t-Boc-N-Amido-PEG8-propargyl
- Product Name
- t-Boc-N-Amido-PEG8-propargyl
- CAS No.
- 2183440-31-3
- Chemical Name
- t-Boc-N-Amido-PEG8-propargyl
- Synonyms
- Boc-NH-PEG8-Alkyne;Propargyl-PEG8-NHBoc;Boc-NH-PEG8-propargyl;Propargyl-PEG9-Boc Amine;t-Boc-N-Amido-PEG8-propargyl;tert-Butyl (3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-yl)carbamate;5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester;Propargyl-PEG8-NHBoc/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester
- CBNumber
- CB24849672
- Molecular Formula
- C24H45NO10
- Formula Weight
- 507.61
- MOL File
- 2183440-31-3.mol
t-Boc-N-Amido-PEG8-propargyl Property
- Boiling point:
- 565.0±50.0 °C(Predicted)
- Density
- 1.076±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 12.23±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23850
- Product name
- t-Boc-N-Amido-PEG8-propargyl
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-23850
- Product name
- t-Boc-N-Amido-PEG8-propargyl
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- BP-23850
- Product name
- t-Boc-N-Amido-PEG8-propargyl
- Purity
- 98%
- Packaging
- 500mg
- Price
- $750
- Updated
- 2021/12/16
t-Boc-N-Amido-PEG8-propargyl Chemical Properties,Usage,Production
Description
t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution.
Uses
Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-Amido-PEG8-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-Amido-PEG8-propargyl Suppliers
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
- ProdList
- 20405
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
View Lastest Price from t-Boc-N-Amido-PEG8-propargyl manufacturers
- Product
- Propargyl-PEG8-NHBoc 2183440-31-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26