4-Bromo-2,3-difluorophenol

Product Name: 4-Bromo-2,3-difluorophenol
CAS No.: 144292-32-0
Chemical Name: 4-Bromo-2,3-difluorophenol
Synonyms: 2FPBr;4-Bromo-2,3-difluoro;4-BROMO-2,3-DIFLUORPHENOL;4-BROMO-2,3-DIFLUOROPHENOL;2,3-DIFLUORO-4-BROMOPHENOL;Phenol, 4-bromo-2,3-difluoro-;4-Bromo-2,3-difluorophenol>2,3-DIFLUORO-4-BROMO PHENOL,=98%;4-Bromo-2,3-difluorophenol Aldrich;4-Bromo-2,3-difluorophenol AldrichCPR
CBNumber: CB2149886
Molecular Formula: C6H3BrF2O
Formula Weight: 208.99
MOL File: 144292-32-0.mol

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4-Bromo-2,3-difluorophenol Property

Melting point:: 53.0 to 57.0 °C
Boiling point:: 213.3±35.0 °C(Predicted)
Density: 1.858±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 7.16±0.23(Predicted)
form: powder to crystal
color: White to Gray to Brown
InChI: InChI=1S/C6H3BrF2O/c7-3-1-2-4(10)6(9)5(3)8/h1-2,10H
InChIKey: JZAVCMMYGSROJP-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(Br)C(F)=C1F
CAS DataBase Reference: 144292-32-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
RIDADR: 2811
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3913
Product name: 4-Bromo-2,3-difluorophenol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: D3913
Product name: 4-Bromo-2,3-difluorophenol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $55
Updated: 2025/07/31

TRC

Product number: B691273
Product name: 4-Bromo-2,3-difluorophenol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B691273
Product name: 4-Bromo-2,3-difluorophenol
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2601-B-23
Product name: 4-Bromo-2,3-difluorophenol
Purity: 98%
Packaging: 1g
Price: $16
Updated: 2021/12/16

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4-Bromo-2,3-difluorophenol Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

4-Bromo-2,3-difluorophenol is used as medical intermediate.

Synthesis

406482-22-2

144292-32-0

The general procedure for the synthesis of 2,3-difluoro-4-bromophenol from 4-bromo-2,3-difluoroanisole was as follows: to a stirred solution of 1-bromo-2,3-difluoro-4-methoxybenzene (3 g, 13.45 mmol) in dichloromethane (DCM, 30 mL) was slowly added dropwise to a dichloromethane (DCM) solution of 1 M boron tribromide (BBr3) (26.9) at -20 °C. The dropwise addition time was controlled to 10 min. mL, 26.9 mmol), and the dropwise addition time was controlled over 10 min. The cooling bath was removed and the reaction mixture was continued to be stirred at room temperature for 12 hours. Subsequently, the reaction mixture was cooled to 10 °C and the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL). The mixture was diluted with dichloromethane (DCM, 150 mL) and the organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-bromo-2,3-difluorophenol (2 g, 9.47 mmol, 70% yield) in the form of a dark red oil. NMR hydrogen spectrum (400MHz, chloroform-d): δ 7.15-7.21 (m, 1H), 6.69-6.76 (m, 1H), 5.30-5.31 (m, 1H) ppm.

References

[1] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 453

4-Bromo-2,3-difluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2,3-difluorophenol Suppliers

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View Lastest Price from 4-Bromo-2,3-difluorophenol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-2,3-difluorophenol 144292-32-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-29

Career Henan Chemical Co

Product: 4-Bromo-2,3-difluorophenol 144292-32-0
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customise
Release date: 2018-08-09

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4-BROMO-2,3-DIFLUOROPHENOL

4-BROMO-2,3-DIFLUORPHENOL

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2,3-DIFLUORO-4-BROMO PHENOL,=98%

4-Bromo-2,3-difluorophenol 2,3-Difluoro-4-bromophenol

4-Bromo-2,3-difluoro

4-Bromo-2,3-difluorophenol AldrichCPR

4-Bromo-2,3-difluorophenol Aldrich

2FPBr

4-Bromo-2,3-difluorophenol&gt

Phenol, 4-bromo-2,3-difluoro-

4-Bromo-2,3-difluorophenol ISO 9001：2015 REACH

144292-32-0

Phenol&Thiophenol&Mercaptan

Aromatic Phenols