ChemicalBook > CAS DataBase List > 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

Product Name: 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
CAS No.: 222978-03-2
Chemical Name: 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
Synonyms: 4-CYANO-3-FLUOROBENZYL BROMIDE;4-Cyano-3-fluorobenzylbromide98%;4-Cyano-3-fluorobenzyl bromide 98%;4-(BROMOMETHYL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(bromomethyl)-2-fluoro-;4-(Bromomethyl)-2-fluorobenzonitrile 98%;4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile
CBNumber: CB3339303
Molecular Formula: C8H5BrFN
Formula Weight: 214.03
MOL File: 222978-03-2.mol

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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Property

Melting point:: 44-45 °C
Boiling point:: 275.6±30.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Methanol (Slightly)
form: Solid
color: Off-White
Sensitive: Lachrymatory

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Safety

Hazard Codes: C,Xn
Risk Statements: 20/21/22
Safety Statements: 36/37
Hazard Note: Corrosive/Lachrymatory
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B697158
Product name: 4-(Bromomethyl)-2-fluorobenzonitrile
Packaging: 1g
Price: $50
Updated: 2021/12/16

TRC

Product number: B697158
Product name: 4-(Bromomethyl)-2-fluorobenzonitrile
Packaging: 10g
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC37300
Product name: 4-Cyano-3-fluorobenzyl bromide
Packaging: 500mg
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: PC5928
Product name: 4-(Bromomethyl)-2-fluorobenzonitrile
Purity: 98%
Packaging: 5g
Price: $124
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC37300
Product name: 4-Cyano-3-fluorobenzyl bromide
Packaging: 1g
Price: $125
Updated: 2021/12/16

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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Chemical Properties,Usage,Production

Uses

4-(Bromomethyl)-2-fluorobenzonitrile is a useful building block for the preparation and optimization of the highly selective GLUT1 inhibitor, BAY-876.

Synthesis

85070-67-3

222978-03-2

2-Fluoro-4-methylbenzonitrile (10 g, 74.07 mmol) was used as a raw material, which was dissolved in 200 mL of chloroform, 1 g of benzoyl peroxide (BPO) was added, and stirred until completely dissolved. Subsequently, N-bromosuccinimide (NBS, 19.77 g, 11.11 mmol) was added in batches and the reaction mixture was refluxed for 12 hours. After completion of the reaction, it was cooled to room temperature and washed three times with saturated aqueous sodium bicarbonate solution, then three times with appropriate amount of water and finally three times with saturated brine. The solvent was removed by evaporation under reduced pressure and purified by column chromatography to give the light yellow liquid product 4-cyano-3-fluorobenzyl bromide (14.00 g) in 88.79% yield.

References

[1] Patent: CN106810552, 2017, A. Location in patent: Paragraph 0068; 0070; 0071
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[3] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Journal of the American Chemical Society, 2001, vol. 123, # 9, p. 2107 - 2108

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE 222978-03-2
Price: US $101.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-28

222978-03-2, 4-(BROMOMETHYL)-2-FLUOROBENZONITRILERelated Search:

6-CHLORO-1-METHYLURACIL Trelagliptin Impurity 24 2-(Bromomethyl)-6-fluorobenzonitrile 4-Fluoro-2-methylbenzonitrile N-METHYLBARBITURIC ACID Trelagliptin Impurity Y Trelagliptin Impurity 20 2-Bromo-5-fluorotoluene alpha-Cyclopentylmandelic acid Trelagliptin Impurity 18 6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 2-(DibroMoMethyl)-4-fluorobenzonitrile Trelagliptin Impurity 19 Trelagliptin Impurity 17 Dimethyl sulfate 4-(BROMOMETHYL)-3-FLUOROBENZONITRILE 4-Cyanobenzyl bromide 2-Fluoro-4-methylbenzonitrile

4-Cyano-3-fluorobenzyl bromide 98%

4-Cyano-3-fluorobenzylbromide98%

4-CYANO-3-FLUOROBENZYL BROMIDE

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

4-(Bromomethyl)-2-fluorobenzonitrile 98%

4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile

Benzonitrile, 4-(bromomethyl)-2-fluoro-

222978-03-2

Fluorine series