WH-4-023

Product Name: WH-4-023
CAS No.: 837422-57-8
Chemical Name: WH-4-023
Synonyms: KIN112;CS-1827;WH-4-023;WH-4-024;KIN001-112;WH-4-023, >=98%;)(2-((4-(4-methyL;WH-4-023【SML1334】;WH-4-023 (KIN-112;WH-4-023 USP/EP/BP
CBNumber: CB32710784
Molecular Formula: C32H36N6O4
Formula Weight: 568.67
MOL File: 837422-57-8.mol

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WH-4-023 Property

Boiling point:: 743.2±70.0 °C(Predicted)
Density: 1.247±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (60 mg/ml)
form: powder
pka: 7.89±0.42(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1334
Product name: WH-4-023
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1334
Product name: WH-4-023
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $564
Updated: 2023/01/07

Cayman Chemical

Product number: 9002067
Product name: WH-4-023
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 9002067
Product name: WH-4-023
Purity: ≥98%
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 9002067
Product name: WH-4-023
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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WH-4-023 Chemical Properties,Usage,Production

Description

WH-4-23 (837422-57-8) is a potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively.1,2 Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively.3 May be used along with PD-325901 and CHIR-99021 to support self-renewal of na?ve human embryonic stem cells.4

Uses

WH-4-023 is a potent and selective dual lymphocyte-specific kinase (Lck) inhibitor.

Definition

ChEBI: N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester is a member of piperazines.

Biochem/physiol Actions

WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).

storage

Store at -20°C

References

[1] MATTHEW W. MARTIN. Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity[J]. Journal of Medicinal Chemistry, 2006, 49 16: 4981-4991. DOI:10.1021/jm060435i
[2] JAMIE A. MOROCO. A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region[J]. Chemical Biology & Drug Design, 2014, 86 2: 144-155. DOI:10.1111/cbdd.12473
[3] KRISTOPHER CLARK. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012: 16986-16991. DOI:10.1073/pnas.1215450109
[4] Systemic identification of culture conditions for introduction and maintenance of naïve human pluripotency

WH-4-023 Preparation Products And Raw materials

Raw materials

Preparation Products

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WH-4-023 Suppliers

China 129 India 1 The Netherlands 1 United Kingdom 1 United States 16 Global 148

Target molecule Corp.

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View Lastest Price from WH-4-023 manufacturers

Career Henan Chemical Co

Product: 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE 837422-57-8
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 96%
Supply Ability: 10kg
Release date: 2019-09-04

837422-57-8, WH-4-023Related Search:

GW441756 ZM 306416 hydrochloride 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- JX401 JAK3 INHIBITOR II JAK3 INHIBITOR I 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Y27632 (hydrochloride) Saracatinib SB590885 PD 0325901 IM-12 Olaparib

WH-4-023

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE

Carbamic acid, N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-, 2,6-dimethylphenyl ester

KIN001-112

KIN112

2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate WH-4-023

WH-4-023 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE

WH-4-023, >=98%

WH-4-023, 837422-57-8

2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-

2,6-Dimethylphenyl N-[2,4-bis(methyloxy)phenyl][2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate

DUAL LCK/SRC INHIBITOR

CS-1827

WH-4-024

2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate

DUAL LCK/SRC INHIBITOR;KIN001-112; KIN112

)(2-((4-(4-methyL

)amino)pyrimidin-4-yL

2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate

WH-4-023 USP/EP/BP

WH-4-023, 10 mM in DMSO

WH-4-023【SML1334】

WH-4-023 (KIN-112

WH-4-023/ 837422-57-8/98%

837422-57-8

Inhibitors

API