4-Bromo-2,3-difluorophenol
- Product Name
- 4-Bromo-2,3-difluorophenol
- CAS No.
- 144292-32-0
- Chemical Name
- 4-Bromo-2,3-difluorophenol
- Synonyms
- 2FPBr;4-Bromo-2,3-difluoro;4-BROMO-2,3-DIFLUORPHENOL;4-BROMO-2,3-DIFLUOROPHENOL;2,3-DIFLUORO-4-BROMOPHENOL;Phenol, 4-bromo-2,3-difluoro-;4-Bromo-2,3-difluorophenol>2,3-DIFLUORO-4-BROMO PHENOL,=98%;4-Bromo-2,3-difluorophenol Aldrich;4-Bromo-2,3-difluorophenol AldrichCPR
- CBNumber
- CB2149886
- Molecular Formula
- C6H3BrF2O
- Formula Weight
- 208.99
- MOL File
- 144292-32-0.mol
4-Bromo-2,3-difluorophenol Property
- Melting point:
- 53.0 to 57.0 °C
- Boiling point:
- 213.3±35.0 °C(Predicted)
- Density
- 1.858±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.16±0.23(Predicted)
- form
- powder to crystal
- color
- White to Gray to Brown
- InChI
- InChI=1S/C6H3BrF2O/c7-3-1-2-4(10)6(9)5(3)8/h1-2,10H
- InChIKey
- JZAVCMMYGSROJP-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(Br)C(F)=C1F
- CAS DataBase Reference
- 144292-32-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D3913
- Product name
- 4-Bromo-2,3-difluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- D3913
- Product name
- 4-Bromo-2,3-difluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- B691273
- Product name
- 4-Bromo-2,3-difluorophenol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B691273
- Product name
- 4-Bromo-2,3-difluorophenol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2601-B-23
- Product name
- 4-Bromo-2,3-difluorophenol
- Purity
- 98%
- Packaging
- 10g
- Price
- $53
- Updated
- 2021/12/16
4-Bromo-2,3-difluorophenol Chemical Properties,Usage,Production
Chemical Properties
white solid
Uses
4-Bromo-2,3-difluorophenol is used as medical intermediate.
Synthesis
406482-22-2
144292-32-0
The general procedure for the synthesis of 2,3-difluoro-4-bromophenol from 4-bromo-2,3-difluoroanisole was as follows: to a stirred solution of 1-bromo-2,3-difluoro-4-methoxybenzene (3 g, 13.45 mmol) in dichloromethane (DCM, 30 mL) was slowly added dropwise to a dichloromethane (DCM) solution of 1 M boron tribromide (BBr3) (26.9) at -20 °C. The dropwise addition time was controlled to 10 min. mL, 26.9 mmol), and the dropwise addition time was controlled over 10 min. The cooling bath was removed and the reaction mixture was continued to be stirred at room temperature for 12 hours. Subsequently, the reaction mixture was cooled to 10 °C and the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL). The mixture was diluted with dichloromethane (DCM, 150 mL) and the organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-bromo-2,3-difluorophenol (2 g, 9.47 mmol, 70% yield) in the form of a dark red oil. NMR hydrogen spectrum (400MHz, chloroform-d): δ 7.15-7.21 (m, 1H), 6.69-6.76 (m, 1H), 5.30-5.31 (m, 1H) ppm.
References
[1] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 453
4-Bromo-2,3-difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2,3-difluorophenol Suppliers
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- info@pschemicals.com
- Country
- The Netherlands
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View Lastest Price from 4-Bromo-2,3-difluorophenol manufacturers
- Product
- 4-Bromo-2,3-difluorophenol 144292-32-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-29
- Product
- 4-Bromo-2,3-difluorophenol 144292-32-0
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customise
- Release date
- 2018-08-09