ChemicalBook > CAS DataBase List > 2-CHLOROPYRIMIDINE-5-BORONIC ACID

2-CHLOROPYRIMIDINE-5-BORONIC ACID

Product Name
2-CHLOROPYRIMIDINE-5-BORONIC ACID
CAS No.
1003845-06-4
Chemical Name
2-CHLOROPYRIMIDINE-5-BORONIC ACID
Synonyms
ALKYL HYDROXIMIC ACID;2-Chloropyrimidine-5-boro...;2-Chloro-pyridineyl-5-boronic;2-Chloropyrimidine-5-BoronicAci;2-CHLOROPYRIMIDINE-5-BORONIC ACID;2-CHLORO-5-PYRIMIDINEBORONIC ACID;4-Chloro-2-pyrimidine boronic acid;2-Chloro-pyridineyl-5-boronic acid;2-chloropyrimidin-5-ylboronic acid;B-(2-Chloro-5-pyrimidinyl)boronic acid
CBNumber
CB2431400
Molecular Formula
C4H4BClN2O2
Formula Weight
158.35
MOL File
1003845-06-4.mol
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2-CHLOROPYRIMIDINE-5-BORONIC ACID Property

Boiling point:
425.4±37.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.03±0.11(Predicted)
form 
Powder
color 
White
InChI
InChI=1S/C4H4BClN2O2/c6-4-7-1-3(2-8-4)5(9)10/h1-2,9-10H
InChIKey
YTCIHPTZKKWKKC-UHFFFAOYSA-N
SMILES
B(C1=CN=C(Cl)N=C1)(O)O
CAS DataBase Reference
1003845-06-4
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C428450
Product name
2-Chloropyrimidine-5-boronicacid
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
X1260
Product name
2-Chloropyrimidine-5-boronicacid
Packaging
1g
Price
$21
Updated
2021/12/16
ChemScene
Product number
CS-W004763
Product name
2-Chloro-5-pyrimidineboronicacid
Purity
99.90%
Packaging
10g
Price
$31
Updated
2021/12/16
Matrix Scientific
Product number
068746
Product name
2-Chloropyrimidine-5-boronic acid
Purity
>95%
Packaging
5g
Price
$39
Updated
2021/12/16
SynQuest Laboratories
Product number
8H60-5-03
Product name
4-Chloro-2-pyrimidine boronic acid
Packaging
1g
Price
$48
Updated
2021/12/16
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2-CHLOROPYRIMIDINE-5-BORONIC ACID Chemical Properties,Usage,Production

Uses

2-Chloropyrimidine-5-boronic acid is a pyrimidine-boronic acid compound, mainly used as a raw material for organic synthesis or a reagent for chemical reactions.

Synthesis

5419-55-6

32779-36-5

1003845-06-4

Step 1: Synthesis of 2-chloropyrimidin-5-ylboronic acid Under argon protection, 5-bromo-2-chloropyrimidine (1.0 g, 5.170 mmol) was dissolved in a solvent mixture of THF and toluene (25 mL, 4:1 v/v), and cooled to -78 °C. n-Butyllithium (1.6 M hexane solution, 3.87 mL, 5.61 mmol) was slowly added dropwise at -78 °C, and the reaction was kept at -78 °C for 4 hours after completion of the dropwise addition. After completion of the reaction, the reaction mixture was diluted with ice water, returned to room temperature and stirred for 1 hour. Subsequently, the aqueous phase was extracted with ether and the organic phase was combined. The aqueous phase was acidified to pH 2-3 with 1N hydrochloric acid and extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 2-chloropyrimidin-5-ylboronic acid (0.6 g, 73.3% yield) as a white solid. Mass spectrum (MS): 159.3 [M+H]+.

References

[1] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0508-0510
[2] Patent: WO2008/9435, 2008, A1. Location in patent: Page/Page column 189-190
[3] Patent: WO2011/84402, 2011, A1. Location in patent: Page/Page column 153

2-CHLOROPYRIMIDINE-5-BORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLOROPYRIMIDINE-5-BORONIC ACID Suppliers

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View Lastest Price from 2-CHLOROPYRIMIDINE-5-BORONIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-CHLOROPYRIMIDINE-5-BORONIC ACID 1003845-06-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloropyrimidine-5-boronic acid 1003845-06-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloropyrimidine-5-boronic acid 1003845-06-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14

1003845-06-4, 2-CHLOROPYRIMIDINE-5-BORONIC ACIDRelated Search:

2-Chlorothiophene-3-boronic acid 3-METHOXYPYRIDINE 2-Bromo-4-chloroanisole 2-Chloro-5-methoxypyrimidine 2-Chloro-5-(phenylmethoxy)-pyrimidine 4-Bromonicotinic acid 4-Bromopyridine-2-carboxylic acid 2-Amino-pyrimidine-5-boronic acid 2-ETHOXY-5-IODO-PYRIDINE 2-Chloro-5-hydroxypyrimidine 2-Bromo-5-iodopyridine 2-Bromo-6-iodopyridine 2-Chloropyrimidine-5-carbaldehyde 4-BENZYLOXY-2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 2-CHLOROPYRIMIDINE-5-BORONIC ACID 2,4-DICHLORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIMIDINE 4-TERT-BUTOXY-2-CHLOROPYRIMIDIN-5-YLBORONIC ACID

  • 2-CHLOROPYRIMIDINE-5-BORONIC ACID
  • 2-chloropyrimidin-5-ylboronic acid
  • 2-CHLORO-5-PYRIMIDINEBORONIC ACID
  • 2-Chloropyrimidine-5-boro...
  • 2-Chloro-pyridineyl-5-boronic
  • 2-Chloro-pyridineyl-5-boronic acid
  • 2-ChloropyriMidine-5-boronic acid (contains varying aMounts of anhydride)
  • BORONIC ACID,B-(2-CHLORO-5-PYRIMIDINYL)-
  • 2-CHLOROPYRIMIDINE-5-BORONIC ACID###1003845-06-4
  • ALKYL HYDROXIMIC ACID
  • 4-Chloro-2-pyrimidine boronic acid
  • 2-Chloropyrimidine-5-BoronicAci
  • B-(2-Chloro-5-pyrimidinyl)boronic acid
  • 2-Chloropyrimidine-5-boronic acid - [C0497]
  • B-(2-Chloropyrimidin-5-yl)boronic acid
  • 1003845-06-4
  • Organoborons
  • Pyrimidine
  • Heterocyclic Compounds