4-(4-Aminophenoxy)-N-methylpicolinamide
- Product Name
- 4-(4-Aminophenoxy)-N-methylpicolinamide
- CAS No.
- 284462-37-9
- Chemical Name
- 4-(4-Aminophenoxy)-N-methylpicolinamide
- Synonyms
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]
- CBNumber
- CB31175425
- Molecular Formula
- C13H13N3O2
- Formula Weight
- 243.26
- MOL File
- 284462-37-9.mol
4-(4-Aminophenoxy)-N-methylpicolinamide Property
- Melting point:
- 110-112°C
- Boiling point:
- 476.8±40.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- vapor pressure
- 0.001-0.05Pa at 20-109.84℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.96±0.46(Predicted)
- color
- White to Light yellow to Light orange
- LogP
- 0.9 at 25℃ and pH7
- Surface tension
- 71.71mN/m at 883.8mg/L and 20.1℃
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A2617
- Product name
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- A2617
- Product name
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $91
- Updated
- 2024/03/01
- Product number
- A618940
- Product name
- [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- A618940
- Product name
- [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 4H48-1-9D
- Product name
- 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide
- Packaging
- 500mg
- Price
- $298
- Updated
- 2021/12/16
4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties,Usage,Production
Chemical Properties
Light-Brown Solid
Uses
Sorafenib intermediate
Synthesis
To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.
4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-Aminophenoxy)-N-methylpicolinamide manufacturers
- Product
- 4-(4-aminophenoxy)-N-methyl-picolinamide 284462-37-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-26
- Product
- 4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-27
- Product
- 4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
- Price
- US $20.00-10.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 200ton
- Release date
- 2023-03-13