cis-4-Hydroxy-D-proline hydrochloride

Uses Synthetic Application

Product Name: cis-4-Hydroxy-D-proline hydrochloride
CAS No.: 77449-94-6
Chemical Name: cis-4-Hydroxy-D-proline hydrochloride
Synonyms: cis-D-Hyp-OH.HCl;H-D-cis-Hyp-OH.HCL;Cis-4-OH-D-pro-OH·HCl;CIS-4-HYDROXY-D-PROLINE HCL;D-Proline, 4-hydroxy-,hydrochloride;cis-4-Hydroxy-D-proline hydrochloride;cis-4-Hydro×y-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;D-Proline, 4-hydroxy-,hydrochloride (1:1);Cis-4-hydroxy-D-proline monohydrochloride
CBNumber: CB1947559
Molecular Formula: C5H10ClNO3
Formula Weight: 167.5908
MOL File: 77449-94-6.mol

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cis-4-Hydroxy-D-proline hydrochloride Property

Melting point:: 114-116 °C
storage temp.: Inert atmosphere,Room Temperature
form: Solid
color: White to off-white
InChI: InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/s3
InChIKey: YEJFFQAGTXBSTI-QYDODFSFNA-N
SMILES: C(O)(=O)[C@H]1C[C@@H](O)CN1.[H]Cl |&1:3,5,r|

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H952393
Product name: Cis-4-Hydroxy-D-prolinehydrochloride
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J96651
Product name: cis-4-Hydroxy-D-prolinehydrochloride
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 074556
Product name: cis-4-Hydroxy-D-proline hydrochloride
Purity: 95+%
Packaging: 5g
Price: $121
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-5-4C
Product name: cis-4-Hydroxy-D-proline hydrochloride
Purity: 97.0%
Packaging: 5G
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-5-4C
Product name: cis-4-Hydroxy-D-proline hydrochloride
Purity: 97.0%
Packaging: 25g
Price: $190
Updated: 2021/12/16

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cis-4-Hydroxy-D-proline hydrochloride Chemical Properties,Usage,Production

Uses

Cis-4-Hydroxy-D-proline belongs to the class of organic compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from a reaction of proline at the amino group or the carboxyl group, or from the replacement of any hydrogen of glycine by a heteroatom. cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase.

Synthetic Application

Cis-4-Hydroxy-D-proline may be used as a starting material for the 13-step synthesis of new conformationally restricted PNA adenine monomer and the synthesis of N-Benzyl pyrrolidinyl sordaricin derivatives. Cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase. Cis-4-Hydroxy-D-proline may be used to analyze the substrate specificity of amino acid transporter PAT1.

Synthesis

A mixture of (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacid(50 mmol, 6550 mg) and Ac2O (250 mmol, 23.5 mL) in AcOH (100 mL) wasstirred at reflux for 6 h. The resulting mixture was concentrated to give thecrude intermediate. The solution of this crude intermediate in 2 N HCl (50 mL)was stirred at reflux for 3 h. Then activated charcoal (1 g) was added, the hotmixture was ltered immediately through a Celite layer. The filtrate was concentrated in vacuo to give the crude intermediate.The crude intermediate was dissolved in acetone and filtered. The residue was washed twice with ether anddried in vacuo to give cis-4-Hydroxy-D-proline hydrochloride as a white solid (7.54 g, 90percent).

cis-4-Hydroxy-D-proline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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cis-4-Hydroxy-D-proline hydrochloride Suppliers

China 135 India 5 United States 16 Global 156

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View Lastest Price from cis-4-Hydroxy-D-proline hydrochloride manufacturers

Career Henan Chemical Co

Product: cis-4-Hydroxy-D-proline hydrochloride 77449-94-6
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 97-99%
Supply Ability: 1000KGS
Release date: 2019-12-19

77449-94-6, cis-4-Hydroxy-D-proline hydrochlorideRelated Search:

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cis-4-Hydroxy-D-proline hydrochloride

CIS-4-HYDROXY-D-PROLINE HCL

(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride

cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride)

cis-4-Hydro×y-D-proline hydrochloride

(2R,4R)-4-hydroxyproline hydrochloride

cis-D-Hyp-OH.HCl

H-D-cis-Hyp-OH.HCL

Cis-4-OH-D-pro-OH·HCl

(2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid hydrochlorid

D-Proline, 4-hydroxy-,hydrochloride (1:1)

Cis-4-hydroxy-D-proline monohydrochloride

(2R,4R)-cis-4-hydroxy-D-proline hydrochloride

cis-4-Hydroxy-D-proline hydrochloride USP/EP/BP

D-Proline, 4-hydroxy-,hydrochloride

(4R)-4-Hydroxy-D-proline hydrochloride (1:1)

77449-94-6