ChemicalBook > CAS DataBase List > 4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide

Product Name
4-(4-Aminophenoxy)-N-methylpicolinamide
CAS No.
284462-37-9
Chemical Name
4-(4-Aminophenoxy)-N-methylpicolinamide
Synonyms
4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]
CBNumber
CB31175425
Molecular Formula
C13H13N3O2
Formula Weight
243.26
MOL File
284462-37-9.mol
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4-(4-Aminophenoxy)-N-methylpicolinamide Property

Melting point:
110-112°C
Boiling point:
476.8±40.0 °C(Predicted)
Density 
1.241±0.06 g/cm3(Predicted)
vapor pressure 
0.001-0.05Pa at 20-109.84℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
13.96±0.46(Predicted)
color 
White to Light yellow to Light orange
LogP
0.9 at 25℃ and pH7
Surface tension
71.71mN/m at 883.8mg/L and 20.1℃
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2617
Product name
4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
A2617
Product name
4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$91
Updated
2024/03/01
TRC
Product number
A618940
Product name
[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
Packaging
500mg
Price
$120
Updated
2021/12/16
TRC
Product number
A618940
Product name
[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
Packaging
1g
Price
$165
Updated
2021/12/16
AK Scientific
Product number
X4419
Product name
4-(4-Aminophenoxy)-N-methylpicolinamide
Packaging
1g
Price
$13
Updated
2021/12/16
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4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties,Usage,Production

Chemical Properties

Light-Brown Solid

Uses

Sorafenib intermediate

Synthesis

To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.

4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Aminophenoxy)-N-methylpicolinamide Suppliers

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View Lastest Price from 4-(4-Aminophenoxy)-N-methylpicolinamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-10-22
Nanjing Fred Technology Co., Ltd
Product
4-(4-aminophenoxy)-N-methyl-picolinamide 284462-37-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Hebei Yanxi Chemical Co., Ltd.
Product
4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
Price
US $20.00-10.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
200ton
Release date
2023-03-13

284462-37-9, 4-(4-Aminophenoxy)-N-methylpicolinamideRelated Search:

Sorafenib Sorafenib Impurity 35 Sorafenib Impurity 43 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Trimebutine maleate PYRIDINE-2-CARBOXAMIDE N,N-Dimethylformamide N-Methylformamide SORAFENIB N-OXIDE Sorafenib tosylate N-Methyl-4-chloropyridine-2-carboxamide 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine Sorafenib related compound 10 4-HYDROXYPHENYLFORMAMIDE Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib Related Compound 21

  • 4-(4-aMiNApheNAxy)-N-MethylpicolinaMide
  • 4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate
  • N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide
  • Sorafenib impurity A
  • Sorafenib Intermediate
  • Sorafenib Related Compound 23
  • Sorafen
  • Sorafenib Aminophenoxy Impurity
  • Sorafenib tosylate INT III
  • N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide Sorafenib Intermediates II
  • 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide
  • 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide
  • Sorafenib INT2
  • 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate
  • 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
  • 4-(4-Aminophenoxy)-N-methylpicolinamide
  • 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin
  • 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline
  • 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide
  • [4-(4-Aminophenoxy-2-pyridyl)]
  • 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide
  • 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide
  • 4-(4-Aminophenoxy)-N-methylpicolimide
  • [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide
  • 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide &gt
  • 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
  • 4-(2-N-METHYLCARBOMOYL)-4-PYRIDYLOXY)ANILINE
  • 4-(4-Aminophenoxy)-N-methylpicolinamide ISO 9001：2015 REACH
  • 4-(4-Aminophenoxy)-N-methylpicolinamide (Sorafenib Impurity)
  • SL-M2
  • 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide (IP2014)
  • 284462-37-9
  • C13H13N3O2C2H2O4
  • Sorafinib
  • Aromatics Compounds
  • Aromatics
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Sorafenib tosylate
  • 284462-37-9