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ChemicalBook > CAS DataBase List > 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

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Product Name
6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
CAS No.
1016636-76-2
Chemical Name
6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
Synonyms
6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one;6-broMo-2-chloro-8-cyclopentyl-5-;6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one;PALBOCI;PALBOCICLIB-PB3;Palbociclib-015;Palbociclib nuclear;Pabucilib impurity 8;Palbociclib Impurity I;Palbociclib Intermediate 3
CBNumber
CB32554175
Molecular Formula
C13H13BrClN3O
Formula Weight
342.62
MOL File
1016636-76-2.mol
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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Property

Melting point:
190-192°C
Boiling point:
468.4±45.0 °C(Predicted)
Density 
1.645±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
-0.61±0.20(Predicted)
color 
White
InChI
InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
InChIKey
HJQCAEDIUJXGCQ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B682195
Product name
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Packaging
100mg
Price
$80
Updated
2021/12/16
Matrix Scientific
Product number
096533
Product name
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
AK Scientific
Product number
J52040
Product name
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
096533
Product name
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
AK Scientific
Product number
J52040
Product name
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Packaging
10g
Price
$42
Updated
2021/12/16
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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Usage,Production

Use

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

Description

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a pharmaceutical intermediate that can be used to synthesize Palbociclib, an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 for the treatment of breast cancer.

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

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View Lastest Price from 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
100kg
Release date
2021-11-03
hebei hongtan Biotechnology Co., Ltd
Product
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-05-17
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Palbociclib Impurity 8 1016636-76-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-13

1016636-76-2, 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-oneRelated Search:

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Palbociclib Impurity N Palbociclib Impurity D 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib-012 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Ezetimibe (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-on
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
  • Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-broMo-2-chloro-8-cyclopentyl-5-Methyl-
  • Palbociclib-015
  • 6-bromo-2-chloro-8-cyclopentyl-5-methylpyridino[2,3-d]pyrimidin-7(8H)-one
  • 6-broMo-2-chloro-8-cyclopentyl-5-
  • 6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one
  • PALBOCICLIB-PB3
  • 6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(For Palbociclib)
  • 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
  • PALBOCI
  • 6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
  • Palbociclib Intermediate 3
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1016636-76-2)
  • Palbociclib Impurity I
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2
  • -broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one ISO 9001：2015 REACH
  • 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidin-7-(8H)-one
  • 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)
  • 6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 6-
  • 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidi...
  • Palbociclib nuclear
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(9H)-one
  • 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidine-7-(8H)-one
  • 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-
  • Pabucilib impurity 8
  • 1016636-76-2
  • 1016636-76-3
  • 2174002-19-8
  • Palbociclib
  • PD 0332991
  • Anticancer
  • 1016636-76-2