2-AMINO-5-FLUOROPHENOL
- Product Name
- 2-AMINO-5-FLUOROPHENOL
- CAS No.
- 53981-24-1
- Chemical Name
- 2-AMINO-5-FLUOROPHENOL
- Synonyms
- EOS-61433;2-AMINO-5-FLUOROPHEN;5-Fluoro-2-aMinophenol;2-AMINO-5-FLUOROPHENOL;2-azanyl-5-fluoro-phenol;4-Fluoro-2-hydroxyaniline;2-Amino-5-fluorophenol98%;Phenol, 2-amino-5-fluoro-;2- aMino-5-difluoro phenol;2-Amino-5-fluorophenol 98%
- CBNumber
- CB2716633
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 53981-24-1.mol
2-AMINO-5-FLUOROPHENOL Property
- Melting point:
- 38°C
- Boiling point:
- 246.1±25.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO, Methanol
- pka
- 8.76±0.10(Predicted)
- form
- Solid
- color
- Dark Beige
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C6H6FNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2
- InChIKey
- IIDUNAVOCYMUFB-UHFFFAOYSA-N
- SMILES
- C1(O)=CC(F)=CC=C1N
- CAS DataBase Reference
- 53981-24-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29089990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- A2300
- Product name
- 2-Amino-5-fluorophenol
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- A2300
- Product name
- 2-Amino-5-fluorophenol
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- A609600
- Product name
- 2-Amino-5-fluorophenol
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A609600
- Product name
- 2-Amino-5-fluorophenol
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 002246
- Product name
- 2-Amino-5-fluorophenol
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
2-AMINO-5-FLUOROPHENOL Chemical Properties,Usage,Production
Chemical Properties
Dark Beige Solid
Uses
2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification.
Synthesis
446-36-6
53981-24-1
The general procedure for the synthesis of 2-amino-5-fluorophenol from 5-fluoro-2-nitrophenol is as follows: 5-fluoro-2-nitrophenol (2.50 g, 15.9 mmol, commercially available from e.g., Aldrich) was dissolved in ethanol (50 ml), and 10% palladium-carbon catalyst (980 mg) was added for the hydrogenation reaction, which lasted for 1.5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The solid residue obtained was dissolved in ether, followed by addition of an equal volume of cyclohexane. The ether was removed by vacuum distillation at room temperature to give a light gray solid product. The product was filtered and washed with cyclohexane to give 2-amino-5-fluorophenol (1.90 g, 94% yield). Elemental analysis measured values: C, 56.4; H, 4.8; N, 10.9. theoretical values (C6H6FNO): C, 56.7; H, 4.8; N, 11.0%.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[2] Patent: WO2010/94643, 2010, A1. Location in patent: Page/Page column 46
[3] Patent: US5238908, 1993, A
[4] Patent: US5393735, 1995, A
[5] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082
2-AMINO-5-FLUOROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-5-FLUOROPHENOL Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
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View Lastest Price from 2-AMINO-5-FLUOROPHENOL manufacturers
- Product
- 2-AMINO-5-FLUOROPHENOL 53981-24-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-22
- Product
- 2-AMINO-5-FLUOROPHENOL 53981-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-27