2'-O-(2-Methoxyethyl)-5-methyluridine

Product Name: 2'-O-(2-Methoxyethyl)-5-methyluridine
CAS No.: 163759-49-7
Chemical Name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Synonyms: MOE-mrU;2'-O-MOE-Tr;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;5-Me-2'-O-MOE U;5-Me-2'-O-MOE-Ur;2'-O-MOE-5-Me-rU;2'-O-MOE-5-Me-rU;5-Me-2'-O-MOE-Me-U
CBNumber: CB82510024
Molecular Formula: C13H20N2O7
Formula Weight: 316.31
MOL File: 163759-49-7.mol

More

Less

2'-O-(2-Methoxyethyl)-5-methyluridine Property

Melting point:: 115.5-116.5 °C
Density: 1.41
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
pka: 9.55±0.10(Predicted)
color: Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
InChIKey: NEVQCHBUJFYGQO-DNRKLUKYSA-N
SMILES: OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M304495
Product name: 2''-O-(2-Methoxyethyl)-5-methyl-uridine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

TRC

Product number: M304495
Product name: 2''-O-(2-Methoxyethyl)-5-methyl-uridine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 1g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM57538
Product name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Packaging: 250mg
Price: $85
Updated: 2021/12/16

More

Less

2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Usage,Production

Uses

2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.

Application

2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.

Synthesis

2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2'-O-(2-Methoxyethyl)-5-methyluridine Suppliers

China 102 India 2 United Kingdom 1 United States 7 Global 112

Jiangsu Synthgene Biotechnology Co.,Ltd.

Tel: 18136497538
Email: znf@syngenebio.com
Country: China
ProdList: 901
Advantage: 58

Allbiosyn Biotechnology Co.,LTD

Tel: 18666985712
Email: info@allbiosyn.com
Country: China
ProdList: 285
Advantage: 58

Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.

Tel: 0371-65325800 13700860222
Email: haifeng.zhang@pannacean.com
Country: China
ProdList: 637
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-0553-5842013-801-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 295
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

Okeanos Tech Co,. Ltd.

Tel: 010-62651721 18610486005
Fax: 01062651521-808
Email: minghui.yu@okeanos.com.cn
Country: China
ProdList: 498
Advantage: 60

More

Less

View Lastest Price from 2'-O-(2-Methoxyethyl)-5-methyluridine manufacturers

Yunbio Tech Co.,Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200KG per month
Release date: 2023-03-04

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

Henan Aochuang Chemical Co.,Ltd.

Product: 2'-O-(2-Methoxyethyl)-5-methyluridine 163759-49-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

163759-49-7, 2'-O-(2-Methoxyethyl)-5-methyluridineRelated Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97%

1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE

5-Me-2'-O-MOE U

Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl-

5-Me-2'-O-MOE Uridine

2'-O-(2-Methoxyethy)-5-methyluridine

2'-O-MOE-5-Methyluridin

2'-O-MOE-Tr

2'-O-Methoxyethyl-thyminde

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

2'-MOE-5-Me-Uridine

2’-MOE-5-Methyluridine

5-Me-2'-O-MOE-Ur

2'-O-MOE-5-Me-rU

MOE-mrU

2'-MOE-5-Me-rU

2'-O-Methoxyethyl-5-methyluridine

2'-O-MOE-5-Me-rU

2'-O-(2-Methoxyethyl)-5-methyluridine

2’-O-(2-Methoxyethy)-5-methyl uridine

5-Me-2'-O-MOE U

2'-MOE-5-Methyluridine

2'-O-Methoxyethyl-thymine

5-Me-2'-O-MOE-Me-U

2'-O-MOE-Tr

2'-o-Methoxyethyl-5-methyluridine

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

163759-49-7

Modified（deoxy）nucleoside

Nucleosides-2'-O-MOE Nucleosides