DBCO-NHS Ester
- Product Name
- DBCO-NHS Ester
- CAS No.
- 1353016-71-3
- Chemical Name
- DBCO-NHS Ester
- Synonyms
- N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS;DBCO-NHS ester;CAS_1353016-71-3;DBCO-NHS ester (DBCO NHS ester);Dibenzocycloctyne n-hydroxysuccinimide;4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide;2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate;11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB23146567
- Molecular Formula
- C23H18N2O5
- Formula Weight
- 402.4
- MOL File
- 1353016-71-3.mol
DBCO-NHS Ester Property
- Boiling point:
- 670.2±65.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- -0.23±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Moisture Sensitive
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D194965
- Product name
- DBCO-NHSEster
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 33411
- Product name
- DBCO-NHSester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 5MG
- Price
- $112
- Updated
- 2021/12/16
- Product number
- BP-22231
- Product name
- DBCO-NHS
- Purity
- 97%
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 33411
- Product name
- DBCO-NHSester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 25MG
- Price
- $212.8
- Updated
- 2021/12/16
- Product number
- CS-0021839
- Product name
- DBCO-NHSester
- Purity
- 99.22%
- Packaging
- 100mg
- Price
- $215
- Updated
- 2021/12/16
DBCO-NHS Ester Chemical Properties,Usage,Production
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
Uses
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
DBCO-NHS Ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-NHS Ester Suppliers
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- +1-781-999-5354 +1-00000000000
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- United States
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View Lastest Price from DBCO-NHS Ester manufacturers
- Product
- DBCO-NHS ester 1353016-71-3
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >99.00%
- Supply Ability
- 1g
- Release date
- 2024-03-20