2'-O-(2-Methoxyethyl)-5-methyluridine
- Product Name
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- CAS No.
- 163759-49-7
- Chemical Name
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- Synonyms
- MOE-mrU;2'-O-MOE-Tr;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;5-Me-2'-O-MOE U;5-Me-2'-O-MOE-Ur;2'-O-MOE-5-Me-rU;2'-O-MOE-5-Me-rU;5-Me-2'-O-MOE-Me-U
- CBNumber
- CB82510024
- Molecular Formula
- C13H20N2O7
- Formula Weight
- 316.31
- MOL File
- 163759-49-7.mol
2'-O-(2-Methoxyethyl)-5-methyluridine Property
- Melting point:
- 115.5-116.5 °C
- Density
- 1.41
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
- form
- Solid
- pka
- 9.55±0.10(Predicted)
- color
- Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
- InChIKey
- NEVQCHBUJFYGQO-DNRKLUKYSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M304495
- Product name
- 2''-O-(2-Methoxyethyl)-5-methyl-uridine
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- M304495
- Product name
- 2''-O-(2-Methoxyethyl)-5-methyl-uridine
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- NM57538
- Product name
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- NM57538
- Product name
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- NM57538
- Product name
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Usage,Production
Uses
2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.
Application
2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.
Synthesis
2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.
2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-O-(2-Methoxyethyl)-5-methyluridine manufacturers
- Product
- 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200KG per month
- Release date
- 2023-03-04
- Product
- 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg per month
- Release date
- 2022-12-27
- Product
- 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26