5-Fluoro-2-oxindole

Product Name: 5-Fluoro-2-oxindole
CAS No.: 56341-41-4
Chemical Name: 5-Fluoro-2-oxindole
Synonyms: 5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXYINDOLE;5-FLUOROOXINDOLE;uorooxindoL;Fluorooxindole;5-FLUROOXINDOLE;5-Fluorooxindole98%;5-FLUORO-2-OXINDOLE;5-Fluorooxindole>5-Fluor0-2-oxindole
CBNumber: CB3437333
Molecular Formula: C8H6FNO
Formula Weight: 151.14
MOL File: 56341-41-4.mol

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5-Fluoro-2-oxindole Property

Melting point:: 143-147 °C (lit.)
Boiling point:: 307.2±42.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.99±0.20(Predicted)
form: Powder or Crystalline Powder
color: White to pale brown
InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
InChIKey: DDIIYGHHUMKDGI-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(F)C=C2)CC1=O
CAS DataBase Reference: 56341-41-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 22-24/25-45-36/37/39-27-26
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 586579
Product name: 5-Fluoro-2-oxindole
Purity: 97%
Packaging: 500mg
Price: $133
Updated: 2023/06/20

TCI Chemical

Product number: F0699
Product name: 5-Fluorooxindole
Purity: >98.0%(GC)
Packaging: 1g
Price: $65
Updated: 2024/03/01

TCI Chemical

Product number: F0699
Product name: 5-Fluorooxindole
Purity: >98.0%(GC)
Packaging: 5g
Price: $208
Updated: 2024/03/01

Alfa Aesar

Product number: H32176
Product name: 5-Fluorooxindole, 97%
Packaging: 1g
Price: $82.65
Updated: 2024/03/01

TRC

Product number: F595140
Product name: 5-Fluoro-2-oxindole
Packaging: 500mg
Price: $50
Updated: 2021/12/16

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5-Fluoro-2-oxindole Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Crystalline

Uses

5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.

Application

5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.

Preparation

synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.

Biological Activity

5-Fluoro-2-oxindole has anti-inflammatory, antioxidant, anxiolytic, antidepressant and antinociceptive effects and inhibits neuropathic pain. Treatment with 5-Fluoro-2-oxindole increased the expression of NQO1, HO-1, and MOR in the spinal cord and/or paw and inhibited CFA-induced up-regulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c, and IBA-1. 5-Fluoro-2-oxindole ameliorated the local effects of morphine. Studies have revealed that 5-fluoro-2-oxindole inhibits plasticity, oxidative and inflammatory responses induced by peripheral inflammation and enhances the antinociceptive effects of morphine. Thus, the use of 5-fluoro-2-indole alone and/or in combination with morphine are two remarkable new approaches for the treatment of chronic inflammatory pain.

5-Fluoro-2-oxindole Preparation Products And Raw materials

Raw materials

2,4-Difluoronitrobenzene Sodium hydride Dimethyl malonate Dimethyl sulfoxide Iron Lithium chloride

Preparation Products

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5-Fluoro-2-oxindole Suppliers

Americas 1 Canada 1 China 492 Europe 4 France 3 Germany 7 India 32 Italy 1 Japan 4 Switzerland 2 United Kingdom 19 United States 52 Global 618

CMS Chemicals Limited

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View Lastest Price from 5-Fluoro-2-oxindole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Fluoro-2-oxindole 56341-41-4
Price: US $0.00/G
Min. Order: 100G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-07

Nanjing Fred Technology Co., Ltd

Product: 5-Fluoro-2-oxindole 56341-41-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Hebei Weibang Biotechnology Co., Ltd

Product: 5-Fluoro-2-oxindole 56341-41-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 1KG
Release date: 2024-11-21

56341-41-4, 5-Fluoro-2-oxindoleRelated Search:

Naringin dihydrochalcone Oxindole 4-Fluoroacetophenone 5-Fluoroindole Indole-3-butyric acid Fluorochloridone 4'-(Trifluoromethyl)acetophenone Indole-3-acetic acid cis-Octahydroisoindole Fluridone 1-(2,6-Dichlorophenyl)indolin-2-one Isophorone Dehydroepiandrosterone Indometacin 7-FLUORO-2-OXINDOLE 3-Amino-5-fluoropyridine Sunitinib N-Oxide Sunitinib Impurity B

5-Fluoroindole-2-One

5-Fluoro-1,3-dihydro-indol-2-one

5-FLUORO-2-OXINDOLE

5-FLUORO-2-OXYINDOLE

5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE

5-Fluorooxindole 98%

5-Fluorooxindole98%

5-FLUROOXINDOLE

5-Flouro-1,3-dihydro-indole-2-one

Sunitinib Impurity 49

2H-Indol-2-one,5-fluoro-1,3-dihydro-(9CI)

5-FLUORO-2-OXINDOLE, 98+%

5-FLUORO-2-NITROPHENYLACETATE

5-Fluoro-2-indolinone

2H-Indol-2-one, 5-fluoro-1,3-dihydro-

5-FLUOROOXINDOLE

Fluorooxindole

5-Fluoro-2-oxindole 98%

1H-indol-5-yl hypofluorite

1,3-Dihydro-5-fluoro-2H-indol-2-one, 5-Fluoroindolin-2-one

5-Fluoro-2-oxindole 5-Fluorooxindole

5-Fluoro-2,3-dihydro-2-oxoindole

5‐fluoro‐2,3‐dihydro‐1H‐indol‐2‐one

5-FLUORO-2-OXINDOLE (RETURNED FOR RE-EXP

Sunitinib Impurity 26

5-Fluoro-2-oxindole in stock Factory

5-Fluorooxindole (5-Fluoro-1,3-dihy

5-Fluorooxindole&gt

uorooxindoL

5-Fluor0-2-oxindole

5-Fluoro-2-oxindole ISO 9001：2015 REACH

5-Fluorooxindole (5-Fluoro-1,3-dihydro-2H-indol-2-one)

5-Fluoro-2-oxoindoline

5-flouro-1,3-dihydroindol-2-one,5-flouro-2,3-dihydro-2-oxoindole

56341-41-4

5634-41-4

56341-41-1

5641-41-1

56341-41-1

Heterocyclic Building Blocks

Indoles

Building Blocks

Fluorinated heterocyclic series

Indoles and derivatives

Indole/indoline/oxindole

Indole and Indoline

Heterocycles

Aromatics Compounds

Halides

Pyrroles & Indoles

ketone

Sunitinib

Aromatics

Intermediate of sunitinib malate

Pyrroles & Indoles

Boronic Acid

Heterocyclic Compounds

Building Blocks