2-Amino-4-chloro-6-methylpyrimidine
- Product Name
- 2-Amino-4-chloro-6-methylpyrimidine
- CAS No.
- 5600-21-5
- Chemical Name
- 2-Amino-4-chloro-6-methylpyrimidine
- Synonyms
- AM;4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE;ACLP;ProAM-N20;prepn. AM;Rhod-4™AKOS MSC-0728;Cal-630™Fura-10™AM (inhibitor)
- CBNumber
- CB2458081
- Molecular Formula
- C5H6ClN3
- Formula Weight
- 143.57
- MOL File
- 5600-21-5.mol
2-Amino-4-chloro-6-methylpyrimidine Property
- Melting point:
- 183-186 °C (lit.)
- Boiling point:
- 234.32°C (rough estimate)
- Density
- 1.2986 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- acetic acid: soluble50mg/mL, clear, colorless to faintly yellow
- pka
- 4.26±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- biological source
- rabbit
- Water Solubility
- Insoluble in water.
- BRN
- 114297
- InChI
- InChI=1S/C5H6ClN3/c1-3-2-4(6)9-5(7)8-3/h2H,1H3,(H2,7,8,9)
- InChIKey
- NPTGVVKPLWFPPX-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(C)=CC(Cl)=N1
- CAS DataBase Reference
- 5600-21-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- RTECS
- UV6329600
- HazardClass
- IRRITANT, AVOID SKIN CONTACT
- HS Code
- 29335995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 122882
- Product name
- 2-Amino-4-chloro-6-methylpyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $23.38
- Updated
- 2025/07/31
- Product number
- SAB1303888
- Product name
- ANTI-ADM (CENTER) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400 μL
- Price
- $496
- Updated
- 2025/07/31
- Product number
- 122882
- Product name
- 2-Amino-4-chloro-6-methylpyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $88.9
- Updated
- 2025/07/31
- Product number
- A1088
- Product name
- 2-Amino-4-chloro-6-methylpyrimidine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- A1088
- Product name
- 2-Amino-4-chloro-6-methylpyrimidine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $76
- Updated
- 2025/07/31
2-Amino-4-chloro-6-methylpyrimidine Chemical Properties,Usage,Production
Chemical Properties
WHITE TO LIGHT YELLOW NEEDLE-LIKE CRYST. POWDER
Uses
2-Amino-4-chloro-6-methylpyrimidine was used to study the influence of chlorine substitution in pyrimidine ring on proton donor ability of amino group in 2-aminopyrimidine.
Definition
ChEBI: An aminopyrimidine compound having its amino group at position 2 and chloro and methyl substituents at positions 4 and 6 respectively.
General Description
2-Amino-4-chloro-6-methylpyrimidine is a nitification inhibitor.
Synthesis
3977-29-5
5600-21-5
General procedure for the synthesis of 2-amino-4-chloro-6-methylpyrimidine from 2-amino-4-hydroxy-6-methylpyrimidine: 6 g of 2-amino-4-hydroxy-6-methylpyrimidine (IV) was mixed with 35 mL of freshly distilled phosphorous trichloride and the reaction was carried out by refluxing the mixture until it was homogeneous. Upon completion of the reaction, the excess phosphorous trichloride was removed under vacuum. The reaction mixture was cooled and the residue was mixed with ice water and the pH was adjusted with 25% ammonia to 8. The resulting suspension was filtered and the precipitate was washed with water. The crude product was recrystallized from 50% ethanol and dried to constant weight at constant temperature. A final 3.7 g of the target product (54% yield) was obtained with a melting point of 188°C (literature value 182-183°C [7]) and a thin-layer chromatographic Rf value of 0.79 (Expander D). Elemental analysis results: 41.74% C, 4.05% H, 29.35% N. Theoretically calculated values for the molecular formula C5H6ClN3: C 41.83%, H 4.21%, N 29.27%.
Purification Methods
Recrystallise it from EtOH. [Beilstein 24 H 84.]
References
[1] Russian Journal of General Chemistry, 2015, vol. 85, # 1, p. 79 - 87
[2] Zhurnal Obshchei Khimii, 2015, vol. 85, # 1, p. 79 - 87,9
2-Amino-4-chloro-6-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4-chloro-6-methylpyrimidine Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 2-Amino-4-chloro-6-methylpyrimidine manufacturers
- Product
- 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
- Price
- US $9.90/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-24