ChemicalBook > CAS DataBase List > t-Boc-N-Amido-PEG3-propargyl

t-Boc-N-Amido-PEG3-propargyl

Product Name
t-Boc-N-Amido-PEG3-propargyl
CAS No.
1333880-60-6
Chemical Name
t-Boc-N-Amido-PEG3-propargyl
Synonyms
Propargyl-PEG3-NHBoc;Boc-NH-PEG3-propargyl;Boc-N-Amido-PEG3-Alkyne;Propargyl-PEG4-Boc Amine;t-Boc-N-Amido-PEG3-propargyl;tert-butyl N-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethyl]carbamate;tert-Butyl (2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate;5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,?1-?dimethylethyl ester;Propargyl-PEG3-NHBoc/5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,1-dimethylethyl ester
CBNumber
CB33364014
Molecular Formula
C14H25NO5
Formula Weight
287.35
MOL File
1333880-60-6.mol
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t-Boc-N-Amido-PEG3-propargyl Property

Boiling point:
386.4±32.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
solubility 
Soluble in DMSO, DCM, DMF
pka
12.22±0.46(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23500
Product name
t-Boc-N-Amido-PEG3-propargyl
Purity
98%
Packaging
500mg
Price
$620
Updated
2021/12/16
Aaron Chemicals
Product number
AR019F00
Product name
t-Boc-N-Amido-PEG3-propargyl
Purity
95%
Packaging
100mg
Price
$99
Updated
2021/12/16
Acrotein
Product number
B-1344
Product name
Propargyl-PEG3-NHBoc
Purity
97%
Packaging
0.25g
Price
$183.3
Updated
2021/12/16
Aaron Chemicals
Product number
AR019F00
Product name
t-Boc-N-Amido-PEG3-propargyl
Purity
95%
Packaging
250mg
Price
$191
Updated
2021/12/16
Aaron Chemicals
Product number
AR019F00
Product name
t-Boc-N-Amido-PEG3-propargyl
Purity
95%
Packaging
1g
Price
$545
Updated
2021/12/16
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t-Boc-N-Amido-PEG3-propargyl Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG3-propargyl enables formation of triazole linkage with azide-bearing compound via copper catalyzed Click Chemistry. Under mild acidic conditions, t-Boc group can be removed to yield the free amine.

Uses

Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG3-propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

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t-Boc-N-Amido-PEG3-propargyl Suppliers

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View Lastest Price from t-Boc-N-Amido-PEG3-propargyl manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG3-NHBoc 1333880-60-6
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-26

1333880-60-6, t-Boc-N-Amido-PEG3-propargylRelated Search:

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  • tert-Butyl (2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate
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  • Propargyl-PEG3-NHBoc/5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,1-dimethylethyl ester
  • tert-butyl N-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethyl]carbamate
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  • SiChem