ChemicalBook > CAS DataBase List > Polyinosinic acid-polycytidylic acid

Polyinosinic acid-polycytidylic acid

Product Name
Polyinosinic acid-polycytidylic acid
CAS No.
24939-03-5
Chemical Name
Polyinosinic acid-polycytidylic acid
Synonyms
polyi:c;polyi-c;Poly-Na;poly(i+c);Poly I:Cr;nsc-120949;polycpolyi;poly(ri:rc);Polyinosinic;polyri:polyrc
CBNumber
CB3181814
Molecular Formula
C19H27N7O16P2
Formula Weight
671.41
MOL File
24939-03-5.mol
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Polyinosinic acid-polycytidylic acid Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble to 3 mg/ml in water
Stability:
Hygroscopic
InChIKey
ACEVNMQDUCOKHT-WOQDZEJINA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r|
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Safety

WGK Germany 
3
RTECS 
TR0175000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H402Harmful to aquatic life

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
4287
Product name
Poly(I:C)
Packaging
10
Price
$98
Updated
2021/12/16
Tocris
Product number
4287
Product name
Poly(I:C)
Packaging
50
Price
$410
Updated
2021/12/16
TRC
Product number
P688075
Product name
Poly(I:C)(~90%)
Packaging
50mg
Price
$65
Updated
2021/12/16
TRC
Product number
P688075
Product name
Poly(I:C)(~90%)
Packaging
250mg
Price
$85
Updated
2021/12/16
ApexBio Technology
Product number
B5551
Product name
Poly(I:C)
Packaging
10mg
Price
$97
Updated
2021/12/16
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Polyinosinic acid-polycytidylic acid Chemical Properties,Usage,Production

Uses

Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.

Definition

ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.

Biological Activity

poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923.

Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials

Raw materials

Yttrium oxide sulfate, terbium-doped Carbodiimide 5'—NUCLEOTIDE Cytidine 5’-monophosphate TAQ DNA POLYMERASE 5U/UL Creatine Microcrystalline cellulose Tributylamine Ribonucleic acid Sodium nitrite Agar Anhydrous pyridine Inosinic Acid Epichlorohydrin SULFATE STANDARD POLYNUCLEOTIDE PHOSPHORYLASE FROM BACIL Morpholine Ammonium sulfate

Preparation Products

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View Lastest Price from Polyinosinic acid-polycytidylic acid manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd
Product
Polyinosinic-polycytidylic acid sodium salt (PIC) 24939-03-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥90.0%
Supply Ability
10 tons
Release date
2024-02-06
Hebei Duling International Trade Co. LTD
Product
Polyinosinic-polycytidylic acid sodium salt 24939-03-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99.5%
Supply Ability
20tons
Release date
2023-02-21
Hebei Duling International Trade Co. LTD
Product
Polyinosinic-polycytidylic acid sodium salt 24939-03-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99.5%
Supply Ability
20tons
Release date
2023-02-21

24939-03-5, Polyinosinic acid-polycytidylic acidRelated Search:

Glycine Folic acid Ethyl 2-(Chlorosulfonyl)acetate Cytidine 5’-monophosphate L-DIHYDROOROTIC ACID Cytidine-5'-triphosphate disodium salt dihydrate Citric acid 5-Azacytidine Cytarabine Ascoric Acid N-BUTYLISOCYANIDE Cupric acetylacetonate TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide Aluminum acetylacetonate Inosinic Acid 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate

  • POLY(I) POLY(C)
  • POLYINOSINIC ACID POLYCYTIDYLIC ACID
  • POLYINOSINIC POLYCYTIDYLIC ACID
  • polyinosinic:polycytidylic acid copolymer
  • POLYCYTIDYLIC-INOSINIC ACID
  • Polyinosinic-polytidylin Acid.
  • POLYINOSINIC ACID . POLYCYTIDYLIC ACID, LYOPHILIZED
  • POLYCYTIDYLIC-INOSINIC ACID POTASSIUM
  • Polyinosinic
  • Polyinosinic Polycytidylic
  • POLYINOSINIC-POLYCYTIDILICACIDKSALT
  • Poly inosine-cytidine
  • 5’-inosinicacid,homopolymer,complexwith5’-cytidylicacidhomopolymer(1:
  • 5’-Inosinicacid,homopolymer,complexwith5’-cytidylicacidhomopolymer(1:1)
  • polyi:c
  • polyi-c
  • polyri:polyrc
  • Polycytidysic acid (Poly C)
  • Polyinosinic acid-po
  • nsc-120949
  • poly(i).poly(c)complex
  • poly(i+c)
  • poly(ri).(rc)
  • poly(ri).poly(rc)
  • poly(ri:rc)
  • polycpolyi
  • polycytidylic-polyinosinicacid
  • Polyinosinic-cytidylic acid disodiuM salt
  • Poly(I:C) (~90%)
  • Polyinosinic acid: polycytidylic acid (poly I:C)
  • Polyinosinic acid-polycytidylic acid USP/EP/BP
  • Poly I:Cr
  • Polyadenosinic acid sodium salt，Poly A
  • Poly-Na
  • Glycine Impurity 24
  • Polyinosinic-polycytidylic acid sodium salt (PIC)
  • 24939-03-5
  • C10H11N4O7PnC9H12N3O7PnC38H50
  • C10H13N4O8PC9H14N3O8P
  • C19H27N7O16P2
  • C10H13N4O8PxC9H14N3O8Px
  • Nucleosides, Nucleotides, Oligonucleotides
  • Synthetic Oligonucleotides and Related Reagents
  • Biochemicals and Reagents
  • BioChemical
  • Material