ChemicalBook > CAS DataBase List > 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Product Name
4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
CAS No.
138163-07-2
Chemical Name
4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Synonyms
RARECHEM AL BF 0487;METHYL 1-CBZ-ISONIPECOTATE;Methyl 1-Cbz-piperidine-4...;N-CBZ-4-CARBOXYMETHOXY-PIPERIDINE;Cbz-isonipecotic acid methyl ester;N-Cbz-isonipecotic acid methyl ester;Methyl 1-Cbz-piperidine-4-carboxylate;1-(N-CBZ-PIPERIDIN-4-YLOXY)ACETIC ACID;1-CBZ-4-piperidinecarboxylicacimethylester;1-Benzyl 4-methyl 1,4-piperidinedicarboxylate
CBNumber
CB3286065
Molecular Formula
C15H19NO4
Formula Weight
277.32
MOL File
138163-07-2.mol
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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Property

Boiling point:
390.4±42.0 °C(Predicted)
Density 
1.187±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-2.34±0.40(Predicted)
Appearance
Colorless to light yellow Solid-liquid mixture
InChI
InChI=1S/C15H19NO4/c1-19-14(17)13-7-9-16(10-8-13)15(18)20-11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
InChIKey
SLMXUTJFULFSMQ-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CCC(C(OC)=O)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B288693
Product name
1-Benzyl4-Methylpiperidine-1,4-dicarboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
B105
Product name
Methyl1-Cbz-Isonipecotate
Packaging
25g
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-02
Product name
N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity
95%
Packaging
5G
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-02
Product name
N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity
95%
Packaging
25g
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-02
Product name
N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity
95%
Packaging
100g
Price
$250
Updated
2021/12/16
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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Chemical Properties,Usage,Production

Synthesis

67-56-1

10314-98-4

138163-07-2

General procedure for the synthesis of methyl N-Cbz-4-piperidinecarboxylate from methanol and 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid: concentrated sulfuric acid (two drops, using a Pasteur pipette) was slowly added dropwise (two drops) to a methanolic solution of 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid (540 mg, 2.05 mmol), and the reaction mixture was heated and refluxed for 5 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated under reduced pressure. To the concentrated residue was added saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl N-Cbz-4-piperidinecarboxylate (532 mg, 1.92 mmol, 93% yield) as a colorless oil.1H-NMR (400 MHz, CDCl3) δ: 1.57-1.73 (2H, m), 1.82-1.96 (2H, m), 2.43-2.55 ( 1H, m), 2.85-2.97 (2H, m), 3.69 (3H, s), 4.02-4.17 (2H, m), 5.12 (2H, s), 7.29-7.40 (5H, m).IR (neat, cm-1): 1732, 1696, 1450, 1433, 1223, 1192, 1175, 1040.

References

[1] Patent: EP2009006, 2008, A1. Location in patent: Page/Page column 81-82
[2] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 31
[3] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 60
[4] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 57
[5] Patent: US2010/234340, 2010, A1. Location in patent: Page/Page column 41

4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Suppliers

China 97 France 1 Germany 2 India 1 United Kingdom 4 United States 16 Global 121
Interchim S.A.
Tel
--
Fax
--
Email
interchim@interchim.com
Country
France
ProdList
6302
Advantage
76
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View Lastest Price from 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER manufacturers

Career Henan Chemical Co
Product
4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 138163-07-2
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-05

138163-07-2, 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTERRelated Search:

1-Cbz-4-Piperidone tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate N-Boc-Piperidine-4-carboxylic acid methyl ester Ethyl N-Boc-piperidine-4-carboxylate ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Ethyl 1-methylnipecotate Ethyl 1-methyl-4-piperidinecarboxylate Methyl N-methyl piperidine-4-carboxylate Ethyl 1-methylpipecolinate METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Ethyl 1-benzylpiperidine-4-carboxylate Benzyl 2-methylpiperidine-1,2-dicarboxylate 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Methyl 1-methylpiperidine-3-carboxylate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 3-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

  • 1-(N-CBZ-PIPERIDIN-4-YLOXY)ACETIC ACID
  • 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • RARECHEM AL BF 0487
  • N-CBZ-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
  • N-CBZ-4-CARBOXYMETHOXY-PIPERIDINE
  • METHYL 1-CBZ-ISONIPECOTATE
  • N-Cbz-isonipecotic acid methyl ester
  • 1-CBZ-4-piperidinecarboxylicacimethylester
  • Methyl 1-Cbz-piperidine-4...
  • 1,4-Piperidinedicarboxylic acid, 4-methyl 1-(phenylmethyl) ester
  • Cbz-isonipecotic acid methyl ester
  • Methyl 1-Cbz-piperidine-4-carboxylate
  • 1-Benzyl 4-Methyl piperidine-1,4-dicarboxylate
  • Piperidine derivative CAS NO.138163-07-2 Methyl-N-CBZ-piperidine-4-carboxylate
  • Piperidine derivative Methyl-N-CBZ-piperidine-4-carboxylate
  • O1-benzyl O4-methyl piperidine-1,4-dicarboxylate
  • 4-Methyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate
  • 1-Benzyl 4-methyl 1,4-piperidinedicarboxylate
  • 1-N-Cbz-piperidin-4-yloxy)acetic acid, CAS 138163-07-2
  • 138163-07-2
  • pharmacetical