3-Methylpyridine-2-carboxylic acid
- Product Name
- 3-Methylpyridine-2-carboxylic acid
- CAS No.
- 4021-07-2
- Chemical Name
- 3-Methylpyridine-2-carboxylic acid
- Synonyms
- 3-METHYLPICOLINIC ACID;Methylpicolinicacid;RARECHEM AL BO 0827;3-Methylpicoline Acid;3-METHYL-A-PICOLINIC ACID;3-Methyl-2-picolinic acid;3-Methylpicolinic acid,98%;3-METHYLPICOLINIC ACID 97%;3-METHYL-ALPHA-PICOLINIC ACID;3-METHYL-2-CARBOXYLIC ACID PYRI
- CBNumber
- CB3185953
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 4021-07-2.mol
3-Methylpyridine-2-carboxylic acid Property
- Melting point:
- 114-118 °C
- Boiling point:
- 300.6±22.0 °C(Predicted)
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 1.11±0.50(Predicted)
- form
- Crystalline Powder
- color
- White to tan
- InChI
- InChI=1S/C7H7NO2/c1-5-3-2-4-8-6(5)7(9)10/h2-4H,1H3,(H,9,10)
- InChIKey
- LMHIBYREWJHKNZ-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=CC=C1C
- CAS DataBase Reference
- 4021-07-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 512362
- Product name
- 3-Methylpyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5G
- Price
- $95
- Updated
- 2025/07/31
- Product number
- 512362
- Product name
- 3-Methylpyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1G
- Price
- $56.4
- Updated
- 2023/06/20
- Product number
- M1141
- Product name
- 3-Methylpyridine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 100mg
- Price
- $16
- Updated
- 2025/07/31
- Product number
- M1141
- Product name
- 3-Methylpyridine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- M1141
- Product name
- 3-Methylpyridine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $73
- Updated
- 2025/07/31
3-Methylpyridine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
3-Methylpyridine-2-carboxylic acid (3-MepicH) may be used as a ligand in the synthesis of the following metal complexes:
- [Cu(3-Mepic)2(4-pic)] where 4-pic=4-picoline and [Cu(3-Mepic)2]·2H2O
- [Co(3-Mepic)3]
- [Ni(3-Mepic)2(H2O)2]
- bis(3-methyl-picolinato-κ2 N,O)(1,10-phenanthroline)zinc(II) tetrahydrate
Definition
ChEBI: 3-Methylpicolinic acid is a member of pyridines and an aromatic carboxylic acid.
General Description
3-Methylpyridine-2-carboxylic acid, also known as 3-methylpicolinic acid (3-MepicH), is a 3-substituted picolinic acid. The dianion formed by reacting 3-MepicH with lithium diisopropylamide (LDA) can undergo C-alkylation with 3-chlorobenzyl chloride.
Synthesis
20970-75-6
4021-07-2
Synthesis of II-1-2:3-methylpyridine carboxylic acid 2.00 g (19 mmol) of 2-cyano-3-methylpyridine was dissolved in 90% sulfuric acid and the resulting solution was heated and stirred at 120°C for 2 hours. After completion of the reaction, the reaction solution was cooled to 20 °C to 25 °C and a solution of 4.00 g of sodium sulfite dissolved in 8 ml of water was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred at the same temperature for 1.5 hours, and then warmed up to 75°C-85°C and kept for 1.5 hours. After the reaction solution was cooled, the pH was adjusted to about 3 with sodium carbonate and extracted with chloroform. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1.38 g of solid product. The solid was purified by solvent recrystallization from a mixture of ethyl acetate-hexane to give the final pure product (54.0% yield). The melting point of the product was 115.5°-116.5°C and IR (KBr) showed characteristic absorption peaks: 3350, 1650, 1590 cm-1 .
References
[1] Tetrahedron, 2013, vol. 69, # 33, p. 6799 - 6803
[2] Patent: US5219847, 1993, A
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 5967,5969
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 7, p. 1501 - 1505
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 1, p. 498 - 509
3-Methylpyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methylpyridine-2-carboxylic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-Methylpyridine-2-carboxylic acid manufacturers
- Product
- 3-Methylpyridine-2-carboxylic acid 4021-07-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 3-Methylpicolinic Acid 4021-07-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-Methylpicolinic Acid 4021-07-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08