ChemicalBook > CAS DataBase List > ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE

Product Name
ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE
CAS No.
206257-39-8
Chemical Name
ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE
Synonyms
DK659;EOS-60328;UKRORGSYN-BB BBV-080772;Ethyl4-chloro-6-bromoquinoline-3-carboxylate;ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE;ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE-4;Ethyl6-bromo-4-chloroquinoline-3-carboxylate,97%;6-Bromo-4-chloro-3-quinolinecarboxylic acid ethyl ester;6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 6-bromo-4-chloro-, ethyl ester
CBNumber
CB2342719
Molecular Formula
C12H9BrClNO2
Formula Weight
314.56
MOL File
206257-39-8.mol
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ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Property

Melting point:
100-102°
Boiling point:
378.3±37.0 °C(Predicted)
Density 
1.578
refractive index 
1.632
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.98±0.27(Predicted)
Appearance
White to off-white Solid
Water Solubility 
Immiscible in water.
InChI
InChI=1S/C12H9BrClNO2/c1-2-17-12(16)9-6-15-10-4-3-7(13)5-8(10)11(9)14/h3-6H,2H2,1H3
InChIKey
YGMLKBFPHVLHGT-UHFFFAOYSA-N
SMILES
N1C2C(=CC(Br)=CC=2)C(Cl)=C(C(OCC)=O)C=1
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HazardClass 
IRRITANT
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

AK Scientific
Product number
J57316
Product name
Ethyl6-bromo-4-chloroquinoline-3-carboxylate
Packaging
1g
Price
$62
Updated
2021/12/16
ChemScene
Product number
CS-M1122
Product name
ethyl6-bromo-4-chloroquinoline-3-carboxylate
Packaging
1g
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
045032
Product name
Ethyl 6-bromo-4-chloro-3-quinoline carboxylate
Purity
>95%
Packaging
500mg
Price
$95
Updated
2021/12/16
Apolloscientific
Product number
OR309351
Product name
6-Bromo-4-chloroquinoline-3-carboxylicacidethylester
Packaging
1g
Price
$203
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-D-00
Product name
6-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
Packaging
1g
Price
$224
Updated
2021/12/16
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ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 6-bromo-4-chloroquinoline-3-carboxylate is used as pharmaceutical intermediates

Synthesis

122794-99-4

206257-39-8

Ethyl 6-bromo-4-hydroxyquinoline-3-carboxylate (11 g, 37 mmol) was suspended in anhydrous dimethylformamide (148.6 mL) under nitrogen protection. Phosphoryl chloride (20.7 mL, 222 mmol, 6 equiv) was added slowly using a syringe. After addition, the reaction mixture was stirred vigorously for 3 hours at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water (1.5 L) and stirred continuously until the ice was completely melted. The precipitated solid product was collected by filtration, washed well with water until the washings were neutral, and subsequently dried under vacuum to constant weight. Ethyl 4-chloro-6-bromoquinoline-3-carboxylate (11.4 g, 94% yield) was finally obtained. Mass spectra (ESI) m/z (M + H) + 314.0, 316.0.

References

[1] Patent: US2012/184577, 2012, A1. Location in patent: Page/Page column 2; 3
[2] Patent: CN105859684, 2016, A. Location in patent: Paragraph 0148; 0149; 0150
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7585 - 7596
[4] RSC Advances, 2017, vol. 7, # 4, p. 2342 - 2350
[5] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 509 - 520

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Suppliers

China 110 India 3 United Kingdom 2 United States 10 Global 125
Alchem Pharmtech,Inc.
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8485655694
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United States
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Aladdin Scientific
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57505
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Synthonix Inc
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BioBlocks Incorporated
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Combi-Blocks Inc.
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SynQuest Laboratories, Inc.
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Matrix Scientific
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United States
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6632
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Ryan Scientific, Inc.
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BioBlocks, Inc.
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View Lastest Price from ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE manufacturers

Career Henan Chemical Co
Product
ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE 206257-39-8
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

206257-39-8, ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATERelated Search:

2-CYANO-5-ETHOXYCARBONYLPYRIDINE 6-BROMO-4-CHLORO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER 4,6-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER ethyl2-methylquinoline-6-carboxylate 1H-Pyrazole-3-carboxylicacid,4-cyano-,ethylester(9CI) Ethyl 4-chloro-7-methoxyquinoline- 3-carboxylate ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6-Bromo-2-naphthoic acid Ethyl 6-bromoindole-2-carboxylate 4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-Chloronicotinic acid ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE (4-Chloro-3-pyridinyl)methanol 6-BROMO-4-CHLOROQUINOLINE

  • 6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
  • UKRORGSYN-BB BBV-080772
  • 6-Bromo-4-chloro-3-quinolinecarboxylic acid ethyl ester
  • ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE-4
  • ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE
  • EOS-60328
  • 3-Quinolinecarboxylic acid, 6-bromo-4-chloro-, ethyl ester
  • Ethyl4-chloro-6-bromoquinoline-3-carboxylate
  • Ethyl6-bromo-4-chloroquinoline-3-carboxylate,97%
  • DK659
  • 206257-39-8