Bromhexine hydrochloride

Product Name: Bromhexine hydrochloride
CAS No.: 611-75-6
Chemical Name: Bromhexine hydrochloride
Synonyms: BROMHEXINE HCL;BREVISCAPINE;Bromexine Hcl;BROMOHEXINE HYDROCHLORIDE;bisolvon;Cofmesin;Hapysuol;Coughtimi;bromessina;Bisopollon
CBNumber: CB3249453
Molecular Formula: C14H21Br2ClN2
Formula Weight: 412.59
MOL File: 611-75-6.mol

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Bromhexine hydrochloride Property

Melting point:: 240-244 °C
storage temp.: Sealed in dry,Room Temperature
solubility: Very slightly soluble in water, slightly soluble in alcohol and in methylene chloride.
form: powder
color: White to Light Beige
λmax: 307nm(Decane)(lit.)
Merck: 14,1391
BRN: 4848376
InChIKey: UCDKONUHZNTQPY-UHFFFAOYSA-N
LogP: 5.081 (est)
CAS DataBase Reference: 611-75-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 2
RTECS: XS9950000
HS Code: 29215990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 51082
Product name: Bromhexine hydrochloride
Purity: analytical standard
Packaging: 100mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: 17343
Product name: Bromhexine hydrochloride
Purity: ≥98.0% (AT)
Packaging: 25g
Price: $90.5
Updated: 2024/03/01

TCI Chemical

Product number: B4054
Product name: Bromhexine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $37
Updated: 2024/03/01

Alfa Aesar

Product number: J63451
Product name: Bromhexine hydrochloride, 98+%
Packaging: 100g
Price: $114.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63451
Product name: Bromhexine hydrochloride, 98+%
Packaging: 500g
Price: $353.65
Updated: 2024/03/01

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Bromhexine hydrochloride Chemical Properties,Usage,Production

Description

Bromhexine Hydrochloride is the hydrochloride salt form of bromhexine, a secretolytic, with mucolytic activity. Upon administration, bromhexine increases lysosomal activity and enhances hydrolysis of acid mucopolysaccharide polymers in the respiratory tract. This increases the production of serous mucus in the respiratory tract, which makes the phlegm thinner and decreases mucus viscosity. This contributes to its secretomotoric effect, and allows the cilia to more easily transport the phlegm out of the lungs. This clears mucus from the respiratory tract and may aid in the treatment of respiratory disorders associated with abnormal viscid mucus, excessive mucus secretion and impaired mucus transport.

Chemical Properties

White Solid

Originator

Bisolvon,Boehringer Ingelheim,Switz.,1963

Uses

Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity.

Uses

Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Bromhexine hydrochloride belongs to the group of expectorants (mucoactive agents). The active substance has a secretolytic effect. It is used for the treatment of strong cough, e.g. triggered by a bronchitis.

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of spu um).

Manufacturing Process

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl- cyclohexylamine.
A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine, accompanied by stirring. The glacial acetic acid was decanted from the precipitate formed during the addition of the bromine solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium hydroxide and 600cc of chloroform until all of the solids went into solution. The chloroform phase was allowed to separate from the aqueous phase. The chloroform phase was decanted, evaporated to dryness and the residue was dissolved in absolute ether. The resulting solution was found to be a solution of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon introducing hydrogen chloride into this solution, the hydrochloride of N-(2- amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had a melting point of 232°-235°C (decomposition).

Therapeutic Function

Expectorant; Mucolytic

General Description

Bromhexine hydrochloride is a bronchial mucolytic.

Bromhexine hydrochloride Preparation Products And Raw materials

Raw materials

Methyl anthranilate 2,4-Dibromo-6-methylaniline N-Methylcyclohexylamine o-Toluidine Potassium borohydride

Preparation Products

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Bromhexine hydrochloride Suppliers

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View Lastest Price from Bromhexine hydrochloride manufacturers

Sinoway Industrial co., ltd.

Product: Bromhexine hydrochloride 611-75-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-10-28

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Bromhexine hydrochloride 611-75-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei Saisier Technology Co., LTD

Product: Bromhexine hydrochloride 611-75-6
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-24

611-75-6, Bromhexine hydrochlorideRelated Search:

Tris(hydroxymethyl)aminomethane N,N-Dimethylcyclohexylamine Aminoacetonitrile hydrochloride Cyclohexylamine hydrochloride 6-Aminocaproic acid ALTRENOGEST AMINOGUANIDINE HYDROCHLORIDE Topotecan hydrochloride D-Glucosamine hydrochloride BROMOHEXINE Dicyclohexylamine Glycine 1-AdaMantanethylaMine Cyclohexylamine 3-Aminophenol Valganciclovir hydrochloride Bromhexine-d3 HCl Metoclopramide hydrochloride

2-AMINO-3,5-DIBROMO-N-CYCLOHEXYL-N-METHYLBENZY-LAMINE HYDROCHLORIDE

n-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine hydrochloride

2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-benzenemethanaminmonohydrochlo

2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylaminehydrochloride

2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-benzylaminhydrochloride

bisolvon

bisolvonhydrochloride

bromessina

bromhexinechloride

n-(2-amino-3,5-dibromobenzyl)-n-methyl-cyclohexylammoniumchloride

LABOTEST-BB LT00244811

BROMHEXINE HCL

BROMHEXINE HYDROCHLORIDE

BROMOHEXINE HYDROCHLORIDE

n-cyclohexyl-n-methyl-(2-amino-3,5-dibromobenzyl)ammoniumchloride

toluene-alpha,2-diamine,3,5-dibromo-n(supalpha)-cyclohexyl-n-(supalpha)-meth

Bromhexine HCL BP98

BromhexineHclBromhexineHclBp/Ep

Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride

N-(2-Amino-3,5-Dibromobenzyl)-N-Cyclohexyl-Methylamine Hydrochloride

BREVISCAPINE

BROMHEXIN HYDROCHLORIDE

Bromohexine hydrochloride, 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride, N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride

Bisopollon

Cofmesin

Coughtimi

Hapysuol

BroMhexine HydrochIoride

yansuanxiuyijin

1-bromohexane hydrochloride

BroMhexine hydrochloride BP2005 API

BroMhexine Hydrocholride

2,4-DibroMo-6-((cyclohexyl(Methyl)aMino)Methyl)aniline hydrochloride

BenzeneMethanaMine,2-aMino-3,5-dibroMo-N-cyclohexyl-N-Methyl-, hydrochloride (1:1)

Hydrochloric acid and broMine have new

2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-benzenemethanamine,hydrochloride (1:1)

LABOTEST-BB

Hydrochloric acid, bromine has a new

Bromhexine hydrochloride >=98.0% (AT)

18652-93-2Bromhexine

Bromhexine Hydrochloride Impurity

Bromhexine for system suitability

Bromexhin Chlorhydrate

Benzenemethanamine,2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, hydrochloride

N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexanamine hydrochloride

Bromhexine hydrochloride CRS

Bromhexine Hydrochloride &gt

Bromhexine for system suitability CRS

Bromhexine hydrochloride USP/EP/BP

Bromexine Hcl

Bromhexine Hydrochloride / Bromhexine hcl /Bromhexine

2-AMINO-3,5-DIBROMO-N-CYCLOHEXYL-N-

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Bromhexinhydrochlorid

BROMHEXINE HYDROCLORIDE