VU 0360223
- Product Name
- VU 0360223
- CAS No.
- 1274859-33-4
- Chemical Name
- VU 0360223
- Synonyms
- VU 0360223;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
- CBNumber
- CB22569686
- Molecular Formula
- C15H9FN2S
- Formula Weight
- 268.31
- MOL File
- 1274859-33-4.mol
VU 0360223 Property
- Boiling point:
- 434.9±35.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 25 mM in DMSO
- form
- Powder
- pka
- 1.10±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 11995
- Product name
- VU0360223
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 11995
- Product name
- VU0360223
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 11995
- Product name
- VU0360223
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 11995
- Product name
- VU0360223
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $517
- Updated
- 2024/03/01
- Product number
- V787580
- Product name
- VU0360223
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
VU 0360223 Chemical Properties,Usage,Production
Description
Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.
Uses
VU 0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 for use in drug addiction treatment.
storage
Room temperature