Vanillic acid

ChemicalBook > CAS DataBase List > Vanillic acid

Description References

Product Name: Vanillic acid
CAS No.: 121-34-6
Chemical Name: Vanillic acid
Synonyms: VA;4-HYDROXY-3-METHOXYBENZOIC ACID;vanillic;3-Methoxy-4-Hydroxybenzoic acid;Benzoic acid, 4-hydroxy-3-methoxy-;Vanillate;Magnolioside;Vanilic acid;Vanilloid;Vallinic acid
CBNumber: CB2449434
Molecular Formula: C8H8O4
Formula Weight: 168.15
MOL File: 121-34-6.mol

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Vanillic acid Property

Melting point:: 208-210 °C(lit.)
Boiling point:: 257.07°C (rough estimate)
Density: 1.3037 (rough estimate)
refractive index: 1.5090 (estimate)
FEMA: 3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID
storage temp.: Store below +30°C.
solubility: Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly）
form: Liquid
pka: pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain)
color: Clear colorless to brown, may darken during storage
Odor: at 100.00 %. dairy milky custard creamy powdery vanilla bean
Odor Type: creamy
Water Solubility: Soluble in water, alcohol and ether.
Merck: 14,9931
JECFA Number: 959
BRN: 2208364
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: WKOLLVMJNQIZCI-UHFFFAOYSA-N
LogP: 1.30
CAS DataBase Reference: 121-34-6(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6)
EPA Substance Registry System: Vanillic acid (121-34-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36
WGK Germany: 1
RTECS: YW5300000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29189090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W398802
Product name: Vanillic acid
Purity: ≥97%, FG
Packaging: 1kg
Price: $559
Updated: 2024/03/01

Sigma-Aldrich

Product number: W398802
Product name: Vanillic acid
Purity: ≥97%, FG
Packaging: 10Kg
Price: $3940
Updated: 2024/03/01

Sigma-Aldrich

Product number: 94770
Product name: Vanillic acid
Purity: purum, ≥97.0% (HPLC)
Packaging: 10g
Price: $26
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41025
Product name: Vanillic acid
Purity: for synthesis
Packaging: 50g
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: 68654
Product name: Vanillic acid
Purity: certified reference material, TraceCERT
Packaging: 50mg
Price: $128
Updated: 2024/03/01

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Vanillic acid Chemical Properties,Usage,Production

Description

Vanillic acid is a dihydroxybenzoic acid that can be used as a flavoring agent. As an oxidized form of vanillin, it is the intermediate product during the two-step bioconversion process from ferulic acid to vanillin. It exists in high amount in the root of Angelica sinenisis, which is a plant used in traditional Chinese medicine. It also exists in acal oil, argan oil as well as wine and vinegar. It can be used in the synthesis of the analeptic drug etamivan, modecainide, brovanexine, vanitiolide, and vanyldisulfamide. It can be manufactured through the oxidation of vanillin to the carboxylic acid.

References

https://en.wikipedia.org/wiki/Vanillic_acid
https://pubchem.ncbi.nlm.nih.gov/compound/Vanillic_acid#section=Top

Chemical Properties

4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste.

Chemical Properties

white odourless crystals or powder

Occurrence

Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries.

Uses

Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar.

Uses

Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.

Uses

A flavoring agent.

Definition

ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.

Preparation

Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus

Aroma threshold values

Aroma at 5.0%: weak vanilla, creamy, milky.

Taste threshold values

Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025
Organic Syntheses, Coll. Vol. 4, p. 972, 1963

General Description

Vanillic acid is one of the key aromatic volatile compounds of vanilla beans.

Biochem/physiol Actions

Taste at 100 ppm

Vanillic acid Preparation Products And Raw materials

Raw materials

Valeric acid Phosphorus trichloride 1-Pentanol butene Thionyl chloride

Preparation Products

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View Lastest Price from Vanillic acid manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Vanillic acid 121-34-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.6%
Supply Ability: 100000
Release date: 2024-04-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Vanillic Acid 121-34-6
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-24

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Vanillic acid 121-34-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 5000kg
Release date: 2024-04-19

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