ChemicalBook > CAS DataBase List > Imidapril

Imidapril

Product Name
Imidapril
CAS No.
89371-37-9
Chemical Name
Imidapril
Synonyms
IMIDAPRIL;lmidaprfil;Imidapril HCl;Imidapril Hyd;Imidapril-d5 HCl;(S,S,S)-Imidapril;Imidapril USP/EP/BP;IMidapril (Tanatril);(s)-3-(n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid;(4S)-3-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
CBNumber
CB1780943
Molecular Formula
C20H27N3O6
Formula Weight
405.44
MOL File
89371-37-9.mol
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Imidapril Property

Melting point:
195-197°C
alpha 
D20 -71.7° (c = 0.5 in ethanol)
Boiling point:
577.0±60.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
form 
Solid
pka
2.44±0.20(Predicted)
color 
White to off-white
CAS DataBase Reference
89371-37-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006470
Product name
IMIDAPRIL
Purity
95.00%
Packaging
10MG
Price
$191.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006470
Product name
IMIDAPRIL
Purity
95.00%
Packaging
100MG
Price
$1593.9
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11104
Product name
ImidaprilHCl
Packaging
50mg
Price
$1880
Updated
2021/12/16
AvaChem
Product number
1689B
Product name
Imidapril
Packaging
10mg
Price
$59
Updated
2021/12/16
AvaChem
Product number
1689B
Product name
Imidapril
Packaging
25mg
Price
$119
Updated
2021/12/16
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Imidapril Chemical Properties,Usage,Production

Description

Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at a considerably lower dose than enalapril. This stroke preventive effect has been suggested to be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.

Chemical Properties

White Solid

Originator

Tanabe (Japan)

Uses

Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive

Definition

ChEBI: Imidapril is a member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It is a dipeptide, a member of imidazolidines, a dicarboxylic acid monoester, a secondary amino compound, an ethyl ester and a N-acylurea.

brand name

Tanatril; Novarok

Imidapril Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Potassium tert-butoxide Ethyl butyrate Benzyl ester 4-Phenylbutyric acid Propionyl chloride Midazopril hydrochloride 1-Methylpyrazole-4-ethoxycarbonyl-5-ethoxycarbonylsulfonamide Bromobenzene Imidazolidine Aniline D-Alanine Tert-butyl ester Iodomethane (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline

Preparation Products

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Imidapril Suppliers

Canada 1 China 85 Europe 2 India 5 United Kingdom 3 United States 19 Global 115
LGM Pharma
Tel
1-(800)-881-8210
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615-250-9817
Email
inquiries@lgmpharma.com
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United States
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2123
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70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
ProdList
14055
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65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19881
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
Alfa Chemistry
Tel
--
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Country
United States
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6814
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0
CarboMer, Inc.
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--
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sales@carbomer.com
Country
United States
ProdList
4026
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67
AlliChem, LLC
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--
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sales@allichemllc.com
Country
United States
ProdList
6516
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60
CacheSyn Inc.
Tel
--
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Email
info@cachesyn.com
Country
United States
ProdList
695
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50
Santa Cruz Biotechnology, Inc.
Tel
--
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Email
scbt@scbt.com
Country
United States
ProdList
3597
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60
Labseeker Inc
Tel
--
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marketing@labseeker.com
Country
United States
ProdList
1495
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Medical Isotopes
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stohler@medicalisotopes.com
Country
United States
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6181
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Waterstone Technology, LLC
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United States
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6786
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2A PharmaChem USA
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sales@2apharmachem.com
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United States
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3B Scientific Corporation
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sales@3bsc.com
Country
United States
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AK Scientific, Inc.
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sales@aksci.com
Country
United States
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APAC Pharmaceutical, LLC
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ChemPacific Corporation
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sales@chempacific.com
Country
United States
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View Lastest Price from Imidapril manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Imidapril Hydrochloride 89371-37-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kgs
Release date
2021-10-18
Shaanxi Dideu Medichem Co. Ltd
Product
Imidapril 89371-37-9
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09
Career Henan Chemical Co
Product
Imidapril 89371-37-9
Price
US $20.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20kg
Release date
2018-07-27

89371-37-9, ImidaprilRelated Search:

Methanol Lithium diisopropylamide Basic Violet 1 Methyl acetate Acetonitrile Methyl acrylate Methylparaben Kresoxim-methyl Paraquat dichloride 1,1'-Carbonyldiimidazole 1-(2,6-Dimethylphenoxy)-2-propanamine Methyl Methyl bromide Carbonyl iron powder NICKEL CARBONYL 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE Imidapril Diacid N-ISOPROPYL-AMINO-ACETIC ACID ETHYL ESTER HCL

  • (s)-3-(n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid
  • IMIDAPRIL
  • (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Aci
  • 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, (4S)-
  • 4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, [4S-[3[R*(R*)],4R*]]-
  • (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Acid Hydrochloride
  • (4S)-3-[(2S)-2-[N-[(1S)-1-(Ethyoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
  • lmidaprfil
  • (4S)-3-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid
  • (4S)-3-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
  • (S,S,S)-Imidapril
  • Imidapril HCl
  • IMidapril (Tanatril)
  • Imidapril-d5 HCl
  • Imidapril USP/EP/BP
  • Imidapril Hyd
  • 89371-37-9
  • 9371-37-9
  • C20H27N3O6
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals