ChemicalBook > CAS DataBase List > VU 0360223

VU 0360223

Product Name: VU 0360223
CAS No.: 1274859-33-4
Chemical Name: VU 0360223
Synonyms: VU 0360223;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;3-fluoro-5-(2-methylbenzo[d]thiazol-5-yl)benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
CBNumber: CB22569686
Molecular Formula: C15H9FN2S
Formula Weight: 268.31
MOL File: 1274859-33-4.mol

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VU 0360223 Property

Boiling point:: 434.9±35.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 25 mM in DMSO
form: Powder
pka: 1.10±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11995
Product name: VU0360223
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11995
Product name: VU0360223
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11995
Product name: VU0360223
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 11995
Product name: VU0360223
Purity: ≥98%
Packaging: 50mg
Price: $517
Updated: 2024/03/01

TRC

Product number: V787580
Product name: VU0360223
Packaging: 5mg
Price: $65
Updated: 2021/12/16

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VU 0360223 Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC₅₀ value of 61 nM in a calcium mobilization assay and a K_i value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.

Uses

VU 0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 for use in drug addiction treatment.

IC 50

mGluR: 61 nM (IC₅₀)

storage

Room temperature

References

[1] CRAIG W. LINDSLEY. (3-Cyano-5-fluorophenyl)biaryl Negative Allosteric Modulators of mGlu5: Discovery of a New Tool Compound with Activity in the OSS Mouse Model of Addiction[J]. ACS Chemical Neuroscience, 2011, 2 8: 471-482. DOI: 10.1021/cn100099n

VU 0360223 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0360223

3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile

3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile

Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-

3-fluoro-5-(2-methylbenzo[d]thiazol-5-yl)benzonitrile

1274859-33-4