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2'-O-(2-Methoxyethyl)cytidine

Product Name
2'-O-(2-Methoxyethyl)cytidine
CAS No.
223777-16-0
Chemical Name
2'-O-(2-Methoxyethyl)cytidine
Synonyms
2'-MOE-C;2'-MOE-rC;2'-O-MOE-rC;2'-O-MOE-Cr;2'-MOE-Cytidine;2'-O-MOE Cytidine;2'-O-MOE Cytidine;2'-O-(2-mthoxyethyl)Cytidine;2'-O-(2-Methoxyethyl)cytidine;2'-O-(2-Methoxyethyl)cytidine
CBNumber
CB32510559
Molecular Formula
C12H19N3O6
Formula Weight
301.3
MOL File
223777-16-0.mol
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2'-O-(2-Methoxyethyl)cytidine Property

Boiling point:
535.3±60.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO : 250 mg/mL (829.74 mM)
pka
13.36±0.70(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1
InChIKey
YKOGMMXZKKVMBT-QCNRFFRDSA-N
SMILES
OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M262570
Product name
2''-O-(2-Methoxyethyl)cytidine
Packaging
25mg
Price
$1760
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0002420
Product name
2'-O-(2-METHOXYETHYL)CYTIDINE
Purity
95.00%
Packaging
0.25G
Price
$786
Updated
2021/12/16
Biosynth Carbosynth
Product number
NM16315
Product name
2'-O-(2-Methoxyethyl)cytidine
Packaging
500mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
1312AB
Product name
2'-O-(2-Methoxyethyl)-cytidine
Packaging
1g
Price
$320
Updated
2021/12/16
AK Scientific
Product number
1312AB
Product name
2'-O-(2-Methoxyethyl)-cytidine
Packaging
2g
Price
$455
Updated
2021/12/16
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2'-O-(2-Methoxyethyl)cytidine Chemical Properties,Usage,Production

Description

2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products.

Uses

A cytidine derivative as building blocks for cross-linking oligonucleotides.

Synthesis

2'-O-(2-Methoxyethyl)uridine could be converted into the corresponding cytidine derivative (2'-O-(2-Methoxyethyl)cytidine) by the 4-nitrophenylation[1]. 2'-O-(2-Methoxyethyl)uridine, l-methylpyrrolidine, chlorotrimethylsilane and dry acetonitrile were stirred together at rt. After 1 h, the reaction mixture was cooled to 0 ℃, and trifluoroacetic anhydride was added dropwise over 5 min. After a further period of 30 rain at 0 ℃, 4-nitrophenol was added to the stirred reactants which were maintained at 0 °C. After 3 h, the products were poured into saturated aqueous sodium hydrogen carbonate, and the resulting mixture was extracted with dichloromethane. The combined organic layers were dried, and evaporated under reduced pressure. Concentrated aqueous ammonia was added to a stirred solution of the residue in dioxane, contained in a sealed flask that was then heated at 55°C for 24 h. The resulting yellow solution was concentrated under reduced pressure and the residue was evaporated with absolute ethanol. The products were fractionated by short column chromatography on silica gel and were evaporated under reduced pressure to give 2'-O-(2-Methoxyethyl)cytidine as an off-white solid.

References

[1] Urtzi et al. "Conversion of uridine into 2′-O-(2-methoxyethyl)uridine and 2′-O-(2-methoxyethyl)cytidine." Tetrahedron (1999).

2'-O-(2-Methoxyethyl)cytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-(2-Methoxyethyl)cytidine Suppliers

Canada 1 China 86 India 2 United Kingdom 1 United States 7 Global 97
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from 2'-O-(2-Methoxyethyl)cytidine manufacturers

Yunbio Tech Co.,Ltd.
Product
2'-O-(2-Methoxyethyl)cytidine 223777-16-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200KG per month
Release date
2023-03-04
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-O-(2-Methoxyethyl)cytidine 223777-16-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27
SHANGHAI NOVRIBO BIOTECH
Product
2'-O-(2-methoxyethyl)-Cytidine；2’-MOE-C 223777-16-0
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21

223777-16-0, 2'-O-(2-Methoxyethyl)cytidineRelated Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

  • 2'-O-(2-Methoxyethyl)cytidine
  • 2'-O-MOE Cytidine
  • 4-AMINO-1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE
  • 2'-O-(2-Methoxyethyl)-cytidine, >97%
  • 4-AMINO-1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE
  • 4-amino-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one
  • Cytidine, 2'-O-(2-methoxyethyl)-
  • 2'-O-MOE-rC
  • 2'-MOE-Cytidine
  • 2'-O-MOE-Cr
  • 2'-MOE-rC
  • 2'-MOE-C
  • 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one
  • 2'-O-(2-mthoxyethyl)Cytidine
  • 2'-O-(2-Methoxyethyl)cytidine
  • 2'-O-MOE Cytidine
  • 223777-16-0
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides