2'-O-(2-Methoxyethyl)-5-methyluridine

Product Name: 2'-O-(2-Methoxyethyl)-5-methyluridine
CAS No.: 163759-49-7
Chemical Name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Synonyms: MOE-mrU;2'-O-MOE-Tr;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;5-Me-2'-O-MOE U;5-Me-2'-O-MOE-Ur;2'-O-MOE-5-Me-rU;2'-O-MOE-5-Me-rU;5-Me-2'-O-MOE-Me-U
CBNumber: CB82510024
Molecular Formula: C13H20N2O7
Formula Weight: 316.31
MOL File: 163759-49-7.mol

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2'-O-(2-Methoxyethyl)-5-methyluridine Property

Melting point:: 115.5-116.5 °C
Density: 1.41
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
pka: 9.55±0.10(Predicted)
color: Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
InChIKey: NEVQCHBUJFYGQO-DNRKLUKYSA-N
SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M304495
Product name: 2''-O-(2-Methoxyethyl)-5-methyl-uridine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

TRC

Product number: M304495
Product name: 2''-O-(2-Methoxyethyl)-5-methyl-uridine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 1g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 250mg
Price: $85
Updated: 2021/12/16

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2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Usage,Production

Uses

2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.

Application

2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.

Synthesis

2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-(2-Methoxyethyl)-5-methyluridine Suppliers

China 104 India 2 United Kingdom 1 United States 7 Global 114

Jiangsu Synthgene Biotechnology Co.,Ltd.

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View Lastest Price from 2'-O-(2-Methoxyethyl)-5-methyluridine manufacturers

Yunbio Tech Co.,Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200KG per month
Release date: 2023-03-04

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

Henan Aochuang Chemical Co.,Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

163759-49-7, 2'-O-(2-Methoxyethyl)-5-methyluridineRelated Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97%

1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE

5-Me-2'-O-MOE U

Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl-

5-Me-2'-O-MOE Uridine

2'-O-(2-Methoxyethy)-5-methyluridine

2'-O-MOE-5-Methyluridin

2'-O-MOE-Tr

2'-O-Methoxyethyl-thyminde

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

2'-MOE-5-Me-Uridine

2’-MOE-5-Methyluridine

5-Me-2'-O-MOE-Ur

2'-O-MOE-5-Me-rU

MOE-mrU

2'-MOE-5-Me-rU

2'-O-Methoxyethyl-5-methyluridine

2'-O-MOE-5-Me-rU

2'-O-(2-Methoxyethyl)-5-methyluridine

2’-O-(2-Methoxyethy)-5-methyl uridine

5-Me-2'-O-MOE U

2'-MOE-5-Methyluridine

2'-O-Methoxyethyl-thymine

5-Me-2'-O-MOE-Me-U

2'-O-MOE-Tr

2'-o-Methoxyethyl-5-methyluridine

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

163759-49-7

Modified（deoxy）nucleoside

Nucleosides-2'-O-MOE Nucleosides