ChemicalBook > CAS DataBase List > 1-Benzofuran-5-carbaldehyde

1-Benzofuran-5-carbaldehyde

Product Name: 1-Benzofuran-5-carbaldehyde
CAS No.: 10035-16-2
Chemical Name: 1-Benzofuran-5-carbaldehyde
Synonyms: 5-Formylbenzofuran;5-FORMYLBENZO(B)FURAN;5-Formyl-1-benzofuran;Benzofurancarbaldehyde;5-Benzofurancarbaldehyde;5-FORMYLBENZO[BETA]FURAN;Benzofuran-5-carbaldehyde;5-Benzofurancarboxaldehyde;1-BENZOFURAN-5-CARBALDEHYDE;Benzofuran-5-carboxaldehyde
CBNumber: CB3437146
Molecular Formula: C9H6O2
Formula Weight: 146.14
MOL File: 10035-16-2.mol

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1-Benzofuran-5-carbaldehyde Property

Melting point:: 50.5
Boiling point:: 70-74°C 0,15mm
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: low melting solid
color: Light yellow crystalline
InChI: InChI=1S/C9H6O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-6H
InChIKey: LLLBDLDNTMMZHL-UHFFFAOYSA-N
SMILES: O1C2=CC=C(C=O)C=C2C=C1
CAS DataBase Reference: 10035-16-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B203670
Product name: 1-Benzofuran-5-carbaldehyde
Packaging: 1g
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB10743
Product name: 1-Benzofuran-5-carbaldehyde
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB10743
Product name: 1-Benzofuran-5-carbaldehyde
Packaging: 1g
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR10877
Product name: Benzo[b]furan-5-carboxaldehyde
Purity: 97%
Packaging: 100mg
Price: $21
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB10743
Product name: 1-Benzofuran-5-carbaldehyde
Packaging: 250mg
Price: $80
Updated: 2021/12/16

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1-Benzofuran-5-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

1-Benzofuran-5-carbaldehyde is a building block used as a reactant in the synthetic preparation of benzofuranyl oxadiazoles as inhibitors of glycogen synthase kinase-3β with good brain permeability. It is also used in the synthesis of pyrroloquinolone PDE5 inhibitors used for clinical studies on erectile dysfunction.

Synthesis

55745-70-5

10035-16-2

General procedure for the synthesis of benzofuran-5-carbaldehyde from 2,3-dihydrobenzofuran-5-carbaldehyde: N-bromosuccinimide (NBS, 0.656 g, 3.69 mmol) and azobisisobutyronitrile (AIBN, 8.10 mg, 49.2 μmol) were added to a solution of chlorobenzene (7.3 mL) at room temperature and under argon protection to 2,3-dihydrobenzofuran-5-carbaldehyde (0.364 g, 2.46 mmol) in a solution of chlorobenzene (7.3 mL). The reaction mixture was stirred at 80 °C for 1 h before being cooled to room temperature and diluted with ethyl acetate (EtOAc). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 3:97) to afford benzofuran-5-carbaldehyde (0.268 g, 1.84 mmol, 75% yield) as a colorless oil. Its 1H-NMR (CDCl3, 400 MHz) data were as follows: δ 6.82 (d, J = 2.0 Hz, 1H, furan-H), 7.54 (d, J = 8.8 Hz, 1H, Ar-H), 7.65 (d, J = 2.0 Hz, 1H, furan-H), 7.79 (d, J = 8.8 Hz, 1H, Ar-H), 8.07 (s 1H, Ar-H), 9.99 (s, 1H, -CHO). The spectral data of the obtained compounds are in agreement with literature reports (van Otterlo et al., 2005).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 20, p. 6270 - 6286
[2] Phytochemistry, 2013, vol. 96, p. 132 - 147
[3] Patent: US2014/309427, 2014, A1. Location in patent: Paragraph 0074; 0075; 0076; 0077
[4] Patent: WO2018/64135, 2018, A1. Location in patent: Paragraph 0174-0177

1-Benzofuran-5-carbaldehyde Preparation Products And Raw materials

Raw materials

Sulfur Sodium hydride p-Toluenesulfonic acid Acetonitrile Nitrogen tert-Butyllithium N-Bromosuccinimide Ethanol N,N-Dimethylformamide Sodium chloride Bromoacetaldehyde diethyl acetal Potassium carbonate Phosphorus oxitrichloride 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Carbon tetrachloride 2,3-Dihydrobenzofuran Polyphosphoric acid Diethyl ether Benzene Ammonium chloride 4-Bromophenol Ethyl acetate Hydrochloric acid Sodium bicarbonate Sodium hydroxide Magnesium sulfate PETROLEUM ETHER n-Butyllithium

Preparation Products

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View Lastest Price from 1-Benzofuran-5-carbaldehyde manufacturers

LY Global chemicals co.,ltd .

Product: 1-Benzofuran-5-carbaldehyde 10035-16-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-19

Career Henan Chemical Co

Product: 1-Benzofuran-5-carbaldehyde 10035-16-2
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-23

10035-16-2, 1-Benzofuran-5-carbaldehydeRelated Search:

4-Dimethylaminobenzaldehyde Benzaldehyde 4-Nitrobenzaldehyde Benzofuran 4-Hydroxybenzaldehyde o-Phthalaldehyde Furfural p-Anisaldehyde PONGAMOL VISNAGIN Iprocrolol KARANJIN sodium benzaldehyde-o-sulfonate KHELLIN Furobufen KHELLINONE 2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE 2,2-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE

1-BENZOFURAN-5-CARBALDEHYDE

5-FORMYLBENZO[BETA]FURAN

5-FORMYLBENZO(B)FURAN

5-Formylbenzofuran

Benzofuran-5-carboxaldehyde

Benzofurancarbaldehyde

Benzo[b]furan-5-carboxaldehyde 96%

5-Formylbenzo[beta]furan, min. 96 %

Benzo[b]furan-5-carboxaldehyde

5-Benzofurancarbaldehyde

Benzofuran-5-carbaldehyde

1-Benzofuran-5-carbaldehyde ,97%

5-Formyl-1-benzofuran

5-Benzofurancarboxaldehyde

5-Formyl-1-benzofuran, 5-Formylbenzo[b]furan, 1-Benzofuran-5-carboxaldehyde

10035-16-2

API intermediates

Furan&Benzofuran