ChemicalBook > CAS DataBase List > L-Homoserine

L-Homoserine

Product Name
L-Homoserine
CAS No.
672-15-1
Chemical Name
L-Homoserine
Synonyms
HOMOSERINE;HSE;(S)-2-AMINO-4-HYDROXYBUTANOIC ACID;H-HOMOSER-OH;H-HSE-OH;H-HOSER-OH;H-HOMOSERINE;(2S)-2-Amino-4-hydroxybutanoic acid;RODH;SDR9C6
CBNumber
CB2854094
Molecular Formula
C4H9NO3
Formula Weight
119.12
MOL File
672-15-1.mol
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L-Homoserine Property

Melting point:
203 °C (dec.)(lit.)
alpha 
-8.5 º (c=2, H2O 22 ºC)
Boiling point:
222.38°C (rough estimate)
Density 
1.3126 (rough estimate)
refractive index 
1.4183 (estimate)
storage temp. 
Store below +30°C.
solubility 
1100g/l
pka
2.71(at 25℃)
form 
Crystalline Powder
color 
White to light yellow
optical activity
-8.825 (H2O) +18.326 (2 mol dm-3 HCl)
Water Solubility 
1100 g/L (30 ºC)
Merck 
14,4739
BRN 
1721681
InChIKey
UKAUYVFTDYCKQA-VKHMYHEASA-N
LogP
-1.289 (est)
CAS DataBase Reference
672-15-1(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25-44-35-26-28-7-4-3/9
WGK Germany 
3
F 
10
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6515
Product name
L-Homoserine
Packaging
1g
Price
$365
Updated
2024/03/01
Sigma-Aldrich
Product number
H6515
Product name
L-Homoserine
Packaging
5g
Price
$1720
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14359
Product name
L-(-)-Homoserine
Purity
for synthesis
Packaging
1g
Price
$147
Updated
2024/03/01
TCI Chemical
Product number
H1030
Product name
L-Homoserine
Purity
>98.0%(T)
Packaging
1g
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
H1030
Product name
L-Homoserine
Purity
>98.0%(T)
Packaging
5g
Price
$204
Updated
2024/03/01
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L-Homoserine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine. It is also used as an internal standard for neurotransmitter analysis and amino acids quantification.

Definition

ChEBI: L-homoserine is the L-enantiomer of homoserine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite and an Escherichia coli metabolite. It is an enantiomer of a D-homoserine. It is a tautomer of a L-homoserine zwitterion.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 3147, 1958 DOI: 10.1021/ja01545a057
The Journal of Organic Chemistry, 24, p. 1794, 1959 DOI: 10.1021/jo01093a610

General Description

L-Homoserine is a variant of serine with an additional carbon on its side chain.

Biochem/physiol Actions

L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.

Purification Methods

Likely impurities are N-chloroacetyl-L-homoserine, N-chloroacetyl-D-homoserine, L-homoserine, homoserine lactone, homoserine anhydride (formed in strong solutions of homoserine if slightly acidic). It cyclises to the lactone in strongly acidic solution. It crystallises from water by adding 9 volumes of EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2612-2616 1961, Beilstein 4 IV 3187.]

L-Homoserine Preparation Products And Raw materials

Raw materials

Preparation Products

DL-Threonine L-Lysine hydrochloride
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L-Homoserine Suppliers

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View Lastest Price from L-Homoserine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-homoserine 672-15-1
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Homoserine 672-15-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
5000kg/month
Release date
2021-10-13
Honest Joy Holdings Limited
Product
L-Homoserine 672-15-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-02-18

672-15-1, L-HomoserineRelated Search:

trans-4-Hydroxy-L-proline methyl ester hydrochloride beta-Methyl L-aspartate hydrochloride H-ASP(OTBU)-OTBU HCL Dimethyl L-aspartate hydrochloride H-CIS-HYP-OME HCL H-ASP(OET)-OET HCL L-Threonine DL-4-Amino-3-hydroxybutyric acid L(+)-allo-Threonine allo-DL-Threonine DL-GAMMA-AMINO-B-HYDROXYBUTYRIC ACIDCRYS TALLINE 2-Hydroxy-4-amino butanoic acid (S)-N-Carbobenzyloxy-4-amino-2-hydroxybutyric acid DL-Homoserine (S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID D(-)-allo-Threonine H-ASP-OBZL HCL H-ASP(OTBU)-OME HCL

  • (S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID
  • (S)-2-AMINO-4-HYDROXYBUTYRIC ACID
  • L-2-AMINO-4-HYDROXYBUTANOIC ACID
  • L-2-AMINO-4-HYDROXYBUTYRIC ACID
  • L-2-AMINO-4-HYDROXYBUTYRIC ACID HYDROCHLORIDE
  • H-L-HSE-OH
  • H-HSE-OH
  • H-HOSER-OH
  • H-HOSER-OH HCL
  • H-HOMOSER-OH
  • H-HOMOSERINE
  • HSE
  • HOMOSERINE
  • HOMOSERINE-L
  • 2-AMINO-4-HYDROXYBUTYRIC ACID
  • L-2-Amino-4-hydroxybutyricacid=H-Hser-OH
  • (S)-2-AMINO-4-HYDROXYBUTANOIC ACID
  • (S)-Homeserine
  • HOMOSERINE, (S)-2-AMINO-4-HYDROXYBUTYRIC ACID
  • L-Homoserine, (S)-2-Amino-4-hydroxybutyric acid
  • H-HOSER-OHCL
  • L-Beta-Homo-Ser
  • (2S)-2-Amino-4-hydroxybutanoic acid
  • H-HoSer-OHCl;H-HoSer-OHCl
  • L-Homoserine,97%
  • (S)-2-Amino-4-hydroxybutyric acid Hse
  • L-Homoserine 98%
  • (S)-2-Amino-4-hydroxybutyric acid Hse H-HoSer-OH
  • H-Hser-OH ,98%
  • L-Homoserine
  • NSC 206251
  • L-(-)-HOMOSERINE FOR SYNTHESIS
  • L-HoMoserine, 95+%
  • HSD17B6
  • RODH
  • SDR9C6
  • L-Homoserine, >=98%
  • L-Homoserine&gt
  • L-Homoserine USP/EP/BP
  • laevo-homoserine
  • (2S)-2-azaniumyl-4-hydroxybutanoate
  • L-Homoserine 672-15-1
  • L-Homoserine (9CI, ACI)
  • (2S)-2-amino-4-hydroxybutanoic acid (homoserine)
  • Lysine Impurity 12 (L-?Homoserine)
  • LChemicalbook-2-AMINO-4-HYDROXYBUTYRICACID
  • Carisoprodol Impurity 3 (Carisoprodol EP Impurity C)
  • L-Homoserine, 10 mM in DMSO
  • 672-15-1
  • 6-00-6
  • 627-15-1
  • HOCH2CH2CHNH2COOH
  • Amino Acid Library
  • BioChemical
  • Homo-Amino Acids
  • Metabolomics
  • Metabolic Libraries
  • Peptide Synthesis