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DIHYDROMETHYSTICIN

Product Name
DIHYDROMETHYSTICIN
CAS No.
19902-91-1
Chemical Name
DIHYDROMETHYSTICIN
Synonyms
dhm;Nsc112159;PseudoMethysticin;DIHYDROMETHYSTICIN;DIHYDROMETHYLSTICIN;Dihydromethysticin-RM;7,8-dihydromethysticin;7,8-DIHYDROMETHYLSTICIN;Methysticin, 7,8-dihydro-;Dihydroanesthetic capsicin
CBNumber
CB3307966
Molecular Formula
C15H16O5
Formula Weight
276.28
MOL File
19902-91-1.mol
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DIHYDROMETHYSTICIN Property

storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
Boiling point:
476.1±45.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
Melting point:
117-118 °C
form 
Solid
color 
White to Off-White
BRN 
91699
Stability:
Hygroscopic
InChIKey
RSIWXFIBHXYNFM-NSHDSACASA-N
LogP
1.810 (est)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
52007
Product name
(+)-Dihydromethysticin
Purity
analytical standard
Packaging
5mg
Price
$539
Updated
2022/05/15
Cayman Chemical
Product number
27644
Product name
Dihydromethysticin
Packaging
5mg
Price
$238
Updated
2024/03/01
TRC
Product number
B203530
Product name
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
Packaging
10mg
Price
$375
Updated
2021/12/16
ChemScene
Product number
CS-4245
Product name
Dihydromethysticin
Packaging
10mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HBL0000233
Product name
(+)-DIHYDROMETHYSTICIN
Purity
95.00%
Packaging
5MG
Price
$933.26
Updated
2021/12/16
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DIHYDROMETHYSTICIN Chemical Properties,Usage,Production

Description

Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.

Uses

(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.

Definition

ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether.

DIHYDROMETHYSTICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROMETHYSTICIN Suppliers

China 111 Germany 1 United Kingdom 3 United States 13 USA 1 Global 129
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View Lastest Price from DIHYDROMETHYSTICIN manufacturers

Career Henan Chemical Co
Product
DIHYDROMETHYSTICIN 19902-91-1
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-10

19902-91-1, DIHYDROMETHYSTICINRelated Search:

DIHYDROKAVAIN YANGONIN FLAVOKAWAINC FLAVOKAVAIN A(P) L-KAWAIN Kavain METHYSTICIN DIHYDROMETHYSTICIN DIHYDROMETHYSTICIN(P) Dihydrokawain DIHYDROMETHYSTICIN 5,6-DIHYDRO-2H-PYRAN-2-ONE 5,6-DIHYDRO-4-METHOXY-2H-PYRAN 3-BENZO[1,3]DIOXOL-5-YL-PROPAN-1-OL 1-PHENYL-HEX-5-EN-3-OL 5,6-DIHYDRO-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE DIHYDROMETHYSTICIN SNAP-N-SHOOT 0.1mg/mL(P) PARASORBICACID

  • 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s)
  • 6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on
  • 7,8-dihydromethysticin
  • dhm
  • DIHYDROMETHYLSTICIN
  • 7,8-DIHYDROMETHYLSTICIN
  • 5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one
  • 6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)phenethyl]-, (S)-
  • 2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (S)-
  • Methysticin, 7,8-dihydro-
  • Nsc112159
  • PseudoMethysticin
  • Dihydromethysticin ((+)-Dihydromethysticin)
  • (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-Methoxy-2H-pyran-2-one
  • DIHYDROMETHYSTICIN
  • 2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (6S)-
  • Dihydromethysticin,Inhibitor,inhibit,CYPs,Cytochrome P450
  • (S)-6-(2-(Benzo[d][1,3]dioxol-5-yl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
  • Dihydroanesthetic capsicin
  • Dihydromethysticin-RM
  • 19902-91-1
  • Coumarins