ChemicalBook > CAS DataBase List > 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Product Name
7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
CAS No.
17680-55-6
Chemical Name
7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
Synonyms
B90106;CHEMBRDG-BB 4002740;7-Bromo-1,2,3,4-tetrahydroisoquinoL;7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;Isoquinoline, 7-bromo-1,2,3,4-tetrahydro-;7-BroMo-1,2,3,4-tetrahydroisoquinoline, 97%, 97%;7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE ISO 9001：2015 REACH
CBNumber
CB2692539
Molecular Formula
C9H10BrN
Formula Weight
212.09
MOL File
17680-55-6.mol
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7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Property

Melting point:
32-35°C
Boiling point:
282.9±40.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
solid
pka
9.14±0.20(Predicted)
color 
White
Water Solubility 
Insoluble in water.
InChI
InChI=1S/C9H10BrN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2
InChIKey
OYODEQFZAJVROF-UHFFFAOYSA-N
SMILES
C1C2=C(C=CC(Br)=C2)CCN1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B683600
Product name
7-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging
1g
Price
$140
Updated
2021/12/16
TRC
Product number
B683600
Product name
7-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging
250mg
Price
$95
Updated
2021/12/16
TRC
Product number
B683600
Product name
7-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging
100mg
Price
$70
Updated
2021/12/16
Ark Pharm
Product number
P000294674
Product name
7-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity
97%
Packaging
1g
Price
$38
Updated
2021/12/16
Ark Pharm
Product number
P000294674
Product name
7-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity
97%
Packaging
250mg
Price
$16
Updated
2021/12/16
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7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Chemical Properties,Usage,Production

Uses

7-Bromo-1,2,3,4-tetrahydroisoquinoline is used as a pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 4116, 1998 DOI: 10.1021/jo972184e

Synthesis

181514-35-2

17680-55-6

The general procedure for the synthesis of 7-bromo-1,2,3,4-tetrahydroisoquinoline from N-trifluoroacetyl-7-bromo-1,2,3,4-tetrahydroisoquinoline was as follows: 1-(7-bromo-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2-trifluoroacetophenone (14.3 g, 46.4 mmol) was added to a mixture of methanol (50 mL) and saturated sodium carbonate solution ( 50 mL) to a mixture of methanol (50 mL) and saturated sodium carbonate solution (50 mL). The reaction mixture was stirred at 60 °C for 1 hour. After completion of the reaction, the mixture was concentrated and the residue was extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate. After evaporation of the solvent, the crude product was purified by column chromatography to afford the light yellow solid product 7-bromo-1,2,3,4-tetrahydroisoquinoline (8.4 g, 85% yield). Mass spectrometry analysis showed m/z 213.8 (M + 1).

References

[1] Patent: WO2008/76954, 2008, A2. Location in patent: Page/Page column 51
[2] Patent: US2008/81803, 2008, A1. Location in patent: Page/Page column 34-35

7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE Preparation Products And Raw materials

Raw materials

4-Bromophenylacetonitrile Ethanol Sodium sulfate Sodium chloride Potassium carbonate Paraformaldehyde 2,6-Lutidine Tetrahydrofuran Trifluoroacetic anhydride Diethyl ether Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Sodium bicarbonate Dichloromethane Acetic acid Methanol Sodium hydroxide Magnesium sulfate Sulfuric acid

Preparation Products

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View Lastest Price from 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
7-Bromo-1,2,3,4-tetrahydroisoquinoline 17680-55-6
Price
US $1.10-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
50kg
Release date
2025-06-23
Career Henan Chemical Co
Product
7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 17680-55-6
Price
US $1.00/g
Min. Order
100g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-23

17680-55-6, 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINERelated Search:

7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-Bromo-3,4-dihydro-1H-quinolin-2-one 7-BROMO-1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOLE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 7-BroMo-1,2,3,4-tetrahydroquinolinehydrochloride 7-Bromo[1,2,4]triazolo[1,5-a]pyridine 7-BroMo-3-MethyliMidazo[1,5-a]pyridine 6-Tributylstannyl[1,2,4]triazolo[1,5-a]pyridine 7-BROMO-1H-INDOLE-3-CARBALDEHYDE 7-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine 7-bromo-4H-chromen-4-one TERT-BUTYL 7-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 8-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 8-bromo-1,2,3,4-tetrahydroisoquinoline 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 5,6,7,8-TETRAHYDROISOQUINOLINE

  • 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
  • CHEMBRDG-BB 4002740
  • B90106
  • Isoquinoline, 7-bromo-1,2,3,4-tetrahydro-
  • 7-BroMo-1,2,3,4-tetrahydroisoquinoline, 97%, 97%
  • 7-Bromo-1,2,3,4-tetrahydroisoquinoL
  • 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE ISO 9001：2015 REACH
  • 17680-55-6
  • 176800-55-6