL ANISIC ACID;3,5-DIMETHYL-4-ANISIC ICD;3,5-DIMETHYL-P-ANISIC ACID;3,5-DIMETHYL-4-ANISIC ACID;3,5-Dimethyl-4-Methoxybenzoic;4-methoxy-3,5-dimethylbenzoate;3,5-Dimethyl-p-anisic acid,98%;3,5-DIMETHYL-P-ANISIC ACID 98%;,5-diMethyl-4-Methoxybenzoic acid
CBNumber
CB1780569
Molecular Formula
C10H12O3
Formula Weight
180.2
MOL File
21553-46-8.mol
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3,5-Dimethyl-4-methoxybenzoic acid Property

Melting point:
191-195 °C (lit.)
Boiling point:
253.02°C (rough estimate)
Density 
1.1185 (rough estimate)
refractive index 
1.5392 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
4.61±0.10(Predicted)
form 
Crystalline Solid
color 
White to brown
CAS DataBase Reference
21553-46-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
HazardClass 
6.1
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
638692
Product name
3,5-Dimethyl-4-methoxybenzoic acid
Purity
97%
Packaging
1g
Price
$87.4
Updated
2022/05/15
Sigma-Aldrich
Product number
638692
Product name
3,5-Dimethyl-4-methoxybenzoic acid
Purity
97%
Packaging
5g
Price
$192
Updated
2022/05/15
TCI Chemical
Product number
M2139
Product name
4-Methoxy-3,5-dimethylbenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
M2139
Product name
4-Methoxy-3,5-dimethylbenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$112
Updated
2025/07/31
TRC
Product number
D474985
Product name
3,5-Dimethyl-4-methoxybenzoic acid
Packaging
500mg
Price
$60
Updated
2021/12/16
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3,5-Dimethyl-4-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to brown crystalline solid

Synthesis

152775-45-6

21553-46-8

General procedure for the synthesis of 3,5-dimethyl-4-methoxybenzoic acid from 4-methoxy-3,5-dimethylbenzenecarbonitrile: 4-methoxy-3,5-dimethylbenzenecarbonitrile (1664 mg) was suspended in ethanol (32 mL), to which 8M NaOH solution (163 mL) was added. The mixture was placed in a pressure reactor and the reaction was stirred at 120 °C overnight. Upon completion of the reaction, ethanol was removed by rotary evaporation. Water was added to the residue and the aqueous solution was washed with ether to remove non-polar impurities. Subsequently, the aqueous layer was acidified with concentrated hydrochloric acid to pH < 2, at which point the target product precipitated as a solid. The acidified aqueous layer was extracted with ethyl acetate and the organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to afford 3,5-dimethyl-4-methoxybenzoic acid as a white solid in 99% yield.LRMS (m/z): 181 ([M+H]+).HPLC retention time: 5.52 min (Method B).

References

[1] Patent: WO2011/144338, 2011, A1. Location in patent: Page/Page column 92
[2] Patent: EP2390252, 2011, A1. Location in patent: Paragraph 0449; 0450

3,5-Dimethyl-4-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Dimethyl-4-methoxybenzoic acid Suppliers

Americas 1 Belgium 1 China 99 Europe 4 Germany 3 India 3 Japan 2 Slovakia 1 Switzerland 3 Ukraine 2 United Kingdom 11 United States 22 Global 152
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 3,5-Dimethyl-4-methoxybenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Dimethyl-4-methoxybenzoic acid 21553-46-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-02
Honest Joy Holdings Limited
Product
3,5-Dimethyl-4-methoxybenzoicacid 21553-46-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
3,5-Dimethyl-4-methoxybenzoic acid 21553-46-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-30

21553-46-8, 3,5-Dimethyl-4-methoxybenzoic acidRelated Search:

Dimethyl carbonate Anisole ETHANE Dimethyl sulfate (Trifluoromethoxy)benzene 3,5-Dimethylbenzoic acid Dimethyl ether 3,4-Dimethylaniline Protocatechuic acid 3,5-Dimethoxybenzoic acid 2,6-Dimethoxybenzoic acid Dacthal 4-Methoxybenzoic acid p-Anisidine Xylene 2,4-Dimethyl aniline N,N-Dimethylformamide Methoxyacetic acid

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