ChemicalBook > CAS DataBase List > 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Use

Product Name: 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
CAS No.: 1016636-76-2
Chemical Name: 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
Synonyms: 6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one;6-broMo-2-chloro-8-cyclopentyl-5-;6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one;PALBOCI;PALBOCICLIB-PB3;Palbociclib-015;Palbociclib nuclear;Pabucilib impurity 8;Palbociclib Impurity I;Palbociclib Intermediate 3
CBNumber: CB32554175
Molecular Formula: C13H13BrClN3O
Formula Weight: 342.62
MOL File: 1016636-76-2.mol

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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Property

Melting point:: 190-192°C
Boiling point:: 468.4±45.0 °C(Predicted)
Density: 1.645±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: -0.61±0.20(Predicted)
color: White
InChI: InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
InChIKey: HJQCAEDIUJXGCQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B682195
Product name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 096533
Product name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: J52040
Product name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 096533
Product name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

AK Scientific

Product number: J52040
Product name: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Packaging: 10g
Price: $42
Updated: 2021/12/16

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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Usage,Production

Use

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

Description

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a pharmaceutical intermediate that can be used to synthesize Palbociclib, an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 for the treatment of breast cancer.

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

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View Lastest Price from 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1016636-76-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-09-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100kg
Release date: 2021-11-03

Henan Aochuang Chemical Co.,Ltd.

Product: 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1016636-76-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

1016636-76-2, 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-oneRelated Search:

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Palbociclib Impurity N Palbociclib Impurity D 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib-012 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Ezetimibe (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-on

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-broMo-2-chloro-8-cyclopentyl-5-Methyl-

Palbociclib-015

6-bromo-2-chloro-8-cyclopentyl-5-methylpyridino[2,3-d]pyrimidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-

6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one

PALBOCICLIB-PB3

6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(For Palbociclib)

6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one

PALBOCI

6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

Palbociclib Intermediate 3

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1016636-76-2)

Palbociclib Impurity I

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2

-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one ISO 9001：2015 REACH

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidin-7-(8H)-one

6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)

6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 6-

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidi...

Palbociclib nuclear

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(9H)-one

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidine-7-(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-

Pabucilib impurity 8

1016636-76-26-Bromo-2-chloro-8-cyclopentyl-5-methyl-pyrido[2,3-D]pyrimidin-7(8H)-one

1016636-76-2

1016636-76-3

2174002-19-8

Palbociclib

PD 0332991

Anticancer

1016636-76-2