Polyinosinic-polycytidylic acid sodium salt

Product Name: Polyinosinic-polycytidylic acid sodium salt
CAS No.: 42424-50-0
Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Synonyms: Poly (I:C) Na;Poly(I:C) sodium;POLY I POLY C, NA;Polymyocyte sodium salt;POLY[I] POLY[C] SODIUM SALT;polyinosinic-polycytidylic acid sodium;polyI-polyC sodium salt compound solution;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;Polyinosinicacid-polycytidylicacidsodiumsal;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT
CBNumber: CB2187556
Molecular Formula: C19H27N7O16P2
Formula Weight: 671.41
MOL File: 42424-50-0.mol

More

Less

Polyinosinic-polycytidylic acid sodium salt Property

storage temp.: −20°C
solubility: H2O: soluble10mg/mL
form: lyophilized powder
color: White to off-white
biological source: synthetic (organic)
Water Solubility: Water : 10 mg/mL (Need ultrasonic and warming)
InChIKey: ACEVNMQDUCOKHT-WOQDZEJINA-N
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TR0175000

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0913
Product name: Polyinosinic–polycytidylic acid sodium salt
Purity: ≥99% (less than 1% free nucleotides, TLC)
Packaging: 10mg
Price: $139
Updated: 2025/07/31

Sigma-Aldrich

Product number: P0913
Product name: Polyinosinic–polycytidylic acid sodium salt
Purity: ≥99% (less than 1% free nucleotides, TLC)
Packaging: 50mg
Price: $473
Updated: 2025/07/31

Sigma-Aldrich

Product number: 528906
Product name: Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded - CAS 42424-50-0 - Calbiochem
Purity: Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0.
Packaging: 10MG
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: P1530
Product name: Polyinosinic–polycytidylic acid sodium salt
Purity: TLR ligand tested
Packaging: 25mg
Price: $217
Updated: 2025/07/31

Sigma-Aldrich

Product number: P1530
Product name: Polyinosinic–polycytidylic acid sodium salt
Purity: TLR ligand tested
Packaging: 100mg
Price: $649
Updated: 2025/07/31

More

Less

Polyinosinic-polycytidylic acid sodium salt Chemical Properties,Usage,Production

Description

Polyinosinic-polycytidylic acid (Poly I:C) sodium salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.

Uses

TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic-polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly I:C is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Biological Activity

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.

in vivo

Polyinosinic-polycytidylic acid (Poly I:C) treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid^[1].

IC 50

TLR3

storage

Store at -20°C

Polyinosinic-polycytidylic acid sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Polyinosinic-polycytidylic acid sodium salt Suppliers

China 138 Germany 1 Switzerland 1 United Kingdom 1 United States 10 USA 1 Global 152

HANGZHOU KAIPENG BIOTECHNOLOGY CO., LTD.

Tel: 0571-89939007
Email: kaipengbio@126.com
Country: China
ProdList: 10
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4456
Advantage: 55

Hubei kangen Pharmaceutical Chemical Co., Ltd

Tel: 153-15337215803 15337215803
Fax: 027-89771658
Email: 3357312443@qq.com
Country: China
ProdList: 695
Advantage: 56

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-0553-8233716-803-803 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 953
Advantage: 55

More

Less

View Lastest Price from Polyinosinic-polycytidylic acid sodium salt manufacturers

WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)

Product: Polyi polycytidylic acid sodium salt(Poly I:C) (PIC) 42424-50-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥90%
Supply Ability: 2tons
Release date: 2025-08-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Polyinosinic-polycytidylic acid sodium salt 42424-50-0
Price: US $0.00/g
Min. Order: 1g
Purity: 45%-55%
Supply Ability: 10kg/month
Release date: 2021-09-28

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Polyinosinic–polycytidylic acid sodium salt ; Poly (I: C); Poly (I:C) Na; 42424-50-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 90.0%Min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-10

42424-50-0, Polyinosinic-polycytidylic acid sodium saltRelated Search:

METHYL ISOCYANOACETATE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate Benzyl isocyanide Aluminum acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide N-BUTYLISOCYANIDE Cupric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE Polyinosinic acid

POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT

Polymyocyte sodium salt

POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT

POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT

POLY I POLY C, NA

POLY[I] POLY[C] SODIUM SALT

Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution

Polyinosinic acid - polycytidylic acid sodium salt, double-stranded

Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double

polyinosinic-polycytidylic acid sodium

Polyinosinic–polycytidylic Acid Sodium Salt（Poly I:C ）

polyI-polyC sodium salt compound solution

Poly(I:C) sodium

POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT USP/EP/BP

Polyi polycytidylic acid sodium salt(Poly I:C) (PIC)

Poly (I:C) Na

Polyinosinicacid-polycytidylicacidsodiumsal

Polyinosinic-polycytidylic acid sodium salt gamma-irradiated

42424-50-0

BioChemical

Biochemicals and Reagents

Synthetic Oligonucleotides and Related Reagents

Nucleosides, Nucleotides, Oligonucleotides

Biochemicals and Reagents

Biomaterials

Cell Culture

Materials Science

Nucleosides

Nucleotides

Oligonucleotide Polymers and Copolymers

Oligonucleotides

Other adjuvants

Synthetic Oligonucleotides and Related Reagents

Vaccine Adjuvants

Vaccine Production

Nucleoside Mono