ChemicalBook > CAS DataBase List > DBCO-PEG4-SE

DBCO-PEG4-SE

Product Name
DBCO-PEG4-SE
CAS No.
1427004-19-0
Chemical Name
DBCO-PEG4-SE
Synonyms
DBCO-PEG4-SE;DBCO-PEG4-NHS;DBCO-PEG4-SPA;DBCO-PEG4-NHS easer;DBCO-PEG4-NHS ester;DBCO-CONH-PEG4-NHS ester;DBCO-PEG4-succinimidyl ester;Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester;inhibit,Inhibitor,DBCO PEG4 NHS ester,DBCOPEG4NHS ester,DBCO-PEG-4-NHS ester,PROTAC Linkers;2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
CBNumber
CB22984375
Molecular Formula
C34H39N3O10
Formula Weight
649.69
MOL File
1427004-19-0.mol
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DBCO-PEG4-SE Property

Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO, DCM, DMF
pka
15.14±0.46(Predicted)
form 
gel or oil
color 
Colourless to yellow
InChI
InChI=1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)
InChIKey
RRCXYKNJTKJNTD-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O
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Safety

WGK Germany 
3
HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
764019
Product name
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
Purity
95%
Packaging
1MG
Price
$37
Updated
2023/06/20
Sigma-Aldrich
Product number
764019
Product name
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
Purity
95%
Packaging
5MG
Price
$118
Updated
2023/06/20
Sigma-Aldrich
Product number
764019
Product name
Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
Purity
95%
Packaging
50MG
Price
$510
Updated
2023/06/20
TRC
Product number
D195020
Product name
DBCO-PEG4-NHSEster
Packaging
1mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
35051
Product name
DBCO-PEG4-NHSester,95%
Purity
95%
Packaging
5MG
Price
$56
Updated
2021/12/16
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DBCO-PEG4-SE Chemical Properties,Usage,Production

Description

DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

DBCO-PEG4-SE Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG4-SE Suppliers

China 73 United Kingdom 1 United States 6 Global 80
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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View Lastest Price from DBCO-PEG4-SE manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-PEG4-NHS ester 1427004-19-0
Price
US $0.00/mg
Min. Order
50mg
Purity
>99.00%
Supply Ability
250
Release date
2024-03-20

1427004-19-0, DBCO-PEG4-SERelated Search:

Diazo Biotin-PEG3-DBCO PC DBCO-PEG3-Biotin Desthiobiotin-PEG4-DBCO 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine DBCO-amine DBCO-NHS Ester DBCO-sulfo-NHS ester DBCO-C6-NHS ester DBCO-PEG4-Acid DBCO-PEG4-biotin DBCO-PEG4-Benzylamine DBCO-PEG4-Val-Cit-PAB-PNP DBCO-PEG4-maleimide DBCO-PEG4-DBCO DBCO-PEG4-amine DBCO-SE DBCO-PEG5-NHS ester

  • DBCO-PEG4-NHS ester
  • DBCO-PEG4-SE
  • DBCO-PEG4-succinimidyl ester
  • Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester
  • DBCO-CONH-PEG4-NHS ester
  • 2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate
  • 4,7,10,13-Tetraoxa-16-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • DBCO-PEG4-SPA
  • DBCO-PEG4-NHS
  • inhibit,Inhibitor,DBCO PEG4 NHS ester,DBCOPEG4NHS ester,DBCO-PEG-4-NHS ester,PROTAC Linkers
  • DBCO-PEG4-NHS easer
  • 1427004-19-0
  • peg
  • ADC-Linkers