ChemicalBook > CAS DataBase List > N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE

N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE

Product Name
N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
CAS No.
261766-32-9
Chemical Name
N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
Synonyms
N-2PIA;LM 4108;Indomethacin N-Phenylethyl Impurity;N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE;N-(2-PHENYLETHYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(2-PHENYLETHYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
CBNumber
CB2125110
Molecular Formula
C27H25ClN2O3
Formula Weight
460.95
MOL File
Mol file
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N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Property

Boiling point:
640.5±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
≤80mg/ml in ethanol;10mg/ml in DMSO;14mg/ml in dimethyl formamide
form 
Pale yellow solid.
pka
15.12±0.46(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70272
Product name
N-(2-phenylethyl)-Indomethacin amide
Purity
≥98%
Packaging
1mg
Price
$18
Updated
2024/03/01
Cayman Chemical
Product number
70272
Product name
N-(2-phenylethyl)-Indomethacin amide
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
70272
Product name
N-(2-phenylethyl)-Indomethacin amide
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
70272
Product name
N-(2-phenylethyl)-Indomethacin amide
Purity
≥98%
Packaging
50mg
Price
$553
Updated
2024/03/01
TRC
Product number
P321250
Product name
N-(2-Phenylethyl)indomethacinAmide
Packaging
50mg
Price
$140
Updated
2021/12/16
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N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively

Uses

N-(2-Phenylethyl)indomethacin Amide is an aromatic amide of indomethacin reported to be a potent and selective reversible inhibitor of COX-2. N-(2-Phenylethyl)indomethacin Amide inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively.

Definition

ChEBI: N-(2-phenylethyl)-Indomethacin amide is a N-acylindole.

Biological Activity

n-(2-phenylethyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(2-phenylethyl)-indomethacin amide (n-2pia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.06 and >66 μm, respectively. it is over 1000 times less potent as an inhibitor of ovine cox-1. n-(2-phenylethyl)-indomethacin amide is an analogous derivative of indomethacin that shows selective against cox-2 [1].in the carageenan-induced foot pad edema assay, orally administration of n-2pia showed anti-inflammatory activity [1].

IC 50

Human COX-2: 60 nM (IC50); Ovine COX-1: >66 μM (IC50)

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Suppliers

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261766-32-9, N-(2-PHENYLETHYL)-INDOMETHACIN AMIDERelated Search:

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  • N-(2-PHENYLETHYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE
  • N-2PIA
  • N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
  • LM 4108
  • 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide
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  • 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
  • 261766-32-9
  • C27H25N2O3Cl
  • CyclooxygenaseEnzyme Inhibitors by Enzyme
  • A to
  • Arachidonic Acid Cascade
  • Enzyme Inhibitors
  • Inhibitors
  • Cyclooxygenase (COX) Enzymes
  • Cyclooxygenase Inhibitors
  • CyclooxygenaseCell Signaling Enzymes