N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
- Product Name
- N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
- CAS No.
- 261766-32-9
- Chemical Name
- N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
- Synonyms
- N-2PIA;LM 4108;Indomethacin N-Phenylethyl Impurity;N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE;N-(2-PHENYLETHYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(2-PHENYLETHYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
- CBNumber
- CB2125110
- Molecular Formula
- C27H25ClN2O3
- Formula Weight
- 460.95
- MOL File
- Mol file
N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Property
- Boiling point:
- 640.5±55.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ≤80mg/ml in ethanol;10mg/ml in DMSO;14mg/ml in dimethyl formamide
- form
- Pale yellow solid.
- pka
- 15.12±0.46(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 70272
- Product name
- N-(2-phenylethyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $18
- Updated
- 2024/03/01
- Product number
- 70272
- Product name
- N-(2-phenylethyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 70272
- Product name
- N-(2-phenylethyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 70272
- Product name
- N-(2-phenylethyl)-Indomethacin amide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $553
- Updated
- 2024/03/01
- Product number
- P321250
- Product name
- N-(2-Phenylethyl)indomethacinAmide
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production
Uses
An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively
Uses
N-(2-Phenylethyl)indomethacin Amide is an aromatic amide of indomethacin reported to be a potent and selective reversible inhibitor of COX-2. N-(2-Phenylethyl)indomethacin Amide inhibits human recombinant and ovine COX-2 with IC50 of 0.06 uM and 0.125 uM, respectively.
Definition
ChEBI: N-(2-phenylethyl)-Indomethacin amide is a N-acylindole.
Biological Activity
n-(2-phenylethyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(2-phenylethyl)-indomethacin amide (n-2pia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.06 and >66 μm, respectively. it is over 1000 times less potent as an inhibitor of ovine cox-1. n-(2-phenylethyl)-indomethacin amide is an analogous derivative of indomethacin that shows selective against cox-2 [1].in the carageenan-induced foot pad edema assay, orally administration of n-2pia showed anti-inflammatory activity [1].
References
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.