Avagacestat (BMS-708163)

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Avagacestat (BMS-708163)

Product Name: Avagacestat (BMS-708163)
CAS No.: 1146699-66-2
Chemical Name: Avagacestat (BMS-708163)
Synonyms: CS-262;BMS-708163;Avagacestat;BMS-708163, >=98%;BMS708163;BMS 708163;BMS-708163 (Avagacestat);Avagacestat (BMS-708163);BMS708163;BMS 708163;AVAGACESTAT;Avagacestat BMS-708163 BMS708163;(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoro
CBNumber: CB32470907
Molecular Formula: C20H17ClF4N4O4S
Formula Weight: 520.89
MOL File: 1146699-66-2.mol

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Avagacestat (BMS-708163) Property

Density: 1.488
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥177.6 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16711
Product name: Avagacestat
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16711
Product name: Avagacestat
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 16711
Product name: Avagacestat
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Tocris

Product number: 6363
Product name: Avagacestat
Purity: ≥98%(HPLC)
Packaging: 5
Price: $72
Updated: 2021/12/16

Tocris

Product number: 6363
Product name: Avagacestat
Purity: ≥98%(HPLC)
Packaging: 25
Price: $278
Updated: 2021/12/16

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Avagacestat (BMS-708163) Chemical Properties,Usage,Production

Uses

Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.

Definition

ChEBI: Avagacestat is an oxadiazole and a ring assembly.

Biological Activity

bms-708163 is a potent selective and orally bioavailable inhibitor of γ-secretase with ic50 value of 0.3nm [1].the cleavage of amyloid precusor protein app by γ-secretase causes the production of aβ40 and aβ42, which are cytotoxic and cause ad. in vitro assay shows bms-708163 inhibits the formation of aβ40 and aβ42 in h4-8sw cells. it also inhibits the human recombinant cyps in vitro with ic50 value of 20μm. notch receptor is another substrate of γ-secretase. the inhibition of notch signal pathway results in some side effects. it is shown that the activity of bms-708163 to inhibit notch is 190-fold weaker than to app. in female rats, oral administration of bms-708163 significantly reduces the production of aβ in plasma and brain at 10mg/kg and 100mg/kg. in addition, bms-708163 also reduces aβ in brain and csf in male beagle dogs [1].

target

γ-secretase

storage

Store at +4°C

References

[1] gillman kw, starrett je jr, parker mf, xie k, bronson jj, marcin lr, mcelhone ke, bergstrom cp, mate ra, williams r, meredith je jr, burton cr, barten dm, toyn jh, roberts sb, lentz ka, houston jg, zaczek r, albright cf, decicco cp, macor je, olson re. discovery and evaluation of bms-708163, a potent, selective and orally bioavailable γ-secretase inhibitor. acs med chem lett. 2010 mar 22;1(3):120-4.

Avagacestat (BMS-708163) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Avagacestat (BMS-708163) manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Avagacestat 1146699-66-2
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-27

Career Henan Chemical Co

Product: Avagacestat (BMS-708163) 1146699-66-2
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

1146699-66-2, Avagacestat (BMS-708163)Related Search:

STAT1 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol CCT 137690 Tariquidar (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Torin 1 Telaprevir CUDC-101 Brivanib alaninate AC480 (BMS-599626) Semagacestat ABT 737 DAPT RO4929097 LY2811376 MK-0752 Pentanamide

BMS708163;BMS 708163

CS-262

(2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide

BMS-708163

(R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide

BMS-708163 (Avagacestat)

Avagacestat

Avagacestat (BMS-708163)

(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoropen

(2R)-2-(N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide

(2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl]amino]-5,5,5-trifluoropentanamide BMS-708163

BMS-708163, >=98%

(2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-pentanamide

(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoro

BMS708163;BMS 708163;AVAGACESTAT

Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-

Avagacestat BMS-708163 BMS708163

(2R)-[(4-Chloro-benzenesulfonyl)-(2-fluoro-4-[1,2,4]oxadiazol-3-yl-benzyl)-amino]-5,5,5-trifluoro-pentanoic acid amide

1146699-66-2

C20H17ClF4N4O4S

Inhibitors