PROTAC BRD4 Degrader-5

Product Name: PROTAC BRD4 Degrader-5
CAS No.: 2409538-70-9
Chemical Name: PROTAC BRD4 Degrader-5
Synonyms: PROTAC BRD4 Degrader-5;(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CBNumber: CB27243570
Molecular Formula: C50H62ClN9O8S2
Formula Weight: 1016.67
MOL File: Mol file

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PROTAC BRD4 Degrader-5 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 145 mg/mL (142.62 mM)
pka: 13.54±0.46(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water: < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0130208
Product name: PROTACBRD4Degrader-5
Purity: 99.51%
Packaging: 10mg
Price: $2200
Updated: 2021/12/16

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PROTAC BRD4 Degrader-5 Chemical Properties,Usage,Production

Uses

PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

IC 50

BRD4

References

[1] Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312. DOI:10.1021/acschembio.0c00285

PROTAC BRD4 Degrader-5 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC BRD4 Degrader-5 Suppliers

China 6 United States 2 Global 8

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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MedChemExpress

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PROTAC BRD4 Degrader-5

(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamido}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

2409538-70-9