4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

Product Name: 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
CAS No.: 138163-07-2
Chemical Name: 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Synonyms: RARECHEM AL BF 0487;METHYL 1-CBZ-ISONIPECOTATE;Methyl 1-Cbz-piperidine-4...;N-CBZ-4-CARBOXYMETHOXY-PIPERIDINE;Cbz-isonipecotic acid methyl ester;N-Cbz-isonipecotic acid methyl ester;Methyl 1-Cbz-piperidine-4-carboxylate;1-(N-CBZ-PIPERIDIN-4-YLOXY)ACETIC ACID;1-CBZ-4-piperidinecarboxylicacimethylester;1-Benzyl 4-methyl 1,4-piperidinedicarboxylate
CBNumber: CB3286065
Molecular Formula: C15H19NO4
Formula Weight: 277.32
MOL File: 138163-07-2.mol

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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Property

Boiling point:: 390.4±42.0 °C(Predicted)
Density: 1.187±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -2.34±0.40(Predicted)
Appearance: Colorless to light yellow Solid-liquid mixture
InChI: InChI=1S/C15H19NO4/c1-19-14(17)13-7-9-16(10-8-13)15(18)20-11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3
InChIKey: SLMXUTJFULFSMQ-UHFFFAOYSA-N
SMILES: N1(C(OCC2=CC=CC=C2)=O)CCC(C(OC)=O)CC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B288693
Product name: 1-Benzyl4-Methylpiperidine-1,4-dicarboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: B105
Product name: Methyl1-Cbz-Isonipecotate
Packaging: 25g
Price: $40
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-02
Product name: N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity: 95%
Packaging: 5G
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-02
Product name: N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity: 95%
Packaging: 25g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-02
Product name: N-Cbz-4-Piperidinecarboxylic acid methyl ester
Purity: 95%
Packaging: 100g
Price: $250
Updated: 2021/12/16

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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Chemical Properties,Usage,Production

Synthesis

67-56-1

10314-98-4

138163-07-2

General procedure for the synthesis of methyl N-Cbz-4-piperidinecarboxylate from methanol and 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid: concentrated sulfuric acid (two drops, using a Pasteur pipette) was slowly added dropwise (two drops) to a methanolic solution of 1-(benzyloxycarbonyl)piperidine-4-carboxylic acid (540 mg, 2.05 mmol), and the reaction mixture was heated and refluxed for 5 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated under reduced pressure. To the concentrated residue was added saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl N-Cbz-4-piperidinecarboxylate (532 mg, 1.92 mmol, 93% yield) as a colorless oil.1H-NMR (400 MHz, CDCl3) δ: 1.57-1.73 (2H, m), 1.82-1.96 (2H, m), 2.43-2.55 ( 1H, m), 2.85-2.97 (2H, m), 3.69 (3H, s), 4.02-4.17 (2H, m), 5.12 (2H, s), 7.29-7.40 (5H, m).IR (neat, cm-1): 1732, 1696, 1450, 1433, 1223, 1192, 1175, 1040.

References

[1] Patent: EP2009006, 2008, A1. Location in patent: Page/Page column 81-82
[2] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 31
[3] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 60
[4] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 57
[5] Patent: US2010/234340, 2010, A1. Location in patent: Page/Page column 41

4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Suppliers

China 97 France 1 Germany 2 India 1 United Kingdom 4 United States 16 Global 121

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View Lastest Price from 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 138163-07-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

138163-07-2, 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTERRelated Search:

1-Cbz-4-Piperidone tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate N-Boc-Piperidine-4-carboxylic acid methyl ester Ethyl N-Boc-piperidine-4-carboxylate ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Ethyl 1-methylnipecotate Ethyl 1-methyl-4-piperidinecarboxylate Methyl N-methyl piperidine-4-carboxylate Ethyl 1-methylpipecolinate METHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE Ethyl 1-benzylpiperidine-4-carboxylate Benzyl 2-methylpiperidine-1,2-dicarboxylate 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Methyl 1-methylpiperidine-3-carboxylate 1-BENZYL 4-ETHYL PIPERIDINE-1,4-DICARBOXYLATE 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 3-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

1-(N-CBZ-PIPERIDIN-4-YLOXY)ACETIC ACID

4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

RARECHEM AL BF 0487

N-CBZ-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

N-CBZ-4-CARBOXYMETHOXY-PIPERIDINE

METHYL 1-CBZ-ISONIPECOTATE

N-Cbz-isonipecotic acid methyl ester

1-CBZ-4-piperidinecarboxylicacimethylester

Methyl 1-Cbz-piperidine-4...

1,4-Piperidinedicarboxylic acid, 4-methyl 1-(phenylmethyl) ester

Cbz-isonipecotic acid methyl ester

Methyl 1-Cbz-piperidine-4-carboxylate

1-Benzyl 4-Methyl piperidine-1,4-dicarboxylate

Piperidine derivative CAS NO.138163-07-2 Methyl-N-CBZ-piperidine-4-carboxylate

Piperidine derivative Methyl-N-CBZ-piperidine-4-carboxylate

O1-benzyl O4-methyl piperidine-1,4-dicarboxylate

4-Methyl 1-(phenylmethyl) 1,4-piperidinedicarboxylate

1-Benzyl 4-methyl 1,4-piperidinedicarboxylate

1-N-Cbz-piperidin-4-yloxy)acetic acid, CAS 138163-07-2

138163-07-2

pharmacetical