ChemicalBook > CAS DataBase List > 5-Methyl-2-thiophenecarboxylic acid
5-Methyl-2-thiophenecarboxylic acid
- Product Name
- 5-Methyl-2-thiophenecarboxylic acid
- CAS No.
- 1918-79-2
- Chemical Name
- 5-Methyl-2-thiophenecarboxylic acid
- Synonyms
- 5-METHYLTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-methyl-;AKOS B000091;TIMTEC-BB SBB004146;RARECHEM AL BE 0181;5-METHYL-2-THENOIC ACID;Rivaroxaban Impurity 51;2-Carboxy-5-methylthiophene;ethyl-2-thiophenecarboxylic acid;5-Methylthiophen-2-carboxylic acid
- CBNumber
- CB3183843
- Molecular Formula
- C6H6O2S
- Formula Weight
- 142.18
- MOL File
- 1918-79-2.mol
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5-Methyl-2-thiophenecarboxylic acid Property
- Melting point:
- 135-138 °C(lit.)
- Boiling point:
- 229.75°C (rough estimate)
- Density
- 1.365 (estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- 2-8°C(protect from light)
- form
- Liquid
- pka
- 3.71±0.10(Predicted)
- color
- Clear
- BRN
- 113857
- InChI
- InChI=1S/C6H6O2S/c1-4-2-3-5(9-4)6(7)8/h2-3H,1H3,(H,7,8)
- InChIKey
- VCNGNQLPFHVODE-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)SC(C)=CC=1
- CAS DataBase Reference
- 1918-79-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Methyl-2-thiophenecarboxylic acid (keto form)(1918-79-2)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- M84429
- Product name
- 5-Methyl-2-thiophenecarboxylic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $41.1
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- M84429
- Product name
- 5-Methyl-2-thiophenecarboxylic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $255
- Updated
- 2022/05/15
TCI Chemical
- Product number
- M1118
- Product name
- 5-Methyl-2-thiophenecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
TRC
- Product number
- B486023
- Product name
- 5-Methylthiophene-2-carboxylicAcid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK207658
- Product name
- 5-Methyl-2-thiophenecarboxylic Acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
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5-Methyl-2-thiophenecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
BEIGE CRYSTALLINE POWDER
Definition
ChEBI: 5-Methyl-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.
Synthesis Reference(s)
Tetrahedron Letters, 15, p. 2373, 1974 DOI: 10.1016/S0040-4039(01)92259-2
Synthesis
13679-74-8
1918-79-2
GENERAL PROCEDURE: The general procedure for the synthesis of 5-methyl-2-thiophenecarboxylic acid from 2-acetyl-5-methylthiophene was as follows: Oxone (2 eq.) and trifluoroacetic acid (TFA, 2 eq.) were added to a solution of 2-acetyl-5-methylthiophene (100 mg, 1 eq.) in dioxane (5 mL). The reaction mixture was heated to reflux for 10 hours and subsequently cooled to room temperature. Water (10 mL) was added and the mixture was extracted with ethyl acetate (EtOAc, 2 x 20 mL). The organic layers were combined and washed with saturated sodium bicarbonate (NaHCO3) solution. The sodium bicarbonate solution and the aqueous layer were poured onto crushed ice and acidified with 2 M hydrochloric acid (HCl), at which point a colorless solid precipitated. The precipitate was collected by filtration, dried under vacuum and purified by column chromatography (silica gel; ethyl acetate-hexane, 1:9) to give 5-methyl-2-thiophenecarboxylic acid as a white crystalline solid. Yield: 0.096 g (95% based on 2-acetyl-5-methylthiophene); melting point: 122-123 °C.
References
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3161 - 3168
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 3096
[3] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 5,29
5-Methyl-2-thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Methyl-2-thiophenecarboxylic acid manufacturers
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-15
Shanghai kingmorn biotechnology Co.,LTD.
- Product
- 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- >100KG
- Release date
- 2021-07-20
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-Methyl-2-thiophenecarboxylic acid 1918-79-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
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