ChemicalBook > CAS DataBase List > NVP-BEP800

NVP-BEP800

Product Name
NVP-BEP800
CAS No.
847559-80-2
Chemical Name
NVP-BEP800
Synonyms
CS-1973;VER82576;VER-82576;NVP-BEP800;NVP-BEP800 BEP-800;NVP-BEP800 USP/EP/BP;VER-82576 (NVP-BEP800);VER-82576;NVP BEP800;VER82576;2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
CBNumber
CB22506238
Molecular Formula
C21H23Cl2N5O2S
Formula Weight
480.41
MOL File
847559-80-2.mol
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NVP-BEP800 Property

Density 
1.396
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form 
Powder
pka
13.25±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18383
Product name
NVP-BEP800
Purity
≥98%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18383
Product name
NVP-BEP800
Purity
≥98%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
18383
Product name
NVP-BEP800
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18383
Product name
NVP-BEP800
Purity
≥98%
Packaging
10mg
Price
$281
Updated
2024/03/01
Usbiological
Product number
461049
Product name
NVP-BEP 800
Packaging
1mg
Price
$333
Updated
2021/12/16
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NVP-BEP800 Chemical Properties,Usage,Production

Uses

NVP-BEP 800 is a Hsp90 inhibitor which ehibits anti-proliferative effects against cancer cell lines with high expression level of Hsp90.

Biological Activity

nvp-bep800 is a fully synthetic, orally bioavailable inhibitor of hsp90 with ic50 value of 58nm [1].nvp-bep800 binds to the n-terminal atp-binding pocket of hsp90. in a competitive binding fluorescence polarization assay, nvp-bep800 inhibits hsp90β with ic50 value of 58nm. and to other 20 protein kinases, nvp-bep800 shows a ic50 of >10μm. in bt-474 cells and a375 cells, nvp-bep800 causes the hsp90-p23 dissociation and client protein degradation (erbb2) as well as the reduction of client protein phosphorylation (phospho-akt). degradation of these oncogenic client proteins results in tumor cell growth arrest and death. nvp-bep800 inhibits proliferation of tumor cells with an average gi50 of 245nm. and in 46 primary human tumors including small cell lung, mammary cancer and melanoma, the mean ic50 is 750nm. additionally, treatment of nvp-bep800 induces apoptosis in human breast cancer cell lines. the antitumor efficacy of nvp-bep800 is also observed with a dose of 15 or 30 mg/kg/d in a375 xenograft-bearing mice as well as in bt-474 breast cancer xenografts [1].

target

Hsp90β

References

[1] massey aj, schoepfer j, brough pa, brueggen j, chène p, drysdale mj, pfaar u, radimerski t, ruetz s, schweitzer a, wood m, garcia-echeverria c, jensen mr. preclinical antitumor activity of the orally available heat shock protein 90 inhibitor nvp-bep800. mol cancer ther. 2010 apr;9(4):906-19.

NVP-BEP800 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BEP800 Suppliers

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View Lastest Price from NVP-BEP800 manufacturers

Career Henan Chemical Co
Product
NVP-BEP800 847559-80-2
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-08-09

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  • NVP-BEP800
  • 2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
  • NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
  • 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
  • VER82576
  • VER-82576
  • 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800
  • NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
  • 2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-
  • CS-1973
  • VER-82576 (NVP-BEP800)
  • VER-82576;NVP BEP800;VER82576
  • NVP-BEP800 USP/EP/BP
  • NVP-BEP800 BEP-800
  • Thieno[2,3-d]pyrimidine-6-carboxamide, 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl-
  • 847559-80-2
  • C21H23Cl2N5O2S
  • Inhibitor
  • apis
  • Inhibitors