2'-O-(2-Methoxyethyl)cytidine
- Product Name
- 2'-O-(2-Methoxyethyl)cytidine
- CAS No.
- 223777-16-0
- Chemical Name
- 2'-O-(2-Methoxyethyl)cytidine
- Synonyms
- 2'-MOE-C;2'-MOE-rC;2'-O-MOE-rC;2'-O-MOE-Cr;2'-MOE-Cytidine;2'-O-MOE Cytidine;2'-O-MOE Cytidine;2'-O-(2-mthoxyethyl)Cytidine;2'-O-(2-Methoxyethyl)cytidine;2'-O-(2-Methoxyethyl)cytidine
- CBNumber
- CB32510559
- Molecular Formula
- C12H19N3O6
- Formula Weight
- 301.3
- MOL File
- 223777-16-0.mol
2'-O-(2-Methoxyethyl)cytidine Property
- Boiling point:
- 535.3±60.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 250 mg/mL (829.74 mM)
- pka
- 13.36±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1
- InChIKey
- YKOGMMXZKKVMBT-QCNRFFRDSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M262570
- Product name
- 2''-O-(2-Methoxyethyl)cytidine
- Packaging
- 25mg
- Price
- $1760
- Updated
- 2021/12/16
- Product number
- NM16315
- Product name
- 2'-O-(2-Methoxyethyl)cytidine
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 1312AB
- Product name
- 2'-O-(2-Methoxyethyl)-cytidine
- Packaging
- 1g
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 1312AB
- Product name
- 2'-O-(2-Methoxyethyl)-cytidine
- Packaging
- 2g
- Price
- $455
- Updated
- 2021/12/16
- Product number
- NUC0002420
- Product name
- 2'-O-(2-METHOXYETHYL)CYTIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.68
- Updated
- 2021/12/16
2'-O-(2-Methoxyethyl)cytidine Chemical Properties,Usage,Production
Description
2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products.
Uses
A cytidine derivative as building blocks for cross-linking oligonucleotides.
Synthesis
2'-O-(2-Methoxyethyl)uridine could be converted into the corresponding cytidine derivative (2'-O-(2-Methoxyethyl)cytidine) by the 4-nitrophenylation[1]. 2'-O-(2-Methoxyethyl)uridine, l-methylpyrrolidine, chlorotrimethylsilane and dry acetonitrile were stirred together at rt. After 1 h, the reaction mixture was cooled to 0 ℃, and trifluoroacetic anhydride was added dropwise over 5 min. After a further period of 30 rain at 0 ℃, 4-nitrophenol was added to the stirred reactants which were maintained at 0 °C. After 3 h, the products were poured into saturated aqueous sodium hydrogen carbonate, and the resulting mixture was extracted with dichloromethane. The combined organic layers were dried, and evaporated under reduced pressure. Concentrated aqueous ammonia was added to a stirred solution of the residue in dioxane, contained in a sealed flask that was then heated at 55°C for 24 h. The resulting yellow solution was concentrated under reduced pressure and the residue was evaporated with absolute ethanol. The products were fractionated by short column chromatography on silica gel and were evaporated under reduced pressure to give 2'-O-(2-Methoxyethyl)cytidine as an off-white solid.
References
[1] Urtzi et al. "Conversion of uridine into 2′-O-(2-methoxyethyl)uridine and 2′-O-(2-methoxyethyl)cytidine." Tetrahedron (1999).
2'-O-(2-Methoxyethyl)cytidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2'-O-(2-Methoxyethyl)cytidine manufacturers
- Product
- 2'-O-(2-Methoxyethyl)cytidine 223777-16-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200KG per month
- Release date
- 2023-03-04
- Product
- 2'-O-(2-Methoxyethyl)cytidine 223777-16-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg per month
- Release date
- 2022-12-27
- Product
- 2'-O-(2-methoxyethyl)-Cytidine；2’-MOE-C 223777-16-0
- Price
- US $100.00/kg
- Min. Order
- 0.009999999776482582kg
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2023-03-21