ChemicalBook > CAS DataBase List > VU 0360223

VU 0360223

Product Name
VU 0360223
CAS No.
1274859-33-4
Chemical Name
VU 0360223
Synonyms
VU 0360223;3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile;Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-;3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
CBNumber
CB22569686
Molecular Formula
C15H9FN2S
Formula Weight
268.31
MOL File
1274859-33-4.mol
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VU 0360223 Property

Boiling point:
434.9±35.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 25 mM in DMSO
form 
Powder
pka
1.10±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11995
Product name
VU0360223
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11995
Product name
VU0360223
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
11995
Product name
VU0360223
Purity
≥98%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
11995
Product name
VU0360223
Purity
≥98%
Packaging
50mg
Price
$517
Updated
2024/03/01
TRC
Product number
V787580
Product name
VU0360223
Packaging
5mg
Price
$65
Updated
2021/12/16
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VU 0360223 Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the central nervous system, signals through both ionotropic and metabotropic glutamate receptors. Of the eight metabotropic glutamate receptors (mGlus) discovered thus far, development of inhibitors to mGlu5 has been given significant attention in preclinical models of disease, including pain, anxiety, gastresophageal reflux disease, Parkinson’s associated dyskinesia, and fragile X syndrome, as well as in animal models of drug addiction. VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay. A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes. A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.

Uses

VU 0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 for use in drug addiction treatment.

storage

Room temperature

VU 0360223 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0360223 Suppliers

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  • VU 0360223
  • 3-fluoro-5-(2-methyl-1,3-benzothiazol-5-yl)benzonitrile
  • 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile
  • Benzonitrile, 3-fluoro-5-(2-methyl-5-benzothiazolyl)-
  • 1274859-33-4