DBCO-amine

Product Name: DBCO-amine
CAS No.: 1255942-06-3
Chemical Name: DBCO-amine
Synonyms: DBCO-NH2;DBCO-amine;DBCO-CH2CH2NH2;DBCO-(CH2)2-NH2;ADIBO-CH2CH2NH2·TFA;DBCO-(CH2)3-NH2.TFA;DBCO-(CH2)2-NH2.TFA;Dibenzocyclooctyne-amine;DBCO-Amine (DBCO amine);Azadibenzocylooctyne-amine
CBNumber: CB32730210
Molecular Formula: C18H16N2O
Formula Weight: 276.33
MOL File: 1255942-06-3.mol

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DBCO-amine Property

Melting point:: 86-96°C
Boiling point:: 549.9±50.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: -20°C
pka: 8.81±0.10(Predicted)
form: Solid
color: Yellow to Orange
InChI: InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
InChIKey: PQFQVUMDOWUGMK-CHMOPDDRSA-N
SMILES: C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCN

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Safety

WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 761540
Product name: Dibenzocyclooctyne-amine
Purity: for Copper-free Click Chemistry
Packaging: 10mg
Price: $64.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 761540
Product name: Dibenzocyclooctyne-amine
Purity: for Copper-free Click Chemistry
Packaging: 100mg
Price: $488
Updated: 2024/03/01

Alfa Aesar

Product number: J65637
Product name: Azadibenzocyclooctyne-amine
Packaging: 25mg
Price: $178
Updated: 2024/03/01

Alfa Aesar

Product number: J65637
Product name: Azadibenzocyclooctyne-amine
Packaging: 100mg
Price: $473
Updated: 2024/03/01

TRC

Product number: D195013
Product name: DBCO-Amine
Packaging: 50mg
Price: $900
Updated: 2021/12/16

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DBCO-amine Chemical Properties,Usage,Production

Description

DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.

Uses

DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.

Properties and Applications

DBCO-amine is an aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition (SPAAC, also known as “copper-free click chemistry”). The DBCO moiety reacts selectively with azides via SPAAC to form stable triazole linkages. The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents. It recommends dimethylsulfoxide (DMSO), N, N’-dimethylformamide (DMF), or N, N’-dimethylacetamide (DMAC) as solvents for this product. DBCO-amine is relatively insensitive to bases and can be used in the presence of aqueous bases. This product is acid-sensitive. It should not be subjected to pH <5 during reaction or workup. The product should always be stored at -20°C when not in use.

DBCO-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-amine Suppliers

China 139 Europe 1 France 1 Germany 3 India 3 Japan 1 United States 16 Global 164

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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9i LLC

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Email: MWan@NiNeiLab.com
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Aladdin Scientific

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Aceschem Inc.

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Aston Chemical

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BroadPharm. Inc.

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MedChemExpress

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Combi-Blocks Inc.

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Riedel-de Haen AG

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View Lastest Price from DBCO-amine manufacturers

Henan Fengda Chemical Co., Ltd

Product: DBCO-amine 1255942-06-3
Price: US $6.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-amine 1255942-06-3
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-03-20

1255942-06-3, DBCO-amineRelated Search:

DBCO-PEG4-maleimide BDP FL DBCO 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine DBCO-NHS Ester DBCO-sulfo-NHS ester DBCO-PEG4-SE DBCO-C6-NHS ester DBCO-PEG4-biotin DBCO-PEG4-amine DIBENZAZEPINE Dacarbazine DBCO-maleimide DBCO-PEG4-Acid DBCO-PEG3-amine DBCO-PEG5-CH2CH2COOH DBCO-SS-Maleimide DBCO-PEG23-amine DBCO-PEG8-Benzylamine

Dibenzocyclooctyne-aMine for Copper-free Click CheMistry

ADIBO-CH2CH2NH2·TFA

Azadibenzocyclooctyne-(CH2)2-amine TFA

DBCO-amine

DBCO-NH2

Dibenzocyclooctyne-amine

DBCO-(CH2)2-NH2.TFA

DBCO-(CH2)3-NH2.TFA

DBCO-(CH2)2-NH2

Azadibenzocyclooctyne-amine

Dibenzocyclooctyne-amine (This product is unavailable in the U.S.)

1-Propanone, 3-amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-

3-amino-1-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}propan-1-one

DBCO-Amine (DBCO amine)

Azadibenzocylooctyne-amine

3-Amino-1-[(5-aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-1-propanone

3-Amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1-propanone

1-Propanone, 3-amino-1-(11,12-didehydrodibenz[b,?f]azocin-5(6H)-yl)- （DBCO-NH2）

ADC,Antibody-drug conjugates linkers,inhibit,non-cleavable,ADC Linkers,Inhibitor,DBCOamine,antibody-drug,DBCO-amine,conjugates,DBCO amine

DBCO-CH2CH2NH2

3-amino-1-{10-azatricyclo[10.4.0.04,9]hexadeca-1(16),4(5),6,8,12(13),14-hexaen-2-yn-10-yl}propan-1-one

3-amino-1-(2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4,6,8,13,15-hexaen-10-yn-2-yl)propan-1-one

1255942-06-3

DBCO