4-(4-Aminophenoxy)-N-methylpicolinamide

Product Name: 4-(4-Aminophenoxy)-N-methylpicolinamide
CAS No.: 284462-37-9
Chemical Name: 4-(4-Aminophenoxy)-N-methylpicolinamide
Synonyms: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]
CBNumber: CB31175425
Molecular Formula: C13H13N3O2
Formula Weight: 243.26
MOL File: 284462-37-9.mol

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4-(4-Aminophenoxy)-N-methylpicolinamide Property

Melting point:: 110-112°C
Boiling point:: 476.8±40.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
vapor pressure: 0.001-0.05Pa at 20-109.84℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 13.96±0.46(Predicted)
form: solid
color: White to Light yellow to Light orange
LogP: 0.9 at 25℃ and pH7
Surface tension: 71.71mN/m at 883.8mg/L and 20.1℃

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2617
Product name: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: A2617
Product name: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $91
Updated: 2024/03/01

TRC

Product number: A618940
Product name: [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
Packaging: 500mg
Price: $120
Updated: 2021/12/16

TRC

Product number: A618940
Product name: [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide
Packaging: 1g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: X4419
Product name: 4-(4-Aminophenoxy)-N-methylpicolinamide
Packaging: 1g
Price: $13
Updated: 2021/12/16

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4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties,Usage,Production

Chemical Properties

Light-Brown Solid

Uses

Sorafenib intermediate

Synthesis

To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.

4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Aminophenoxy)-N-methylpicolinamide Suppliers

Americas 1 Canada 1 China 343 Europe 1 Germany 1 India 56 Japan 2 Russia 1 Switzerland 1 United Kingdom 5 United States 20 Global 432

Shandong Shenghe Pharmaceutical Technology Co. LTD

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from 4-(4-Aminophenoxy)-N-methylpicolinamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-10-22

Nanjing Fred Technology Co., Ltd

Product: 4-(4-aminophenoxy)-N-methyl-picolinamide 284462-37-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-26

Hebei Yanxi Chemical Co., Ltd.

Product: 4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9
Price: US $20.00-10.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 200ton
Release date: 2023-03-13

284462-37-9, 4-(4-Aminophenoxy)-N-methylpicolinamideRelated Search:

Sorafenib Sorafenib Impurity 35 Sorafenib Impurity 43 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Trimebutine maleate PYRIDINE-2-CARBOXAMIDE N,N-Dimethylformamide N-Methylformamide SORAFENIB N-OXIDE Sorafenib tosylate N-Methyl-4-chloropyridine-2-carboxamide 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine Sorafenib related compound 10 4-HYDROXYPHENYLFORMAMIDE Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib Related Compound 21

4-(4-aMiNApheNAxy)-N-MethylpicolinaMide

4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate

N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide

Sorafenib impurity A

Sorafenib Intermediate

Sorafenib Related Compound 23

Sorafen

Sorafenib Aminophenoxy Impurity

Sorafenib tosylate INT III

N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide Sorafenib Intermediates II

4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide

4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide

Sorafenib INT2

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

4-(4-Aminophenoxy)-N-methylpicolinamide

4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin

4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide

[4-(4-Aminophenoxy-2-pyridyl)]

4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide

4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide

4-(4-Aminophenoxy)-N-methylpicolimide

[4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide &gt

2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-

4-(2-N-METHYLCARBOMOYL)-4-PYRIDYLOXY)ANILINE

4-(4-Aminophenoxy)-N-methylpicolinamide ISO 9001：2015 REACH

4-(4-Aminophenoxy)-N-methylpicolinamide (Sorafenib Impurity)

SL-M2

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide (IP2014)

284462-37-9

C13H13N3O2C2H2O4

Sorafinib

Aromatics Compounds

Aromatics

Bases & Related Reagents

Heterocycles

Nucleotides

Sorafenib tosylate

284462-37-9